Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators
Open accessAbstract
Tissue fibrosis results, in part, from an interaction between growth regulatory molecules released by mononuclear phagocytes and fibroblasts. In the chronic interstitial lung disorders, alveolar macrophages, the mononuclear phagocytes of the lung, are known to spontaneously release two growth factors for fibroblasts, fibronectin and alveolar macrophage-derived growth factor (AMDGF) that together stimulate nonreplicating lung fibroblasts to divide. In addition to these two primary growth promoting signals, alveolar macrophages are able to release other mediators that may have a potential role in modulating lung fibroblast replication in response to these primary signals, including interferon gamma (IFN gamma), prostaglandin E2 (PGE2), and interleukin 1 (IL-1). To evaluate this possibility, we examined the effect of each of these other mediators on lung fibroblast replication in response to fibronectin and AMDGF in serum-free, defined medium. IFN gamma had no effect on fibroblast replication. In contrast, PGE2 resulted in a dose-dependent inhibition of fibroblast replication in response to fibronectin and AMDGF with 50% of the maximum inhibition observed at a PGE2 concentration of less than 10 ng/ml. IL-1, while not active as a primary growth promoting signal, at concentrations of 4-10 U/ml, augmented fibroblast replication in response to fibronectin and AMDGF by 10 to 15%. Temporally, the growth augmenting effect of IL-1 occurred early in the G1 phase of the cell cycle. These data indicate that lung fibroblast replication in response to two of the primary growth promoting signals spontaneously released by alveolar macrophages in the interstitial lung disorders, while uninfluenced by IFN gamma, can be inhibited by PGE2 and modestly augmented by IL-1. Understanding the relevant fibroblast growth modulatory signals within the alveolar microenvironment in the chronic interstitial disorders may lead to rational therapeutic strategies designed to interrupt the fibrotic process.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Alveolar macrophages obtained from patients with IPF stimulate fibroblast accumulation via a paracrine mechanism involving production of soluble mediators typically associated with alternative activation.
“alveolar macrophages obtained from patients with IPF were shown to stimulate fibroblast accumulation via a paracrine mechanism involving the production of soluble mediators typically associated with alternative activation (18)”
From The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis (2018) · cites this paper as [18]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Binding of soluble form of fibroblast surface protein, fibronectin, to collagen
Engvall, E., & Ruoslahti, E. (1977) · International Journal of Cancer · doi:10.1002/ijc.2910200102 · Cited by 1,433 · see citing works
Interleukin 1, a potential regulator of fibroblast proliferation.
Schmidt, J. A., Mizel, S. B., Cohen, D. A., & Green, I. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.128.5.2177 · Cited by 830 · see citing works
Interstitial Lung Diseases of Unknown Cause
Crystal, R. G., Bitterman, P. B., Rennard, S. I., Hance, A. J., & Keogh, B. A. (1984) · New England Journal of Medicine · doi:10.1056/nejm198401193100304 · Cited by 701 · see citing works
Self-citationEnzyme-linked immunoassay (ELISA) for connective tissue components
Rennard, S. I., Berg, R. A., Martin, G. R., Foidart, J., & Robey, P. G. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90300-0 · Cited by 605 · see citing works
Self-citationA macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro.
Leibovich, S. J., & Ross, R. (1976) · PubMed · Cited by 580 · see citing works
Macrophages synthesise and release prostaglandins in response to inflammatory stimuli
Humes, J. L., Bonney, R. J., Pelus, L. M., Dahlgren, M. E., Sadowski, S. J., Kuehl, F. A., & DAVIES, P. (1977) · Nature · doi:10.1038/269149a0 · Cited by 566 · see citing works
An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis
Pledger, W. J., Stiles, C. D., Antoniades, H. N., & Scher, C. D. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.6.2839 · Cited by 458 · see citing works
Robinson, B. W. S., McLemore, T. L., & Crystal, R. G. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111852 · Cited by 454 · see citing works
Self-citationRennard, S. I., Hunninghake, G. W., Bitterman, P. B., & Crystal, R. G. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.7147 · Cited by 340 · see citing works
Self-citationScadding, J. G., & Hinson, K. F. W. (1967) · Thorax · doi:10.1136/thx.22.4.291 · Cited by 305 · see citing works
Role of fibronectin as a growth factor for fibroblasts.
Bitterman, P. B., Rennard, S. I., Adelberg, S. A., & Crystal, R. G. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.6.1925 · Cited by 303 · see citing works
Self-citationHuman Alveolar Macrophage Growth Factor for Fibroblasts
Bitterman, P. B., Rennard, S. I., Hunninghake, G. W., & Crystal, R. G. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110677 · Cited by 297 · see citing works
Self-citationKorn, J. H., Halushka, P. V., & LeRoy, E. C. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109698 · Cited by 282 · see citing works
Rinderknecht, E., O'Connor, B. H., & Rodriguez, H. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39797-1 · Cited by 271 · see citing works
VOGEL, A. M., Raines, E. W., Kariya, B., Rivest, M. J., & Ross, R. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.6.2810 · Cited by 252 · see citing works
Schmidt, J. A., Oliver, C. N., Lepe-Zuniga, J. L., Green, I., & Gery, I. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111350 · Cited by 252 · see citing works
Role of attachment factors and attractants in fibroblast chemotaxis.
Gauss‐Müller, V., Hk, K., Gr, M., & Schiffmann, E. (1980) · PubMed · Cited by 220 · see citing works
Rosenwasser, L. J., & Dinarello, C. A. (1981) · Cellular Immunology · doi:10.1016/0008-8749(81)90034-4 · Cited by 219 · see citing works
Bitterman, P. B., Adelberg, S. A., & Crystal, R. G. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111140 · Cited by 217 · see citing works
Self-citationPathologic changes in the lungs of oxygen-adapted rats: a morphometric analysis.
Jd, C., Peters-Golden, M. L., Marsh-Salin, J., & Js, S. (1978) · PubMed · Cited by 216 · see citing works
Blalock, J. E., Georgiades, J. A., Langford, M. P., & Johnson, H. M. (1980) · Cellular Immunology · doi:10.1016/0008-8749(80)90041-6 · Cited by 214 · see citing works
Release of interleukin-1 by alveolar macrophages of patients with active pulmonary sarcoidosis.
Hunninghake, G. W. (1984) · PubMed · Cited by 212 · see citing works
Bitterman, P. B., Saltzman, L. E., Adelberg, S. A., Ferrans, V. J., & Crystal, R. G. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111443 · Cited by 209 · see citing works
Self-citationProstaglandin and thromboxane production by human and guinea-pig macrophages and leucocytes
Morley, J. E., Bray, M. A., Jones, R. W., Nugteren, D. H., & van Dorp, D. A. (1979) · Prostaglandins · doi:10.1016/s0090-6980(79)80044-1 · Cited by 192 · see citing works
STRUCTURE AND FUNCTION IN SARCOIDOSIS*
Carrington, C. B., Gaensler, E. A., Mikus, J. P., Schachter, A. W., Burke, G. W., & Goff, A. M. (1976) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1976.tb47038.x · Cited by 190 · see citing works
Glenn, K. C., & Ross, R. (1981) · Cell · doi:10.1016/0092-8674(81)90168-9 · Cited by 189 · see citing works
ENGINEER, D. M., Niederhauser, U., Piper, P. J., & Sirois, P. (1978) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1978.tb07006.x · Cited by 188 · see citing works
Lung injury induced by butylated hydroxytoluene: cytodynamic and biochemical studies in mice.
Adamson, I. Y., Bowden, D. H., Côté, M. G., & Witschi, H. R. (1977) · PubMed · Cited by 184 · see citing works
Fibroblast heterogeneity and prostaglandin regulation of subpopulations
Ko, S. D., Page, R. C., & Narayanan, A. S. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3429 · Cited by 182 · see citing works
Wewers, M. D., Rennard, S. I., Hance, A. J., Bitterman, P. B., & Crystal, R. G. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111647 · Cited by 164 · see citing works
Self-citationHance, A. J., Douches, S. D., Winchester, R. J., Ferrans, V. J., & Crystal, R. G. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.1.284 · Cited by 155 · see citing works
Self-citationRennard, S. I., & Crystal, R. G. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110421 · Cited by 143 · see citing works
Self-citationDifferences in domain structures between plasma and cellular fibronectins.
Hayashi, M., & Yamada, K. M. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68590-x · Cited by 143 · see citing works
Potentiation of Butylated Hydroxytoluene-induced Acute Lung Damage by Oxygen
Haschek, W. M., Reiser, K. M., Klein–Szanto, A. J., Kehrer, J. P., Smith, L. H., Last, J. A., & Witschi, H. R. (1983) · American Review of Respiratory Disease · doi:10.1164/arrd.1983.127.1.28 · Cited by 112 · see citing works
Johnson, H. M., & Farrar, W. L. (1983) · Cellular Immunology · doi:10.1016/0008-8749(83)90314-3 · Cited by 100 · see citing works
Clark, J. G., Kostal, K. M., & Marino, B. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34302-3 · Cited by 92 · see citing works
Increased proliferation of human synovial fibroblasts treated with recombinant immune interferon.
Brinckerhoff, C., & Guyre, P. M. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.5.3142 · Cited by 80 · see citing works
Pulmonary injury in rats following continuous exposure to 60% O2 for 7 days
Hayatdavoudi, G., O’Neil, J. J., Barry, B. E., Freeman, B. A., & Crapo, J. D. (1981) · Journal of Applied Physiology · doi:10.1152/jappl.1981.51.5.1220 · Cited by 70 · see citing works
Macrophage-Derived Growth Factor for Fibroblasts and Interleukin-1 Are Distinct Entities
Estes, J. E., Pledger, W. J., & Gillespie, G. Y. (1984) · Journal of Leukocyte Biology · doi:10.1002/jlb.35.1.115 · Cited by 69 · see citing works
Purification and partial biochemical characterization of normal human interleukin 1.
Schmidt, J. A. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.160.3.772 · Cited by 68 · see citing works
The Comparative Biology of Immune and Classical Interferons
Epstein, L. B. (1979) · Elsevier eBooks · doi:10.1016/b978-0-12-178250-4.50022-2 · Cited by 63 · see citing works
Human monocyte stimulation of fibroblast growth by a soluble mediator(s).
Delustro, F. A., Sherer, G. K., & LeRoy, E. C. (1980) · PubMed · Cited by 63 · see citing works
Evans, M. J., & Bils, R. F. (1969) · American Review of Respiratory Disease · doi:10.1164/arrd.1969.100.3.372 · Cited by 62 · see citing works
Self regulation of growth by human diploid fibroblasts via prostaglandin production
Taylor, L., & POLGAR, P. R. (1977) · FEBS Letters · doi:10.1016/0014-5793(77)80352-9 · Cited by 60 · see citing works
Interstitial associations of cells lining air spaces in human pulmonary fibrosis
Brody, A. R., & Craighead, J. E. (1976) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00429715 · Cited by 43 · see citing works
Lacronique, J., Rennard, S. I., Bitterman, P. B., Ozaki, T., & Crystal, R. G. (1984) · PubMed · doi:10.1164/arrd.1984.130.3.450 · Cited by 39 · see citing works
Self-citationSpencer, H. (1967) · Annual Review of Medicine · doi:10.1146/annurev.me.18.020167.002231 · Cited by 38 · see citing works
Pulmonary injury and repair. Organ culture studies of murine lung after oxygen.
Yi, A., & Bowden, D. H. (1976) · PubMed · Cited by 31 · see citing works
Inhibition of lung fibroblast growth by human lung mononuclear cells.
Elias, J. A., Zurier, R. B., Rossman, M. D., Berube, M. L., & Daniele, R. P. (1984) · PubMed · doi:10.1164/arrd.1984.130.5.810 · Cited by 21 · see citing works
Kunkel, S. L., & Duque, R. E. (1983) · Prostaglandins · doi:10.1016/0090-6980(83)90152-1 · Cited by 12 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Ko, S. D., R. C. Page, and A. S. Narayaran. 1977. Fibroblast heterogeneity and prostaglandin regulation ofsubpopulations. Proc. Natl. Acad. Sci. USA. 74:3429-3432.
- Rennard, S., P. Bitterman, T. Ozaki, and R. G. Crystal. 1984. Colchicine blocks the release of mediators of fibrosis by human alveolar macrophages. Clin. Res. 32(2):246a (Abstr.)
Cited by
Sorted by citations
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615 · see citing works
Macrophages and Polymorphonuclear Neutrophils in Lung Defense and Injury
Sibille, Y., & Reynolds, H. Y. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.2.471 · Cited by 1,083 · see citing works
Pathogenic Mechanisms Underlying Idiopathic Pulmonary Fibrosis
Moss, B. J., Ryter, S. W., & Rosas, I. O. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042320-030240 · Cited by 839 · see citing works
The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation
Munro, J. M., & Cotran, R. S. (1989) · Humana Press eBooks · doi:10.1007/978-1-4612-4502-5_10 · Cited by 698 · see citing works
Kumar, R. K. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/142.5.1234 · Cited by 559 · see citing works
Libby, P., Warner, S. J., & Friedman, G. B. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113346 · Cited by 532 · see citing works
Targeted Injury of Type II Alveolar Epithelial Cells Induces Pulmonary Fibrosis
Sisson, T. H., Mendez, M. P., Choi, K., Subbotina, N., Courey, A. J., Cunningham, A. K., Dave, A., Engelhardt, J. F., Liu, X., White, E. S., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200810-1615oc · Cited by 474 · see citing works
Ono, K., Matsumori, A., Shioi, T., Furukawa, Y., & Sasayama, S. (1998) · Circulation · doi:10.1161/01.cir.98.2.149 · Cited by 459 · see citing works
Martinet, Y., Rom, W. N., Grotendorst, G. R., Martin, G. R., & Crystal, R. G. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707233170404 · Cited by 414 · see citing works
Self-citationWilborn, J., Crofford, L. J., Burdick, M. D., Kunkel, S. L., Strieter, R. M., & Peters-Golden, M. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117866 · Cited by 390 · see citing works
The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis
Desai, O., Winkler, J., Minasyan, M., & Herzog, E. L. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00043 · Cited by 314 · see citing works
Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling
Holgate, S. T., Peters-Golden, M. L., Panettieri, R. A., & Henderson, W. R. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.25 · Cited by 319 · see citing works
Kolodsick, J. E., Peters-Golden, M., Larios, J., Toews, G. B., Thannickal, V. J., & Moore, B. B. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2002-0243oc · Cited by 294 · see citing works
(1990) · European Respiratory Journal · doi:10.1183/09031936.93.03080937 · Cited by 287 · see citing works
Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis
Sakai, N., & Tager, A. M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.03.001 · Cited by 286 · see citing works
Alveolar macrophages release an insulin-like growth factor I-type molecule.
Rom, W. N., Basset, P., Fells, G. A., Nukiwa, T., Trapnell, B. C., & Crysal, R. G. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113781 · Cited by 249 · see citing works
From Seminars in Respiratory and Critical Care Medicine
Spurzem, J. R., & Rennard, S. I. (2011) · Cited by 215 · see citing works
Self-citationNovel therapeutic approaches for pulmonary fibrosis
Datta, A., Scotton, C. J., & Chambers, R. C. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01247.x · Cited by 203 · see citing works
Protection from Pulmonary Fibrosis in Leukotriene-Deficient Mice
Peters-Golden, M. L., Bailie, M. B., Marshall, T. M., Wilke, C. A., Phan, S. H., Toews, G. B., & Moore, B. B. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.2.2104050 · Cited by 187 · see citing works
Park, G. Y., & Christman, J. W. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00513.2005 · Cited by 183 · see citing works
Crystal, R., Bitterman, P., Mossman, B., Schwarz, M., Sheppard, D., Almasy, L., Chapman, H., Friedman, S., King, T., Leinwand, L., et al. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2201069 · Cited by 185 · see citing works
Self-citationEnhanced Generation of Free Radicals from Phagocytes Induced by Mineral Dusts
Vallyathan, V., Mega, J. F., Shi, X., & Dalal, N. S. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/6.4.404 · Cited by 180 · see citing works
KL-6, a Human MUC1 Mucin, Is Chemotactic for Human Fibroblasts
Hirasawa, Y., Kohno, N., Yokoyama, A., Inoue, Y., Abe, M., & Hiwada, K. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.17.4.2253 · Cited by 179 · see citing works
Wilborn, J., Bailie, M. D., Coffey, M., Burdick, M., Strieter, R. M., & Peters-Golden, M. L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118612 · Cited by 176 · see citing works
Berman, B., & Duncan, M. R. (1989) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(89)70239-5 · Cited by 173 · see citing works
Duncan, M. R., & Berman, B. (1989) · Journal of Investigative Dermatology · doi:10.1016/0022-202x(89)90185-1 · Cited by 171 · see citing works
Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro
Saito, A., Okazaki, H., Sugawara, I., Yamamoto, K., & Takizawa, H. (2003) · International Archives of Allergy and Immunology · doi:10.1159/000073718 · Cited by 167 · see citing works
GM-CSF Regulates Bleomycin-Induced Pulmonary Fibrosis Via a Prostaglandin-Dependent Mechanism
Moore, B. B., Coffey, M. J., Christensen, P., Sitterding, S., Ngan, R., Wilke, C. A., McDonald, R., Phare, S. M., Peters-Golden, M., Paine, R., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.4032 · Cited by 158 · see citing works
Lama, V. N., Moore, B. B., Christensen, P. J., Toews, G. B., & Peters-Golden, M. L. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.4857 · Cited by 155 · see citing works
Prevention and Management of Hypertrophic Scars and Keloids After Burns in Children
Berman, B., Viera, M. H., Amini, S., Huo, R., & Jones, I. S. (2008) · Journal of Craniofacial Surgery · doi:10.1097/scs.0b013e318175f3a7 · Cited by 155 · see citing works
Prostaglandin E <sub>2</sub> induces fibroblast apoptosis by modulating multiple survival pathways
Huang, S. K., White, E. S., Wettlaufer, S. H., Grifka, H., Hogaboam, C. M., Thannickal, V. J., Horowitz, J. C., & Peters-Golden, M. (2009) · The FASEB Journal · doi:10.1096/fj.08-128801 · Cited by 147 · see citing works
Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis
Horowitz, J. C., & Thannickal, V. J. (2006) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-2006-957332 · Cited by 146 · see citing works
Huang, S. K., Fisher, A. S., Scruggs, A. M., White, E. S., Hogaboam, C. M., Richardson, B. C., & Peters-Golden, M. L. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100446 · Cited by 141 · see citing works
Bleomycin-Induced E Prostanoid Receptor Changes Alter Fibroblast Responses to Prostaglandin E2
Moore, B. B., Ballinger, M. N., White, E. S., Green, M. E., Herrygers, A. B., Wilke, C. A., Toews, G. B., & Peters-Golden, M. L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5644 · Cited by 135 · see citing works
Borok, Z., Gillissen, A., Buhl, R., Hoyt, R. F., Hubbard, R. C., Ozaki, T., Rennard, S. I., & Crystal, R. G. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/144.5.1080 · Cited by 131 · see citing works
Self-citationProstaglandin E2 and the Pathogenesis of Pulmonary Fibrosis
Bozyk, P. D., & Moore, B. B. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0025rt · Cited by 131 · see citing works
White, E. S., Atrasz, R. G., Dickie, E. G., Aronoff, D. M., Stambolic, V., Mak, T. W., Moore, B. B., & Peters-Golden, M. L. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0126oc · Cited by 131 · see citing works
COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis
Lovgren, A. K., Jania, L. A., Hartney, J. M., Parsons, K. K., Audoly, L., FitzGerald, G. A., Tilley, S. L., & Koller, B. H. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00492.2005 · Cited by 127 · see citing works
Hodges, R. J., Jenkins, G. R., Wheeler-Jones, C. P. D., Copeman, D. M., Bottoms, S. E., Bellingan, G. J., Nanthakumar, C. B., Laurent, G. J., Hart, S. L., Foster, M. L., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63423-2 · Cited by 124 · see citing works
Olman, M. A., White, K. E., Ware, L. B., Simmons, W. L., Benveniste, E. N., Zhu, S., Pugin, J., & Matthay, M. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2668 · Cited by 124 · see citing works
Berman, B., & Duncan, M. R. (1989) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12712140 · Cited by 117 · see citing works
Cigarette Smoking Decreases Global MicroRNA Expression in Human Alveolar Macrophages
Graff, J. W., Powers, L. S., Dickson, A. M., Kim, J.-K., Reisetter, A. C., Hassan, I. H., Kremens, K., Gross, T. J., Wilson, M. E., & Monick, M. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044066 · Cited by 114 · see citing works
SARS-CoV Regulates Immune Function-Related Gene Expression in Human Monocytic Cells
Hu, W., Yen, Y.-T., Singh, S., Kao, C., & Wu‐Hsieh, B. A. (2012) · Viral Immunology · doi:10.1089/vim.2011.0099 · Cited by 112 · see citing works
Prostaglandin Receptor Signaling in Disease
Matsuoka, T., & Narumiya, S. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.182 · Cited by 112 · see citing works
Moore, B. B., Peters-Golden, M. L., Christensen, P. J., Lama, V. N., Kuziel, W. A., Paine, R., & Toews, G. B. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00168.2002 · Cited by 112 · see citing works
Acute lung injury. Pathogenesis of intraalveolar fibrosis.
Snyder, L. S., Hertz, M. I., Peterson, M. S., Harmon, K. R., Marinelli, W. A., Henke, C. A., Greenheck, J. R., Chen, B., & Bitterman, P. B. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115351 · Cited by 100 · see citing works
Self-citationBorm, P. J. A., Palmen, N., Engelen, J. J. M., & Buurman, W. A. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/138.6.1589 · Cited by 97 · see citing works
Pulmonary response to inhaled silica or titanium dioxide
Driscoll, K. E., Lindenschmidt, R. C., Maurer, J. K., Perkins, L., Perkins, M., & Higgins, J. M. (1991) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(91)90024-9 · Cited by 95 · see citing works
Driscoll, K. E., & Maurer, J. K. (1991) · Toxicologic Pathology · doi:10.1177/0192623391019004-108 · Cited by 90 · see citing works
Prostaglandin E2 Affects Proliferation and Collagen Synthesis by Human Patellar Tendon Fibroblasts
Çilli, F., Khan, M. H., Fu, F. H., & Wang, J. H. (2004) · Clinical Journal of Sport Medicine · doi:10.1097/00042752-200407000-00006 · Cited by 92 · see citing works
Duncan, M. R., & Berman, B. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112956 · Cited by 92 · see citing works
Duncan, M. R., & Berman, B. (1989) · Archives of Dermatological Research · doi:10.1007/bf00424266 · Cited by 88 · see citing works
Martinet, Y., Yamauchi, K., & Crystal, R. G. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/138.3.659 · Cited by 88 · see citing works
Self-citationRegulation of lung cell proliferation by polypeptide growth factors
King, R., Jones, M., & Minoo, P. (1989) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1989.257.2.l23 · Cited by 87 · see citing works
Prostaglandin E2protects murine lungs from bleomycin-induced pulmonary fibrosis and lung dysfunction
Dackor, R. T., Cheng, J., Voltz, J. W., Card, J. W., Ferguson, C. D., Garrett, R. C., Bradbury, J. A., DeGraff, L. M., Lih, F. B., Tomer, K. B., et al. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00176.2011 · Cited by 85 · see citing works
Extracellular Glutathione Suppresses Human Lung Fibroblast Proliferation
Cantin, A. M., Larivée, P., & Begin, R. O. (1990) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/3.1.79 · Cited by 83 · see citing works
Deficiencies in collagen phagocytosis by human fibroblasts in vitro: A mechanism for fibrosis?
McCulloch, C. A. G., & Knowles, G. C. (1993) · Journal of Cellular Physiology · doi:10.1002/jcp.1041550305 · Cited by 83 · see citing works
Driscoll, K. E. (1990) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(90)90109-8 · Cited by 83 · see citing works
Mitochondrial Cu,Zn-Superoxide Dismutase Mediates Pulmonary Fibrosis by Augmenting H2O2 Generation
He, C., Murthy, S., McCormick, M. L., Spitz, D. R., Ryan, A. J., & Carter, A. B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.187377 · Cited by 82 · see citing works
Ashrafizadeh, M., Zarrabi, A., Hushmandi, K., Zarrin, V., Moghadam, E. R., Hashemi, F., Makvandi, P., Samarghandian, S., Khan, H. Z., Hashemi, F., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.585413 · Cited by 79 · see citing works
Innovative therapies in the treatment of keloids and hypertrophic scars.
Viera, M. H., Amini, S., Valins, W., & Berman, B. (2010) · PubMed Central · Cited by 78 · see citing works
Eicosanoids: mediators and therapeutic targets in fibrotic lung disease
Charbeneau, R. P., & Peters-Golden, M. L. (2005) · Clinical Science · doi:10.1042/cs20050012 · Cited by 78 · see citing works
Variable Prostaglandin E2 Resistance in Fibroblasts from Patients with Usual Interstitial Pneumonia
Huang, S. K., Wettlaufer, S. H., Hogaboam, C. M., Flaherty, K. R., Martínez, F. J., Myers, J. L., Colby, T. V., Travis, W. D., Toews, G. B., & Peters-Golden, M. L. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200706-963oc · Cited by 76 · see citing works
Zerbe, O., & Gressner, A. (1988) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(88)90023-8 · Cited by 75 · see citing works
Cysteinyl Leukotrienes Are Autocrine and Paracrine Regulators of Fibrocyte Function
Vannella, K. M., McMillan, T. R., Charbeneau, R. P., Wilke, C. A., Thomas, P. E., Toews, G. B., Peters-Golden, M. L., & Moore, B. B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7883 · Cited by 74 · see citing works
Gerdes, J. S., Harris, M. C., & Polin, R. A. (1988) · The Journal of Pediatrics · doi:10.1016/s0022-3476(88)80390-1 · Cited by 74 · see citing works
Vallyathan, V., Kang, J.-H., Dyke, K. V., Dalai, N. S., & Castranova, V. (1991) · Journal of Toxicology and Environmental Health · doi:10.1080/15287399109531529 · Cited by 73 · see citing works
Heterogeneity in hormone responses and patterns of collagen synthesis in cloned dermal fibroblasts.
Goldring, S. R., Stephenson, M. L., Downie, E., Krane, S. M., & Korn, J. H. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114506 · Cited by 72 · see citing works
Characterization of the Effect of Interleukin-10 on Silica-Induced Lung Fibrosis in Mice
Barbarin, V., Arras, M., Misson, P., Delos, M., McGarry, B. M., Phan, S. H., Lison, D., & Huaux, F. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0299oc · Cited by 72 · see citing works
Watts, C. L., Fanaroff, A. A., & Bruce, M. C. (1992) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)82492-8 · Cited by 71 · see citing works
PDE4 inhibitors roflumilast and rolipram augment PGE 2 inhibition of TGF-β1-stimulated fibroblasts
Togo, S., Liu, X., Wang, X., Sugiura, H., Kamio, K., Kawasaki, S., Kobayashi, T., Ertl, R. F., Ahn, Y., Holz, O., et al. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00508.2007 · Cited by 70 · see citing works
Self-citationResponsiveness of Stromal Fibroblasts to IFN-γ Blocks Tumor Growth via Angiostasis
Yu, L., Yang, W. C., Qin, C., Zhang, L., Deng, J., Liu, S., & Qin, Z. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901073 · Cited by 69 · see citing works
Havemose‐Poulsen, A., & Holmstrup, P. (1997) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411970080020801 · Cited by 67 · see citing works
Thornton, S. C., Por, S. B., Walsh, B. J., Penny, R., & Breit, S. N. (1990) · Journal of Leukocyte Biology · doi:10.1002/jlb.47.4.312 · Cited by 68 · see citing works
Jorens, P. G., van Overveld, F. J., Vermeire, P. A., Bult, H., & Herman, A. G. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)94811-9 · Cited by 62 · see citing works
White, K. E., Ding, Q., Moore, B. B., Peters-Golden, M. L., Ware, L. B., Matthay, M. A., & Olman, M. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.637 · Cited by 61 · see citing works
Sun, H., Zhu, Y., Pan, H., Chen, X., Balestrini, J. L., Lam, T. T., Kanyo, J. E., Eichmann, A., Gulati, M., Fares, W. H., et al. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39575 · Cited by 61 · see citing works
Protease‐activated receptors and prostaglandins in inflammatory lung disease
Peters, T., & Henry, P. J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00449.x · Cited by 58 · see citing works
From granuloma to fibrosis in interstitial lung diseases: molecular and cellular interactions
Mornex, J., Leroux, C., Greenland, T., & Ecochard, D. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07040779 · Cited by 55 · see citing works
Rehan, M., Kurundkar, D., Kurundkar, A., Logsdon, N. J., Smith, S. R., Chanda, D., Bernard, K. F., Sanders, Y. Y., Deshane, J. S., Dsouza, K. G., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00027-5 · Cited by 56 · see citing works
Airway remodeling in murine asthma correlates with a defect in PGE2synthesis by lung fibroblasts
Stumm, C. L., Wettlaufer, S. H., Jancar, S., & Peters-Golden, M. L. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00158.2011 · Cited by 52 · see citing works
Rennard, S. I. (1996) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(96)70076-3 · Cited by 52 · see citing works
Self-citationIncreased TNF-α Secretion by Alveolar Macrophages from Patients with Rheumatoid Arthritis
Gosset, P., Perez, T., Lassalle, P., Duquesnoy, B., Farre, J. M., Tonnel, A., & Capron, A. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/143.3.593 · Cited by 52 · see citing works
Il‐1β and prostaglandins regulate integrin mRNA expression
Milam, S. B., Magnuson, V. L., Steffensen, B., Chen, D., & Klebe, R. J. (1991) · Journal of Cellular Physiology · doi:10.1002/jcp.1041490202 · Cited by 51 · see citing works
Prostaglandin E2 As an Inhibitory Modulator of Fibrogenesis in Human Lung Allografts
Walker, N., Badri, L. N., Wadhwa, A., Wettlaufer, S. H., Peters-Golden, M. L., & Lama, V. N. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201105-0834oc · Cited by 50 · see citing works
Fibroblast biology. Signals targeting the synovial fibroblast in arthritis.
Konttinen, Y. T., Li, T.-F., Hukkanen, M., Ma, J., Xu, J., & Virtanen, I. (2000) · Arthritis Research · doi:10.1186/ar111 · Cited by 50 · see citing works
Horowitz, J. C., & Thannickal, V. J. (2006) · Treatments in Respiratory Medicine · doi:10.2165/00151829-200605050-00004 · Cited by 48 · see citing works
The Pulmonary Response to Sublethal Thoracic Irradiation in the Rat
Ward, H. E., Kemsley, L., Davies, L., Holeček, M., & Berend, N. (1993) · Radiation Research · doi:10.2307/3578634 · Cited by 49 · see citing works
Thornton, S. C., Por, S. B., PENNY, R., RICHTER, M., Shelley, L., & Breit, S. N. (1991) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1991.tb05777.x · Cited by 49 · see citing works
Fibroblast Proliferation Induced by Silica-exposed Human Alveolar Macrophages
Brown, G. P., Monick, M. M., & Hunninghake, G. W. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/138.1.85 · Cited by 49 · see citing works
Role of insulin-like growth factor-I in allergen-induced airway inflammation and remodeling
Yamashita, N., Tashimo, H., Ishida, H., Matsuo, Y., Arai, H., Nagase, H., Adachi, T., & Ohta, K. (2005) · Cellular Immunology · doi:10.1016/j.cellimm.2005.07.006 · Cited by 48 · see citing works
Fukuoka, T., Kitami, Y., Okura, T., & Hiwada, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25576 · Cited by 48 · see citing works
Asano, K., Nakamura, H., Lilly, C. M., Klagsbrun, M., & Drazen, J. M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119233 · Cited by 47 · see citing works
Berman, B., Wietzerbin, J., Sanceau, J., Merlin, G., & Duncan, M. R. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12499916 · Cited by 47 · see citing works
Hepatic mechanisms for clearance and detoxification of bacterial endotoxins
Fox, E. S., Thomas, P., & Broitman, S. A. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90020-l · Cited by 47 · see citing works
Heard, B. E., Dewar, A. L., & CORRIN, B. (1992) · The Journal of Pathology · doi:10.1002/path.1711660314 · Cited by 47 · see citing works
Elias, J. A., Gustilo, K., & Freundlich, B. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/138.6.1595 · Cited by 47 · see citing works
Regulation of macrophage activation by lactylation in lung disease
Wei, Y., Guo, H., Chen, S., & Tang, X. X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1427739 · Cited by 44 · see citing works
Evolving Perspectives on Innate Immune Mechanisms of IPF
Ishikawa, G., Liu, A., & Herzog, E. L. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.676569 · Cited by 43 · see citing works
Corticosteroids in idiopathic pulmonary fibrosis
Lynch, J. P., White, E. S., & Flaherty, K. (2001) · Current Opinion in Pulmonary Medicine · doi:10.1097/00063198-200109000-00009 · Cited by 43 · see citing works
- Authors
- Bitterman, P. B., Wewers, M. D., Rennard, S. I., Adelberg, S., & Crystal, R. G.
- Affiliations
- National Institutes of Health (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1986-03-01
- Volume
- 77
- Issue
- 3
- Pages
- 700-708
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC423453
- OpenAlex
- W1971418747
- Cited by
- 232
- References
- 50
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 6
- FWCI
- 19.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- alveolar macrophages, lung fibroblast proliferation, fibrosis, fibronectin, prostaglandin E2, interleukin-1, interferon-gamma, G1 phase
- MeSH terms
- Cell Cycle, Culture Media, Fibroblasts, Fibronectins, Growth Substances, Humans, Interferon-gamma, Interleukin-1, Lung, Macrophages, Peptides, Prostaglandins E, Pulmonary Fibrosis, Time Factors, Dinoprostone, Intercellular Signaling Peptides and Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
