The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Exposure of Humans to Ambient Levels of Ozone for 6.6 Hours Causes Cellular and Biochemical Changes in the Lung
Abstract
An acute (2 h) exposure of humans to 0.4 ppm ozone initiates biochemical changes in the lung that result in the production of components mediating inflammation and acute lung damage as well as components having the potential to lead to long-term effects such as fibrosis. However, many people are exposed to lower levels of ozone than this, but for periods of several hours. Therefore, it is important to determine if a prolonged exposure to low levels of ozone is also capable of causing cellular and biochemical changes in the lung. Nonsmoking males were randomly exposed to filtered air and either 0.10 ppm ozone or 0.08 ppm ozone for 6.6 h with moderate exercise (40 liters/min). Bronchoalveolar lavage (BAL) was performed 18 h after each exposure, and cells and fluid were analyzed. The BAL fluid of volunteers exposed to 0.10 ppm ozone had significant increases in neutrophils (PMNs), protein, prostaglandin E2 (PGE2), fibronectin, interleukin-6 (IL-6), and lactate dehydrogenase (LDH) compared with BAL fluid from the same volunteers exposed to filtered air. In addition, there was a decrease in the ability of alveolar macrophages to phagocytize yeast via the complement receptor. Exposure to 0.08 ppm ozone resulted in significant increases in PMNs, PGE2, LDH, IL-6, alpha 1-antitrypsin, and decreased phagocytosis via the complement receptor. However, BAL fluid protein and fibronectin were no longer significantly elevated. We conclude that exposure of humans to as low a level as 0.08 ppm for 6.6 h is sufficient to initiate an inflammatory reaction in the lung.
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Cites
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THE PHENOMENON OF THE ACUTE PHASE RESPONSE*
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Macrophages and Polymorphonuclear Neutrophils in Lung Defense and Injury
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Prostaglandins, Arachidonic Acid, and Inflammation
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Ozone-induced inflammation in the lower airways of human subjects
Koren, H. S., Devlin, R. B., Graham, D. E., Mann, R., McGee, M. P., Horstman, D. H., Kozumbo, W. J., Becker, S., House, D. E., McDonnell, W. F., et al. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/139.2.407 · Cited by 499
Self-citationPick, E., & Keisari, Y. (1981) · Cellular Immunology · doi:10.1016/0008-8749(81)90411-1 · Cited by 486
O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans
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The Role of Arachidonic Acid Oxygenation Products in Pain and Inflammation
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Cited by
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*
Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W. J., Togias, A., Zuberbier, T., Baena‐Cagnani, C. E., Canonica, G. W., Van Weel, C., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01620.x · Cited by 4,729
Allergic Rhinitis and Its Impact on Asthma
Bousquet, J., van Cauwenberge, P., & Khaltaev, N. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118891 · Cited by 3,588
Acute Effects of Ozone on Mortality from the “Air Pollution and Health
Gryparis, A., Forsberg, B., Katsouyanni, K., Analitis, A., Touloumi, G., Schwartz, J., Samoli, E., Medina, S., Anderson, H. R., Niciu, E. M., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200403-333oc · Cited by 449
Effect of antioxidant supplementation on ozone-induced lung injury in human subjects
SAMET, J. M., HATCH, G. E., HORSTMAN, D., STECK-SCOTT, S., ARAB, L., BROMBERG, P. A., LEVINE, M., MCDONNELL, W. F., & DEVLIN, R. B. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.5.2008003 · Cited by 164
Self-citationKrishna, M., Madden, J., Teran, L., Biscione, G., Lau, L., Withers, N., Sandstrom, T., Mudway, I., Kelly, F., Walls, A., et al. (1998) · European Respiratory Journal · doi:10.1183/09031936.98.11061294 · Cited by 107
Metadata
- Authors
- Devlin, R. B., McDonnell, W. F., Mann, R., Becker, S., House, D. E., Schreinemachers, D., & Koren, H. S.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-01
- Volume
- 4
- Issue
- 1
- Pages
- 72-81
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2088829977
- Cited by
- 470
- References
- 38
- FWCI
- 23.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Exposure of Humans to Ambient Levels of Ozone for 6.6 Hours Causes Cellular and Biochemical Changes in the Lung. https://app.cochat.ai/papers/10.1165/ajrcmb/4.1.72
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- Devlin, R. B., McDonnell, W. F., Mann, R., Becker, S., House, D. E., Schreinemachers, D., & Koren, H. S. (1991). Exposure of Humans to Ambient Levels of Ozone for 6.6 Hours Causes Cellular and Biochemical Changes in the Lung. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/ajrcmb/4.1.72
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
