The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Surfactant Protein-A-Deficient Mice Are Susceptible to Pseudomonas aeruginosa Infection
Abstract
To determine the role of surfactant protein-A (SP-A) in host defense, the murine SP-A locus was targeted by homologous recombination to produce mice lacking SP-A. SP-A-/- and wild-type mice were infected with mucoid Pseudomonas aeruginosa by intratracheal instillation. Pulmonary bacterial loads were greater in SP-A-/- than in wild-type mice, with increased numbers of mucoid P. aeruginosa in lung homogenates at 6 and 24 h after infection. Pulmonary infiltration with polymorphonuclear leukocytes (PMN) was similar in both groups; however, an earlier influx of PMN into the lung occurred in the SP-A-/- mice. The number of bacteria phagocytosed by alveolar macrophages was decreased in the SP-A-/- mice at 1 h after infection. Superoxide-radical generation by PMN was similar for the SP-A-/- and wild-type mice, but nitrite levels were increased in SP-A-/- mice. Concentrations of tumor necrosis factor-alpha, interleukin-6, and macrophage inflammatory protein-2 (proinflammatory cytokines) were greater in bronchoalveolar lavage fluid at 2 h after infection in SP-A-/- mice. SP-A plays an important role in the pathogenesis of mucoid P. aeruginosa infection in the lung in vivo by enhancing macrophage phagocytosis and clearance of bacteria, and by modifying the inflammatory response.
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Cites
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Self-citationFang, F. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119473 · Cited by 1,149
Incidence, Risk, and Prognosis Factors of Nosocomial Pneumonia in Mechanically Ventilated Patients
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Altered surfactant function and structure in SP-A gene targeted mice.
Korfhagen, T. R., Bruno, M. D., Ross, G. F., Huelsman, K. M., Ikegami, M., Jobe, A. H., Wert, S. E., Stripp, B. R., Morris, R. E., Glasser, S. W., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9594 · Cited by 405
Self-citationPulmonary Surfactant Protein A Enhances the Host-defense Mechanism of Rat Alveolar Macrophages
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Cited by
Collectins and Ficolins: Humoral Lectins of the Innate Immune Defense
Holmskov, U., Thiel, S., & Jensenius, J. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140954 · Cited by 762
Surfactant Proteins A and D and Pulmonary Host Defense
Crouch, E., & Wright, J. R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.521 · Cited by 632
Surfactant proteins SP-A and SP-D: structure, function and receptors
Kishore, U., Greenhough, T. J., Waters, P., Shrive, A. K., Ghai, R., Kamran, M. F., Bernal, A. L., Reid, K. B. M., Madan, T., & Chakraborty, T. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2005.08.004 · Cited by 523
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Distinct Effects of Surfactant Protein A or D Deficiency During Bacterial Infection on the Lung
LeVine, A. M., Whitsett, J. A., Gwozdz, J. A., Richardson, T. R., Fisher, J. H., Burhans, M. S., & Korfhagen, T. R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.3934 · Cited by 352
Self-citation
Metadata
- Authors
- LeVine, A. M., Kurak, K. E., Bruno, M. D., Stark, J. M., Whitsett, J. A., & Korfhagen, T. R.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-10-01
- Volume
- 19
- Issue
- 4
- Pages
- 700-708
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2044279773
- Cited by
- 317
- References
- 42
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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