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Effective Mucus Clearance Is Essential for Respiratory Health
Open accessAbstract
Studies of the pathogenesis of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD), as well as novel genetic mouse models, vividly illustrate that effective "mucus clearance" is a critical innate airway defense mechanism.Modern physics, physical chemistry, biochemistry, and cell and systems biology are revealing the structure of the mucus clearance apparatus and elucidating key parameters underlying its efficient function.New paradigms are evolving to describe the interaction of the near-cell surface environment with overlying mucus, the dominant role of adequate hydration for effective mucus clearance, the role of nucleotide and nucleoside signaling to regulate airway surface hydration, the physiochemical basis of mucus adhesion, and the pathophysiologic consequences of impaired mucus clearance.The recent success of hypertonic saline to restore surface hydration and improve mucus clearance in CF suggests that novel therapeutic strategies will be similarly efficacious in other airway diseases, including chronic obstructive pulmonary disease (COPD).
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“Low humidity in the respiratory tract leads to impaired mucociliary function and increases the risk of both upper and lower respiratory tract infections [6].”
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“Аккумуляция секрета внутри просвета дыхательных путей может являться результатом повышенной про дукции и секреции муцина [15], сниженного муко цилиарного клиренса [16] и / или сниженной дегра дации муцина в дыхательных путях [17].”
In vivo examination of the cortical cytoskeleton in multiciliated cells using electron tomography
Clare, D. K., Dumoux, M., & Delacour, D. (2015) · Methods in cell biology · doi:10.1016/bs.mcb.2015.03.001 · Cited by 1
“Aberrant motile cilium motion or organization leads to impaired fluid flow and development of hydrocephaly or respiratory disorders (Brooks & Wallingford, 2014; Knowles & Boucher, 2002; Lee, 2013; Randell & Boucher, 2006).”
BackgroundBRONCHIAL SECRETORY IgA DEFICIENCY CORRELATES WITH AIRWAY INFLAMMATION AND PROGRESSION OF COPD
Polosukhin, V. V., Cates, J., Lawson, W. E., Zaynagetdinov, R., Massion, P. P., Ocak, S., Lee, J. W., Bowler, R. P., Randell, S. H., & Blackwell, T. S. (2011) · Cited by 1
Self-citationDesign and Development of Non-invasive Automated mucus Removal Device By Acoustic Assisted Therapy
Bhavani, K. A., & Sujitha, L. (2021) · International Conference on Bio Signals, Images, and Instrumentation (ICBSII) · doi:10.1109/icbsii51839.2021.9445192 · Cited by 1
Dębczyński, M., Gorrieri, G., Mojsak, D., Guida, F., Zara, F., & Scudieri, P. (2023) · Biomolecules · doi:10.3390/biom13101455 · Cited by 1
“The proper composition and properties of the liquid and mucus covering the airways are finely tuned by a series of mechanisms in which the activity of different ion channels and transporters plays a crucial role [16,22].”
BackgroundAerosol deposition in mucus-lined ciliated airways
Hazra, S., & Picardo, J. R. (2025) · Journal of Fluid Mechanics · doi:10.1017/jfm.2025.10606 · Cited by 4
Cystic Fibrosis Pulmonary Exacerbation – Natural History, Causative Factors and Management
Maria, I. B., & Jar, N. (2013) · InTech eBooks · doi:10.5772/54336 · Cited by 1
“Mucus clearance is considered a most important innate airway de‐ fence mechanism (Randell & Boucher, 2006; Knowles & Boucher, 2002), and disruption of the normal mucus secretion and mucociliary clearance impairs lung defence and increases the risk of infection.”
BackgroundThe Place Of Mucolytics In The treatment Of Inflammatory Respiratory Diseases
Kochuiev, G., Кочуева, М. Н., & Корж, А. Н. (2017) · Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini · doi:10.15407/internalmed2017.01.102 · Cited by 1
Effects of Rock Dust Particles on Airway Mucus Viscosity
Tsai, Y.-Y., Vazquez, C. I., Shiu, R.-F., Garcia, A. K., Le, C., Patel, P., Sadqi, M., & Chin, W. (2021) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-020-0236-x · Cited by 1
Inhalation of Insulin for Diabetes Management
Bahman, F., & Taurin, S. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839165498-00165 · Cited by 1
Joshi, M., Majagaiya, B. S., Cheng, H., Yin, J., & Chaudhary, M. (2022) · International Journal of Pregnancy & Child Birth · doi:10.15406/ipcb.2022.08.00259 · Cited by 1
Mycoplasma pneumoniaeAttachment and Colonization of the Respiratory Mucosa
Krause, D. C., Jordan, J. L., Chang, H.-Y., Kyung, P. H., & Krunkosky, T. M. (2007) · doi:10.1128/9781555815851.ch10 · Cited by 1
Kirch, J. (2012) · Publications of the UdS (Saarland University) · doi:10.22028/d291-22833 · Cited by 1
“Recent findings support the hypothesis of the PCL being interfused with tethered mucins, giving it some internal structure (Randell and Boucher, 2006).”
BackgroundResultJónsdóttir, H. R., Marti, S., Geerts, D., Rodriguez, R., Thiel, V., & Dijkman, R. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/694380 · Cited by 1
Pillai, K., Mekkawy, A. H., Akhter, J., Valle, S. J., & Morris, D. L. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.28.474344 · Cited by 1
Greenwald, M. A., Meinig, S. L., Plott, L. M., Roca, C., Higgs, M. G., Vitko, N. P., Markovetz, M. R., Rouillard, K. R., Carpenter, J., Kesımer, M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.20.572620 · Cited by 1
Kenning, J. (2012) · UPT. Syiah Kuala University Library (Syiah Kuala University)
New Insights into the Epithelial Sodium Channel Using Directed Mutagenesis
Chraïbi, A., & Renaul, S. (2013) · InTech eBooks · doi:10.5772/50309
“In lungs, ENaC regulates mucus secretion and aids in the protection of the airway surface (Randell and Boucher, 2006).”
Detection and aerosol treatment of small airway disease in pediatric cystic fibrosis and asthma
van den Beukel-Bakker, M. (2012)
Extraction of desmosines from urine: an indicator for inflammatory lung damage
Winfield, K. (2006) · UWA Profiles and Research Repository (UWA)
and pathogenesis Exacerbations in cystic fibrosis · 1: Epidemiology
Goss, C. H., & Burns, J. L. (2007)
Macrólidos en enfermedades inflamatorias crónicas de las vías respiratorias
Mauricio Moreno, M., Morales, Ó. S., Martínez, C. M., Acosta, F. G., Vela, E. P. V., Garzón, A. M. P., & Jiménez, R. M. (2011) · Revista Colombiana de Neumología · doi:10.30789/rcneumologia.v23.n2.2011.178
Sheridan, J. T. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/pbg3-m139
Ontwennen van mechanische beademing
ter Haar, H. (2016) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-1590-1_12
Defective innate immunity in chronic obstructive pulmonary disease
Thomas, C. M. R. (2013) · doi:10.25560/40171
Modulation of innate immunity in lung epithelium
Kulkarni, N. N. (2016) · Skemman
Metadata
- Authors
- Randell, S. H., & Boucher, R. C.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-07-01
- Volume
- 35
- Issue
- 1
- Pages
- 20-28
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- PMC
- PMC2658694
- OpenAlex
- W2104048715
- Cited by
- 335
- References
- 67
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 17 · 2023: 25 · 2022: 11 · 2021: 21 · 2020: 13 · 2019: 23 · 2018: 16 · 2017: 14 · 2016: 17 · 2015: 11 · 2014: 30 · 2013: 24 · 2012: 24
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Respiratory Cell and Molecular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
- Keywords
- mucus clearance, cystic fibrosis, primary ciliary dyskinesia, mucus adhesion, nucleotide signaling, hypertonic saline, airway defense, chronic obstructive pulmonary disease
- MeSH terms
- Animals, Body Water, Humans, Inflammation, Mucociliary Clearance, Respiratory System, Immunity, Mucosal
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