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Interleukin-9 Promotes Allergen-Induced Eosinophilic Inflammation and Airway Hyperresponsiveness in Transgenic Mice
Abstract
Human atopic asthma is a complex heritable inflammatory disorder of the airways associated with clinical signs of allergic inflammation and airway hyperresponsiveness. Recent studies demonstrate that the degree of airway responsiveness is strongly associated with interleukin (IL)-9 expression in murine lung. To investigate the contribution of IL-9 to airway hyperresponsiveness, and to explore directly its relationship to airway inflammation, we studied transgenic mice overexpressing IL-9. In this report we show that IL-9 transgenic mice (FVB/N-TG5), in comparison with FVB/NJ mice, display significantly enhanced eosinophilic airway inflammation, elevated serum total immunoglobulin E, and airway hyperresponsiveness following lung challenge with a natural antigen (Aspergillus fumigatus). These data support a central role for IL-9 in the complex pathogenesis of allergic inflammation.
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Citations
Cited by
Kuperman, D. A., Huang, X., Koth, L. L., Chang, G. H., Dolganov, G. M., Zhu, Z., Elias, J. A., Sheppard, D., & Erle, D. J. (2002) · Nature Medicine · doi:10.1038/nm734 · Cited by 937
T cell responses: naïve to memory and everything in between
Pennock, N. D., White, J. T., Cross, E. W., Cheney, E. E., Tamburini, B. A., & Kedl, R. M. (2013) · Advances in Physiology Education · doi:10.1152/advan.00066.2013 · Cited by 461
New insights into the role of cytokines in asthma
Renauld, J.-C. (2001) · Journal of Clinical Pathology · doi:10.1136/jcp.54.8.577 · Cited by 384
Self-citationHamid, Q., & Tulic, M. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163200 · Cited by 371
Th9 cells: differentiation and disease
Kaplan, M. H. (2013) · Immunological Reviews · doi:10.1111/imr.12028 · Cited by 320
Metadata
- Authors
- McLane, M. P., Haczku, A., van de Rijn, M., Weiss, C., Ferrante, V., MacDonald, D., Renauld, J.-C., Nicolaides, N. C., Holroyd, K. J., & Levitt, R. C.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-11-01
- Volume
- 19
- Issue
- 5
- Pages
- 713-720
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2133041797
- Cited by
- 180
- References
- 0
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Interleukin-9 Promotes Allergen-Induced Eosinophilic Inflammation and Airway Hyperresponsiveness in Transgenic Mice. https://app.cochat.ai/papers/10.1165/ajrcmb.19.5.3457
- The paper
- McLane, M. P., Haczku, A., van de Rijn, M., Weiss, C., Ferrante, V., MacDonald, D., Renauld, J.-C., Nicolaides, N. C., Holroyd, K. J., & Levitt, R. C. (1998). Interleukin-9 Promotes Allergen-Induced Eosinophilic Inflammation and Airway Hyperresponsiveness in Transgenic Mice. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/ajrcmb.19.5.3457
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
