The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
Open accessAbstract
Chronic obstructive pulmonary disease is a leading global cause of morbidity and mortality that is characterised by inexorable deterioration of small airways obstruction with emphysema associated with cellular inflammation and structural remodelling. Other features include apoptosis as well as proliferation of cells, and both tissue repair and lack of tissue repair. Metalloprotease release, together with that of apoptotic factors, may underlie the emphysema, and, conversely, fibrosis of the small airways may be accounted for by the effects of growth factor activation. In advanced disease, influential factors include the development of autoimmunity, with activation of dendritic cells and T-helper cells of both type 1 and 2, and the senescence response. An inability of macrophages to ingest apoptosed cells and bacteria may exacerbate inflammatory responses. Systemic inflammation with concomitant cardiovascular disease and metabolic syndrome may reflect the effect of cigarette smoke on nonpulmonary cells. Corticosteroid resistance may be secondary to oxidative stress mechanisms, such as inactivation of histone deacetylases. The mechanisms of chronic obstructive pulmonary disease may be heterogeneous, according to severity, and clinical phenotypes need to be correlated with cellular and pathological processes. Treatments may be targeted to patients with specific mechanisms.
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Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
Infections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations
Papi, A., Bellettato, C. M., Braccioni, F., Romagnoli, M., Casolari, P., Caramori, G., Fabbri, L. M., & Johnston, S. L. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200506-859oc · Cited by 1,072
Checking on DNA damage in S phase
Bartek, J., Lukas, C., & Lukas, J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1493 · Cited by 758
Elastic fiber homeostasis requires lysyl oxidase–like 1 protein
Liu, X., Zhao, Y., Gao, J., Pawlyk, B., Starcher, B., Spencer, J. A., Yanagisawa, H., Zuo, J., & Li, T. (2004) · Nature Genetics · doi:10.1038/ng1297 · Cited by 663
Ito, K., Yamamura, S., Essilfie-Quaye, S., Cosio, B., Ito, M., Barnes, P. J., & Adcock, I. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050466 · Cited by 638
Self-citationRajendrasozhan, S., Yang, S.-R., Kinnula, V. L., & Rahman, I. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1269oc · Cited by 520
Hodge, S., Hodge, G., Scicchitano, R., Reynolds, P. N., & Holmes, M. (2003) · Immunology & Cell Biology · doi:10.1046/j.1440-1711.2003.t01-1-01170.x · Cited by 440
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Skeletal Muscle Apoptosis and Weight Loss in Chronic Obstructive Pulmonary Disease
Agustí, A. G. N., Sauleda, J., Miralles, C., Gomez, C., Togores, B., Sala, E., Batle, S., & Busquets, X. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2108013 · Cited by 343
Telomere shortening in smokers with and without COPD
Morlá, M., Busquets, X., Pons, J., Sauleda, J., MacNee, W., & Agustí, A. G. N. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00087005 · Cited by 326
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Self-citationSharma, G., Hanania, N. A., & Shim, Y. M. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200904-022rm · Cited by 105
Smoking-induced iron dysregulation in the lung
Zhang, W. Z., Butler, J. J., & Cloonan, S. M. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.07.024 · Cited by 62
Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model
Li, F., Wiegman, C., Seiffert, J. M., Zhu, J., Clarke, C., Chang, Y., Bhavsar, P., Adcock, I., Zhang, J., Zhou, X., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080782 · Cited by 62
Self-citationNano-based theranostics for chronic obstructive lung diseases: challenges and therapeutic potential
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Metadata
- Authors
- Chung, K. F., & Adcock, I. M.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2008-05-30
- Volume
- 31
- Issue
- 6
- Pages
- 1334-1356
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2157409103
- Cited by
- 599
- References
- 13
- FWCI
- 29.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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