The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Inhaled Particulate Matter Causes Expression of Nuclear Factor (NF)- κ B–Related Genes and Oxidant-Dependent NF- κ B Activation In Vitro
Open accessAbstract
High levels of ambient air pollution are associated with exacerbation of asthma and respiratory morbidity, yet little is known concerning the mechanisms of inflammation and toxicity by components of inhaled particulate matter (PM). Brief inhalation of PM(2.5) (particles of an aerodynamic diameter of < 2.5 microns) (300 microg/m(3) air for 6 h followed by a period of 24 h in clean air) by either C3H/HeJ or C57/BL6 mice caused significant (P </= 0.05) increases in steady-state messenger RNA (mRNA) levels of a number of nuclear factor (NF)-kappaB-associated and/ or -regulated genes, including tumor necrosis factor-alpha and -beta, interleukin-6, interferon-gamma, and transforming growth factor-beta. Lung mRNA levels of lymphotoxin-beta and macrophage migration inhibitory factor were unchanged. In murine C10 alveolar cells and an NF-kappaB-luciferase reporter cell line, exposure to PM(2.5) at noncytotoxic concentrations resulted in increases in transcriptional activation of NF-kappaB-dependent gene expression which were inhibited in the presence of catalase. Early and persistent increases in intracellular oxidants, as measured by flow cytometry and cell imaging using the oxidant probe 2'-7'-dichlorofluoroscin diacetate, were observed in epithelial cells exposed to PM(2.5) and ultrafine carbon black particles. Studies here are the first to show NF-kappaB-related inflammatory and cytokine gene expression after inhalation of PM(2.5) and oxidant-dependent induction of NF-kappaB activity by PM(2.5) in pulmonary epithelial cells.
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Cites
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Cited by
Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181dbece1 · Cited by 6,548
Brook, R. D., Franklin, B., Cascio, W., Hong, Y., Howard, G., Lipsett, M., Luepker, R., Mittleman, M., Samet, J., Smith, S. C., et al. (2004) · Circulation · doi:10.1161/01.cir.0000128587.30041.c8 · Cited by 2,380
Sun, Q. (2005) · JAMA · doi:10.1001/jama.294.23.3003 · Cited by 853
Oxidative stress and air pollution exposure
Lodovici, M., & Bigagli, E. (2011) · Journal of Toxicology · doi:10.1155/2011/487074 · Cited by 720
Cardiovascular effects of air pollution
Brook, R. D. (2008) · Clinical Science · doi:10.1042/cs20070444 · Cited by 657
Metadata
- Authors
- Shukla, A., Timblin, C., BeruBe, K., Gordon, T., McKinney, W., Driscoll, K., Vacek, P., & Mossman, B. T.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-08-01
- Volume
- 23
- Issue
- 2
- Pages
- 182-187
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2019789379
- Cited by
- 275
- References
- 30
- FWCI
- 9.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Shukla, A., Timblin, C., BeruBe, K., Gordon, T., McKinney, W., Driscoll, K., Vacek, P., & Mossman, B. T. (2000). Inhaled Particulate Matter Causes Expression of Nuclear Factor (NF)- κ B–Related Genes and Oxidant-Dependent NF- κ B Activation In Vitro. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/ajrcmb.23.2.4035
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