T cell responses: naïve to memory and everything in between
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Antigen-presenting cells must provide costimulatory signals through surface receptors such as CD28 and cytokines such as IL-12 for effective T cell stimulation.
“Apart from the antigen peptides embedded on the MHC molecules, antigen-presenting cells must provide costimulatory signals through surface receptors (such as CD28) and cytokines [such as interleukin (IL)-12] for effective T cell stimulation (2).”
From Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations (2018) · cites this paper as [2]
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- Authors
- Pennock, N. D., White, J. T., Cross, E. W., Cheney, E. E., Tamburini, B. A., & Kedl, R. M.
- Affiliations
- University of Colorado Denver (US)
- Corresponding author
- Kedl, Ross M.
- Venue
- Advances in Physiology Education
- Publisher
- American Physiological Society
- Published
- 2013-12
- Volume
- 37
- Issue
- 4
- Pages
- 273-283
- ISSN
- 1043-4046 (ISSN-L)
- 1522-1229
- PMC
- PMC4089090
- OpenAlex
- W2166332777
- Cited by
- 461
- References
- 99
- Citations by year
- 2026: 21 · 2025: 28 · 2024: 42 · 2023: 67 · 2022: 49 · 2021: 88 · 2020: 57 · 2019: 43 · 2018: 34 · 2017: 22 · 2016: 4 · 2015: 4 · 2014: 2
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- AJP Advances in Physiology Education (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM008497)
- National Institute of Allergy and Infectious Diseases (R01AI101205, T32AI007405)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- T cell response, naive T cells, memory T cells, T cell differentiation, adaptive immunity
- MeSH terms
- Cell Differentiation, Humans, Immunologic Memory, Lymphocyte Activation, T-Lymphocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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