The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Down-Regulated NF-E2–Related Factor 2 in Pulmonary Macrophages of Aged Smokers and Patients with Chronic Obstructive Pulmonary Disease
Abstract
Pulmonary macrophages are one of the sources of various antioxidant and detoxification enzymes for which NF-E2–related factor 2 (Nrf2) is a key transcriptional factor. Although Nrf2 deficiency reportedly induces severe emphysema in mice exposed to cigarette smoke (CS), no reports have studied Nrf2 regulation in chronic obstructive pulmonary disease (COPD). In this study, Nrf2 activation in response to CS was evaluated in human alveolar macrophages, and age-related differences in CS-induced Nrf2 regulation in mouse alveolar macrophages were determined. Furthermore, Nrf2 mRNA levels in human macrophages harvested by bronchoalveolar lavage or laser capture microdissection were measured. CS induced nuclear Nrf2 accumulation and up-regulation of Nrf2 target genes without substantial changes in Nrf2 mRNA levels in human alveolar macrophages. In humans, the Nrf2 mRNA level in lavaged macrophages of young subjects (n = 14) was independent of smoking status; however, the Nrf2 mRNA level was down-regulated in the lavaged macrophages of older current smokers (n = 14) compared with older nonsmokers (n = 9) (P < 0.001). Among older subjects, the macrophage Nrf2 mRNA level was inversely correlated with oxidized glutathione and carbonylated albumin levels in bronchoalveolar lavage fluid. In mice, aging suppressed the CS-induced up-regulation of Nrf2 target genes, as well as Nrf2, in alveolar macrophages. Furthermore, the Nrf2 mRNA level was decreased in laser capture microdissection–retrieved macrophages obtained from subjects with COPD (n = 10) compared with control subjects (n = 10) (P = 0.001). In conclusion, CS induces Nrf2 activation in macrophages, and Nrf2 expression is decreased in the macrophages of older current smokers and patients with COPD.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Experimental studies have illustrated an age-associated increase in ROS levels that corresponds with decreased antioxidative responses in AM (111, 112).”
From Aging and Lung Disease (2020) · cites this paper as [112]
Citations
Cites
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
Self-citationPAUWELS, R. A., Buist, A. S., CALVERLEY, P. M. A., Jenkins, C. R., & Hurd, S. S. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.5.2101039 · Cited by 6,572
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999
Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., Bannai, S., & Yamamoto, M. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16023 · Cited by 1,473
Nrf2 signaling in coordinated activation of antioxidant gene expression
Jaiswal, A. K. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.02.074 · Cited by 1,263
McMahon, M., Itoh, K., Yamamoto, M., & Hayes, J. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300931200 · Cited by 1,141
Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer
Singh, A., Misra, V., Thimmulappa, R. K., Lee, H., Ames, S., Hoque, M. O., Herman, J. G., Baylin, S. B., Sidransky, D., Gabrielson, E., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030420 · Cited by 1,060
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
Thimmulappa, R. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25790 · Cited by 1,028 · cited 1×
“Recently, the Nrf2-ARE system wasshowntoplayan importantrolein theinnateimmune response ( 36 ); this indicates that reduced Nrf2 levels might affect inflammatory responses in older current smokers and/or patients with COPD.”
BackgroundBurden and clinical features of chronic obstructive pulmonary disease (COPD)
PAUWELS, R. A., & Rabe, K. F. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16855-4 · Cited by 1,015
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice
Rangasamy, T., Cho, C. Y., Thimmulappa, R. K., Zhen, L., Srisuma, S., Kensler, T. W., Yamamoto, M. P., Petrache, I., Tuder, R. M., & Biswal, S. S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21146 · Cited by 993
Flagged first, then by citations
Research works printed but not linked: 1
- 2004, J Clin Invest, 114, 1248, 10.1172/JCI200421146 · DOI
Cited by
Sorted by citations
Items 201–286 of 286
Spagnolo, P., & Semenzato, U. (2022) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000876 · Cited by 16
Dalle‐Donne, I., Colombo, G., Gornati, R., Garavaglia, M. L., Portinaro, N. M., Giustarini, D., Bernardini, G., Rossi, R., & Milzani, A. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6772 · Cited by 16
de Toledo, A. C., Neto, I. V. D. S., Vieira, R. P., Guarnier, F. A., Caleman-Neto, A., Suehiro, C. L., Olivo, C. R., Cecchini, R., Prado, C. M., Lin, C. J., et al. (2020) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0543 · Cited by 15
Handa, J. T., Tagami, M., Ebrahimi, K. B., Leibundgut, G., Janiak, A., Witztum, J. L., & Tsimikas, S. (2015) · Europe PMC (PubMed Central) · Cited by 15
Cui, Y., Li, Y., Huang, N., Xiong, Y., Cao, R., Meng, L., Liu, J., & Feng, Z. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.033 · Cited by 14
Callaway, D. A., Jiang, W., Wang, L., Lingappan, K., & Moorthy, B. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.027 · Cited by 13
Drosophila Trachea as a Novel Model of COPD
Scholl, A., Ndoja, I., & Jiang, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312730 · Cited by 13
Sarkar, A., Sharma, S., Agnihotri, P., Sarkar, T., Kumari, P., Malhotra, R., Datta, B., Kumar, V. L., & Biswas, S. (2020) · Journal of Immunology Research · doi:10.1155/2020/4897983 · Cited by 12
Li, X., Luo, B., Wang, L. J., Zhang, W., & Liu, Z. G. (2015) · Genetics and Molecular Research · doi:10.4238/2015.october.29.22 · Cited by 12
Ban, W. H., Kang, H. H., Kim, I. K., Ha, J. H., Joo, H., Lee, J. M., Lim, J. U., Lee, S. H., & Rhee, C. K. (2018) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2017.030 · Cited by 12
Liu, Y., Huang, Z., Li, M., Li, Z., & Chen, K. (2021) · PubMed · doi:10.14670/hh-18-283 · Cited by 12
Khaled, S. S., Makled, M. N., & Nader, M. A. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16093-6 · Cited by 12
RetractedRole of Nuclear Factor Erythroid 2‒Related Factor 2 in Chronic Obstructive Pulmonary Disease
Ban, W. H., & Rhee, C. K. (2022) · Tuberculosis & respiratory diseases · doi:10.4046/trd.2021.0162 · Cited by 11
Martin, R., Marek, N., Anna, L., Olivia, P., Bjermer, L. H., Westergren‐Thorsson, G., Tufvesson, E., & Larsson‐Callerfelt, A. (2024) · Respiratory Research · doi:10.1186/s12931-024-02907-x · Cited by 11
Wang, L., Chen, Q., Liu, T., Bai, T., Zhang, M., Hu, Y., Li, J., & Chang, F. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04353-y · Cited by 11
Smoking and Age‐Related Macular Degeneration
Willeford, K. T., & Rapp, J. (2012) · Optometry and Vision Science · doi:10.1097/opx.0b013e31826c5df2 · Cited by 11
Nrf2, NF-κB and PPARβ/δ mRNA Expression Profile in Patients with Coronary Artery Disease
Barbosa, J. E., Stockler‐Pinto, M. B., Cruz, B. O. D., da Silva, A. C. T., dos Anjos, J. S., Mesquita, C. T., Mafra, D., & Cardozo, L. (2019) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20190125 · Cited by 14
Aging in chronic lung disease: Will anti-aging therapy be the key to the cure?
Wang, W., Zhou, K., Wang, L., Qin, Q., Liu, H., Qin, L., Yang, M., Yuan, L., & Liu, C. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176846 · Cited by 10
Komínková, E., Petřek, M., & Navrátilová, Z. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1492256 · Cited by 10
Delayed cortical bone healing due to impaired nuclear Nrf2 translocation in COPD mice
Nabeshima, T., Tsukamoto, M., Wang, K., Mano, Y., Arakawa, D., Kosugi, K., Tajima, T., Yamanaka, Y., Suzuki, H., Kawasaki, M., et al. (2023) · Bone · doi:10.1016/j.bone.2023.116804 · Cited by 10
Kudo, K., Hata, J., Matsumoto, K., Shundo, Y., Fukuyama, S., Inoue, H., Kitazono, T., Kiyohara, Y., Ninomiya, T., & Nakanishi, Y. (2017) · Circulation Journal · doi:10.1253/circj.cj-16-1305 · Cited by 9
Mechanisms of Action of Curcumin on Aging
Carvalho, A. C., Gomes, A. C., Pereira‐Wilson, C., & Lima, C. F. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00035-2 · Cited by 10
Hara, Y., Shinkai, M., Taguri, M., Nagai, K., Hashimoto, S., & Kaneko, T. (2018) · Canadian Respiratory Journal · doi:10.1155/2018/9627420 · Cited by 10
Self-citationChen, P., Xiao, Z., Wu, H., Wang, Y., Fan, W., Su, W., & Li, P. (2020) · Molecules · doi:10.3390/molecules25204704 · Cited by 10
Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD
Sato, M., Suzuki, M., Kimura, H., Ge, H., Matsumoto, M., Makita, H., Arai, S., Miyazaki, T., Nishimura, M., & Konno, S. (2023) · Respiratory Research · doi:10.1186/s12931-023-02508-0 · Cited by 10
Self-citationZhang, Q., Yan, L., Lu, J., & Zhou, X. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.925700 · Cited by 9
Murata, E., Yoshida, T., Tomaru, U., Yamamoto, S., Fukui‐Miyazaki, A., Ishizu, A., & Kasahara, M. (2024) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2024.104891 · Cited by 9
Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers
Sasaki, H., Suzuki, A., Shitara, M., Hikosaka, Y., Okuda, K., Moriyama, S., Yano, M., & Fujii, Y. (2013) · Biomedical Reports · doi:10.3892/br.2013.83 · Cited by 9
Cong, P., Tong, C., Liu, Y., Shi, L., Shi, X., Zhao, Y., Xiao, K., Jin, H., Liu, Y., & Hou, M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8460290 · Cited by 9
Easwaran, M., Martinez, J. D., Kim, J. B., & Erickson, E. (2022) · Scientific Reports · doi:10.1038/s41598-022-23359-7 · Cited by 9
Heme Oxygenase-1 in Patients With Interstitial Lung Disease: A Review of the Clinical Evidence
Hara, Y., Nakashima, K., Nagasawa, R., Murohashi, K., Tagami, Y., Aoki, A., Okudela, K., & Kaneko, T. (2021) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2021.02.009 · Cited by 8
Qi, X., Walton, D. A., Plafker, K. S., Boulton, M. E., & Plafker, S. M. (2022) · PubMed Central · Cited by 7
Environmental Determinants of Lung Aging
Green, F. H. Y., & Pinkerton, K. E. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-799941-8.00027-4 · Cited by 7
Ying, Y., Lin, X., Zhou, H., Wu, Y., Yan, F., Hua, W., Xia, L., Qiu, Z., Chen, Z., Li, W., et al. (2014) · Microbes and Infection · doi:10.1016/j.micinf.2014.08.014 · Cited by 7
Transcription inhibitors and inflammatory cell activity
Caramori, G., Coppolino, I., Cannavò, M. F., Nucera, F., Proietto, A., Mumby, S. E., Ruggeri, P., & Adcock, I. M. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.05.006 · Cited by 7
Roger, I., Estornut, C., Montero, P., Aparici, M., Puig, C., Davis, A. M., Alberício, F., de Diego, A., Milara, J., & Cortijo, J. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178716 · Cited by 7
Chronic Obstructive Pulmonary Disease
Aoshiba, K., & Nakamura, H. (2016) · Respiratory disease series · doi:10.1007/978-981-10-0839-9 · Cited by 7
Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation
Naidu, S. D., Angelova, P. R., Knatko, E. V., Leonardi, C., Novak, M. J., de la Vega, L., Ganley, I. G., Abramov, A. Y., & Dinkova‐Kostova, A. T. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.09.009 · Cited by 7
Allelic Variants of NRF2 and TLR9 Genes in Critical Illness
Чумаченко, А. Г., Miazin, A. E., Kuzovlev, A. N., Михайлович, Г. А., Tutelyan, A. V., Porokhovnik, L. N., Golubev, A. M., & Писарев, В. М. (2016) · General Reanimatology · doi:10.15360/1813-9779-2016-4-8-23 · Cited by 5
APR3 modulates oxidative stress and mitochondrial function in ARPE‐19 cells
Li, Y., Zou, X., Gao, J., Cao, K. J., Feng, Z., & Liu, J. (2018) · The FASEB Journal · doi:10.1096/fj.201800001rr · Cited by 5
Jaramillo‐Rangel, G., Chávez-Briones, M.-D.-L., Ancer-Arellano, A., Miranda-Maldonado, I. C., & Ortega‐Martínez, M. (2023) · Biomedicines · doi:10.3390/biomedicines11072075 · Cited by 6
Mise, A. D., Wang, Y.-X., & Zheng, Y. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-63245-2_2 · Cited by 5
Insight into Nrf2: a bibliometric and visual analysis from 2000 to 2022
Ma, Y., Wang, Z., & Hu, Y. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1266680 · Cited by 4
Smoking, Oxidative/Carbonyl Stress, and Regulation of Redox Signaling in Lung Inflammation
Sundar, I. K., Yao, H., Kirkham, P., & Rahman, I. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_65 · Cited by 4
Smoking and COPD and Other Respiratory Diseases
Sussan, T. E., & Biswal, S. S. (2011) · doi:10.1002/9783527635320.ch9 · Cited by 4
Zhang, Z., Yu, H.-D., Sai, X., Qin, C., Ding, Y., & Bian, T. (2025) · International Journal of COPD · doi:10.2147/copd.s524465 · Cited by 3
Mariani, T. J., & Martínez, F. J. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201302-0340ed · Cited by 3
Maruoka, H., Tanaka, K., Takayanagi, M., & Zenda, M. (2021) · doi:10.34363/jocp.51.1_35 · Cited by 3
Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions
Zhang, Y., Yu, X., Li, P., Ouyang, Y., Zhu, L., & Luo, F. (2026) · BMC Medicine · doi:10.1186/s12916-026-04833-9 · Cited by 2
Dog allergen-induced asthma in mice: a relevant model of T2low severe asthma with airway remodelling
Margelidon-Cozzolino, V., Balsamelli, J., Carrard, J., Yahia, S. A., Gevaert, M.-H., Demoulin‐Alexikova, S., Pichavant, M., Tsicopoulos, A., Chenivesse, C., Lejeune, S., et al. (2025) · Inflammation Research · doi:10.1007/s00011-025-02004-9 · Cited by 2
Oxidative Stress and Respiratory Diseases: The Critical Role of Nrf2
Sussan, T. E., & Biswal, S. S. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0497-6_17 · Cited by 2
The Relationship Between Oxidative Stress Responses and Lung Inflammation with Cigarette Smoking
Song, C.-C., & Kelsen, S. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7351-0_5 · Cited by 2
MacNee, W., Vestbo, J., & Agustí, A. G. N. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-3383-5.00043-9 · Cited by 2
WITHDRAWN: Cigarette smoke induces alterations in the drug binding properties of human serum albumin
Clerici, M., Colombo, G., Secundo, F., Gagliano, N., Colombo, R., Portinaro, N. M., Giustarini, D., Milzani, A., Rossi, R., & Dalle‐Donne, I. (2014) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2014.04.009 · Cited by 2
RetractedCellular Response to Cigarette Smoke and Oxidants
Cantin, A. M. (2012) · Proceedings of the American Thoracic Society · Cited by 1
Borrelli, E. (2019) · Springer eBooks · doi:10.1007/978-981-32-9366-3_18 · Cited by 1
Regulation of Antioxidant Nrf2 Signaling: An Important Pathway in COPD
Chatterjee, N., & Chatterjee, D. (2019) · Springer eBooks · doi:10.1007/978-981-32-9366-3_7 · Cited by 1
Chen, P., Xiao, Z., Wu, H., Wang, Y., Su, W., & Li, P. (2020) · Natural Product Communications · doi:10.1177/1934578x20947233 · Cited by 1
Oxidative Lung Injury in Virus-Induced Wheezing
Garofalo, R. P. (2012) · doi:10.21236/ada581779 · Cited by 1
Developmental and Physiologicalaging of the Lung
Pinkerton, K. E., Wang, L., Smiley‐Jewell, S. M., Xu, J., & Green, F. H. Y. (2014) · doi:10.1002/9781118396292.ch8 · Cited by 1
Sevilla‐Montero, J., Pino-Fadón, J., Munar-Rubert, O., Villegas-Esguevillas, M., Climent, B., Agrò, M., Choya-Foces, C., Martínez-Ruiz, A., Balsa, E., Muñoz, C., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.21.481310 · Cited by 1
Caramori, G., Nucera, F., Coppolino, I., Bello, F. L., Ruggeri, P., Ito, K., Stefano, A. D., & Adcock, I. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11699-x · Cited by 1
Modulation of Oxidative Stress by Keap1/Nrf2 Signaling inDrosophila: Implications for Human Diseases
Sykiotis, G. P., Rahman, M. M., & Bohmann, D. (2011) · Wiley eBooks · doi:10.1002/9781118148143.ch22
Stockler‐Pinto, M. B., Fouque, D. P., Soulage, C. O., Croze, M. L., & Mafra, D. (2013)
1. Recent Topics on Pathogenesis of COPD
Suzuki, M., & Nishimura, M. (2015) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.104.1074
Self-citationGenomics in the Evaluation and Management of Chronic Obstructive Pulmonary Disease
Barnes, P. J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374934-5.00047-7
Cigarette Smoke‐Induced Protein Carbonylation
Colombo, G., Garavaglia, M. L., Milzani, A., & Dalle‐Donne, I. (2017) · doi:10.1002/9781119374947.ch9
Абатуров, А. Е., Волосовець, О. П., & Borysovа, T. P. (2017) · CHILD`S HEALTH · doi:10.22141/2224-0551.12.6.2017.112843
Macrophage plasticity in chronic obstructive pulmonary disease
Day, A. (2016) · Spiral (Imperial College London) · doi:10.25560/68514
Laudański, K., Mahmoud, M. A., Sayed, A., Susztak, K., Mathew, A., & Chen, J. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073714
Environmental determinants of lung aging
Green, F. H. Y., Saleem, R., Andino, A. L., & Pinkerton, K. E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91824-4.00013-7
Reihani, A., Jahani, D., Shaki, F., & Shokrzadeh, M. (2025) · Applied In Vitro Toxicology · doi:10.1089/aivt.2024.0028
Exercise and Epigenetic Regulation in COPD: Current Evidence and Potential Mechanistic Pathways
Zhong, Y., Xu, J.-H., Chen, X., Lv, Y., & Zheng, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311392 · Cited by 2
Takimoto-Sato, M., Suzuki, M., Kimura, H., Ge, H., Matsumoto, M., Makita, H., Arai, S., Miyazaki, T., Nishimura, M., & Konno, S. (2023) · Figshare · doi:10.6084/m9.figshare.23983376
Self-citationMartin, R., Marek, N., Anna, L., Olivia, P., Leif, B., Gunilla, W.-T., Tufvesson, E., & Anna-Karin, L.-C. (2024) · Figshare · doi:10.6084/m9.figshare.26315701
Martin, R., Marek, N., Anna, L., Olivia, P., Leif, B., Gunilla, W.-T., Tufvesson, E., & Anna-Karin, L.-C. (2024) · Figshare · doi:10.6084/m9.figshare.26315477
Martin, R., Marek, N., Anna, L., Olivia, P., Leif, B., Gunilla, W.-T., Tufvesson, E., & Anna-Karin, L.-C. (2024) · Figshare · doi:10.6084/m9.figshare.26750144
Martin, R., Marek, N., Anna, L., Olivia, P., Leif, B., Gunilla, W.-T., Tufvesson, E., & Anna-Karin, L.-C. (2024) · Figshare · doi:10.6084/m9.figshare.26750141
Charles‐Messance, H. (2018) · theses.fr (ABES) · doi:10.70675/674377b7z4bf8z451cz9328zbe6648512747
Fei-xue, H., He, J.-K., Xiong, J., Long, Y., Peng, Z.-J., Kang, X.-Z., Song, C.-Q., & Wang, G.-F. (2026) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2026.2669200
Timasheva, Y., Korytina, G. F., Markelov, V. A., Насибуллин, Т. Р., Akhmadishina, L. Z., Aznabaeva, Y. G., Рустэмович, З. Ш., Kochetova, O. V., & Zagidullin, N. S. (2026) · Genes · doi:10.3390/genes17060685 · Cited by 1
Корытина, Г. Ф., Akhmadishina, L. Z., Насибулин, Т. Р., Markelov, V. A., Aznabaeva, Y. G., Эрдман, В. В., Zharina, M. A., Кочетова, О. В., & Zagidullin, N. S. (2026) · Russian Journal of Genetics · doi:10.1134/s1022795426700602
Yang, S., Li, R., Yu, C., Li, J., & Zhou, X. (2026) · MedComm · doi:10.1002/mco2.71031
Park, S. B., Yook, T., Rashid, M. U. U., Lee, K., Kim, J. U., Kim, D. Y., Kim, M. H., Jang, J.-Y., & Yang, G. (2026) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2026.10.014
Metadata
- Authors
- Suzuki, M., Betsuyaku, T., Ito, Y., Nagai, K., Nasuhara, Y., Kaga, K., Kondo, S., & Nishimura, M.
- Affiliations
- Hokkaido University (JP)
- First Department of Medicine and
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-12-01
- Volume
- 39
- Issue
- 6
- Pages
- 673-682
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2095835362
- Cited by
- 286
- References
- 38
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 13 · 2023: 11 · 2022: 14 · 2021: 20 · 2020: 23 · 2019: 14 · 2018: 11 · 2017: 18 · 2016: 22 · 2015: 12 · 2014: 17 · 2013: 23 · 2012: 17
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory Cell and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Keywords
- Nrf2, lung macrophages, alveolar macrophages, chronic obstructive pulmonary disease, cigarette smoke, aging, Nrf2 target genes, glutathione disulfide, oxidative stress, antioxidant defense, emphysema
- MeSH terms
- Adult, Aged, Aging, Animals, Bronchoalveolar Lavage Fluid, Female, Humans, Immunohistochemistry, Lung, Male, Mice, Inbred C57BL, Mice, Inbred ICR, Middle Aged, RNA, Messenger, Smoking, Biomarkers, Down-Regulation, Macrophages, Alveolar, Oxidative Stress, Pulmonary Disease, Chronic Obstructive, NF-E2-Related Factor 2, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review