The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Effective Mucus Clearance Is Essential for Respiratory Health
Open accessAbstract
Studies of the pathogenesis of cystic fibrosis (CF) and primary ciliary dyskinesia (PCD), as well as novel genetic mouse models, vividly illustrate that effective "mucus clearance" is a critical innate airway defense mechanism.Modern physics, physical chemistry, biochemistry, and cell and systems biology are revealing the structure of the mucus clearance apparatus and elucidating key parameters underlying its efficient function.New paradigms are evolving to describe the interaction of the near-cell surface environment with overlying mucus, the dominant role of adequate hydration for effective mucus clearance, the role of nucleotide and nucleoside signaling to regulate airway surface hydration, the physiochemical basis of mucus adhesion, and the pathophysiologic consequences of impaired mucus clearance.The recent success of hypertonic saline to restore surface hydration and improve mucus clearance in CF suggests that novel therapeutic strategies will be similarly efficacious in other airway diseases, including chronic obstructive pulmonary disease (COPD).
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“Low humidity in the respiratory tract leads to impaired mucociliary function and increases the risk of both upper and lower respiratory tract infections [6].”
From Investigating the case of human nose shape and climate adaptation (2017) · cites this paper as [6]
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Cited by
Sorted by citations
Micro- and macrorheology of mucus
Lai, S. K., Wang, Y.-Y., Wirtz, D., & Hanes, J. S. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.09.012 · Cited by 1,268
“An intermediate viscoelasticity of the mucus gel, as well as a low viscosity periciliary fluid (sol) layer, are essential for optimal mucociliary transport [9,32].”
Cilia and Mucociliary ClearancePreprint
Bustamante-Marin, X. M., & Ostrowski, L. E. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028241 · Cited by 896
Shteinberg, M., Haq, I. J., Polineni, D., & Davies, J. C. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32542-3 · Cited by 682
Airway Surface Dehydration in Cystic Fibrosis: Pathogenesis and Therapy
Boucher, R. C. (2007) · Annual Review of Medicine · doi:10.1146/annurev.med.58.071905.105316 · Cited by 528
PEGylation for enhancing nanoparticle diffusion in mucus
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Metadata
- Authors
- Randell, S. H., & Boucher, R. C.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-07-01
- Volume
- 35
- Issue
- 1
- Pages
- 20-28
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- PMC
- PMC2658694
- OpenAlex
- W2104048715
- Cited by
- 335
- References
- 67
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 17 · 2023: 25 · 2022: 11 · 2021: 21 · 2020: 13 · 2019: 23 · 2018: 16 · 2017: 14 · 2016: 17 · 2015: 11 · 2014: 30 · 2013: 24 · 2012: 24
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Respiratory Cell and Molecular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
- Keywords
- mucus clearance, cystic fibrosis, primary ciliary dyskinesia, mucus adhesion, nucleotide signaling, hypertonic saline, airway defense, chronic obstructive pulmonary disease
- MeSH terms
- Animals, Body Water, Humans, Inflammation, Mucociliary Clearance, Respiratory System, Immunity, Mucosal
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