B Lymphocytes Are Critical for Lung Fibrosis Control and Prostaglandin E2 Regulation in IL-9 Transgenic Mice

Arras, Mohammed; Louahed, Jamila; Simoen, Vincent; Barbarin, Virginie; Misson, Pierre; van den Brûle, Sybille; Delos, Monique; Knoops, Laurent; Renauld, Jean-Christophe; Lison, Dominique; Huaux, François

doi:10.1165/rcmb.2004-0383oc

B Lymphocytes Are Critical for Lung Fibrosis Control and Prostaglandin E2 Regulation in IL-9 Transgenic Mice

We previously showed that overexpression of IL-9 controls lung fibrosis induced by silica particles in mice (Arras and colleagues; Am J Respir Cell Mol Biol 2001;24:368–375). This protection was associated with an expansion of lung B lymphocytes. To explore the contribution of these cells in the …