The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Cigarette Smoke Alters Chromatin Remodeling and Induces Proinflammatory Genes in Rat Lungs
Abstract
Cigarette smoke-triggered inflammation is considered to play a central role in the development of chronic obstructive pulmonary disease by a mechanism that may involve enhanced proinflammatory gene transcription. Histone acetylation and deacetylation is a key regulator of the specificity and duration of gene transcription. Disruption in the nuclear histone acetylation:deacetylation balance (chromatin remodeling) may result in excessive transcription of specific proinflammatory genes in the lungs. In this study we show that cigarette smoke exposure results in an influx of inflammatory cells and chromatin modifications in rat lungs. This was associated with an increase in the active phosphorylated form of p38 mitogen-activated protein kinase concomitant with increased histone 3 phospho-acetylation, histone 4 acetylation, and increased DNA binding of the redox-sensitive transcription factor nuclear factor-kappaB, independent of inhibitory protein-kappaB degradation, and activator protein 1. We also observed decreased histone deacetylase 2 activity, which is due to protein modification by aldehydes and nitric oxide products present in cigarette smoke. Furthermore, we show that corticosteroid treatment has no effect on smoke-induced proinflammatory mediator release. These findings suggest a possible molecular mechanism by which cigarette smoke drives proinflammatory gene transcription and an inflammatory response in the lungs.
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Histone deacetylases (HDACs): characterization of the classical HDAC family
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Histone acetylation in chromatin structure and transcription
Grunstein, M. (1997) · Nature · doi:10.1038/38664 · Cited by 2,884
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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
Finnin, M. S., Donigian, J. R., Cohen, A., Richon, V. M., Rifkind, R. A., Marks, P. A., Breslow, R., & Pavletich, N. P. (1999) · Nature · doi:10.1038/43710 · Cited by 1,714
Free-radical chemistry of cigarette smoke and its toxicological implications.
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Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation
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Signaling to Chromatin through Histone Modifications
Cheung, P., Allis, C. D., & Sassone-Corsi, P. (2000) · Cell · doi:10.1016/s0092-8674(00)00118-5 · Cited by 989
The Phosphorylation Status of Nuclear NF-ΚB Determines Its Association with CBP/p300 or HDAC-1
Zhong, H., May, M. J., Jimi, E., & Ghosh, S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00477-x · Cited by 939
Cited by
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
Chung, K. F., & Adcock, I. M. (2008) · European Respiratory Journal · doi:10.1183/09031936.00018908 · Cited by 599
Alegría-Torres, J. A., Baccarelli, A., & Bollati, V. (2011) · Epigenomics · doi:10.2217/epi.11.22 · Cited by 587
Rajendrasozhan, S., Yang, S.-R., Kinnula, V. L., & Rahman, I. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1269oc · Cited by 520
Self-citationKode, A., Rajendrasozhan, S., Caito, S., Yang, S.-R., Megson, I. L., & Rahman, I. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00361.2007 · Cited by 447
Self-citationPathogenesis of Chronic Obstructive Pulmonary Disease
MacNee, W. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200504-045sr · Cited by 448
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Metadata
- Authors
- Marwick, J. A., Kirkham, P. A., Stevenson, C. S., Danahay, H., Giddings, J., Butler, K., Donaldson, K., MacNee, W., & Rahman, I.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-12
- Volume
- 31
- Issue
- 6
- Pages
- 633-642
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2116845070
- Cited by
- 301
- References
- 44
- FWCI
- 14.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marwick, J. A., Kirkham, P. A., Stevenson, C. S., Danahay, H., Giddings, J., Butler, K., Donaldson, K., MacNee, W., & Rahman, I. (2004). Cigarette Smoke Alters Chromatin Remodeling and Induces Proinflammatory Genes in Rat Lungs. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/rcmb.2004-0006oc
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