Cited by 335Cystic Fibrosis Research AdvancesIon Transport and Channel RegulationRespiratory and Cough-Related Research

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Effective Mucus Clearance Is Essential for Respiratory Health

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Randell, Scott H., Boucher, Richard C.·2006·American Journal of Respiratory Cell and Molecular Biology

DOI 10.1165/rcmb.2006-0082sfPMC PMC2658694

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Abstract

Studies of the pathogenesis of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD), as well as novel genetic mouse models, vividly illustrate that effective "mucus clearance" is a critical innate airway defense mechanism.Modern physics, physical chemistry, biochemistry, and cell and systems biology are revealing the structure of the mucus clearance apparatus and elucidating key parameters underlying its efficient function.New paradigms are evolving to describe the interaction of the near-cell surface environment with overlying mucus, the dominant role of adequate hydration for effective mucus clearance, the role of nucleotide and nucleoside signaling to regulate airway surface hydration, the physiochemical basis of mucus adhesion, and the pathophysiologic consequences of impaired mucus clearance.The recent success of hypertonic saline to restore surface hydration and improve mucus clearance in CF suggests that novel therapeutic strategies will be similarly efficacious in other airway diseases, including chronic obstructive pulmonary disease (COPD).

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Authors: Randell, S. H., & Boucher, R. C.
Affiliations: University of North Carolina at Chapel Hill (US)
ORCID: Randell, Scott H.
Boucher, Richard C.
Venue: American Journal of Respiratory Cell and Molecular Biology
Publisher: Oxford University Press (OUP)
Published: 2006-07-01
Volume: 35
Issue: 1
Pages: 20-28
ISSN: 1044-1549 (ISSN-L)
1535-4989
DOI: 10.1165/rcmb.2006-0082sf
PMC: PMC2658694
OpenAlex: W2104048715
Cited by: 335
References: 67
Citations by year: 2026: 9 · 2025: 11 · 2024: 17 · 2023: 25 · 2022: 11 · 2021: 21 · 2020: 13 · 2019: 23 · 2018: 16 · 2017: 14 · 2016: 17 · 2015: 11 · 2014: 30 · 2013: 24 · 2012: 24
FWCI: 2.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory Cell and Molecular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
Keywords: mucus clearance, cystic fibrosis, primary ciliary dyskinesia, mucus adhesion, nucleotide signaling, hypertonic saline, airway defense, chronic obstructive pulmonary disease
MeSH terms: Animals, Body Water, Humans, Inflammation, Mucociliary Clearance, Respiratory System, Immunity, Mucosal

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Effective Mucus Clearance Is Essential for Respiratory Health

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