The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
KL-6, a Human MUC1 Mucin, Is Chemotactic for Human Fibroblasts
Abstract
KL-6 in serum and bronchoalveolar lavage fluid has been reported to be a sensitive marker indicating the activity of fibrosing lung diseases. The molecule is clustered in MUC1 mucin according to the findings of immunohistochemical and cytometric studies. To elucidate the pathogenic role of KL-6 in fibrosing lung disease, we characterized its biochemical properties and examined whether purified KL-6 is chemotactic for human fibroblasts in vitro using modified Boyden chambers. Biochemical properties of purified KL-6 were similar to those of other MUC1 mucins previously reported. KL-6 promoted the migration of 5 of 5 human lung fibroblasts and 3 of 4 human skin fibroblasts. Checkerboard analysis revealed that KL-6 was chemotactic as well as chemokinetic. Though platelet-derived growth factor, fibroblast growth factor, or fibronectin were also chemotactic for fibroblasts in the experimental system, only fibronectin augmented KL-6-induced chemotaxis. These observations indicate that KL-6 is one of the chemotactic factors for most fibroblasts and that the increased KL-6 in the epithelial lining fluid in small airways may cause the intra-alveolar fibrosis in fibrosing lung diseases.
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Bitterman, P. B., Wewers, M. D., Rennard, S. I., Adelberg, S., & Crystal, R. G. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112364 · Cited by 232
Cited by
Lung Epithelium–specific Proteins: Characteristics and Potential Applications as Markers
HERMANS, C., & BERNARD, A. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.2.9806064 · Cited by 428
OHNISHI, H., YOKOYAMA, A., KONDO, K., HAMADA, H., ABE, M., NISHIMURA, K., HIWADA, K., & KOHNO, N. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.3.2107134 · Cited by 398
Self-citationBlood Biomarkers in Idiopathic Pulmonary Fibrosis
Guiot, J., Moermans, C., Henket, M., Corhay, J.-L., & Louis, R. (2017) · Lung · doi:10.1007/s00408-017-9993-5 · Cited by 147
MUC1 (CD227): a multi-tasked molecule
Apostolopoulos, V., Stojanovska, L., & Gargosky, S. E. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2014-z · Cited by 138
Inoue, Y., Kaner, R. J., Guiot, J., Maher, T. M., Tomassetti, S., Moiseev, S., Kuwana, M., & Brown, K. K. (2020) · Chest · doi:10.1016/j.chest.2020.03.037 · Cited by 133
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Metadata
- Authors
- Hirasawa, Y., Kohno, N., Yokoyama, A., Inoue, Y., Abe, M., & Hiwada, K.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-10-01
- Volume
- 17
- Issue
- 4
- Pages
- 501-507
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2172082813
- Cited by
- 179
- References
- 1
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hirasawa, Y., Kohno, N., Yokoyama, A., Inoue, Y., Abe, M., & Hiwada, K. (1997). KL-6, a Human MUC1 Mucin, Is Chemotactic for Human Fibroblasts. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/ajrcmb.17.4.2253
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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