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Ophthalmic Drug Delivery through Contact Lenses
Abstract
PURPOSE: Currently available ophthalmic drug delivery systems are inefficient and may lead to side effects. To increase efficiency and reduce side effects, the authors propose disposable particle-laden soft contact lenses for ophthalmic drug delivery. METHODS: The essential idea is to encapsulate the ophthalmic drug formulations in nanoparticles and to disperse these drug-laden particles in the lens material, such as poly-2-hydroxyethyl methacrylate (p-HEMA) hydrogels. The drug-laden p-HEMA hydrogels were synthesized by free radical solution polymerization of the monomers in presence of nanoparticles. The particle-laden hydrogels were characterized by light-transmission and electron microscopy studies. Release profiles of lidocaine, a model hydrophobic drug, were measured by UV-Vis spectrophotometry. RESULTS: Microemulsions of hexadecane in water stabilized with a silica shell around the particles produced transparent hydrogels. Contact lenses made with particle-laden hydrogels released therapeutic levels of drug for a few days. CONCLUSIONS: Particle-laden hydrogels are promising candidates for ophthalmic drug delivery. They are transparent and can release drugs for extended periods. The drug delivery rates can be controlled by varying the loading of nanoparticles in the gel.
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Cited by
Gaudana, R., Ananthula, H. K., Parenky, A., & Mitra, A. K. (2010) · The AAPS Journal · doi:10.1208/s12248-010-9183-3 · Cited by 1,406
Ocular drug delivery systems: An overview
Patel, A. (2013) · World Journal of Pharmacology · doi:10.5497/wjp.v2.i2.47 · Cited by 890
Ocular drug delivery: present innovations and future challenges
Gote, V., Sikder, S., Sicotte, J., & Pal, D. (2019) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.256933 · Cited by 441
Nanoparticles for drug delivery to the anterior segment of the eye
Janagam, D. R., Wu, L., & Lowe, T. L. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.001 · Cited by 341
Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: A review
Xinming, L., Yingde, C., Lloyd, A. W., Mikhalovsky, S. V., Sandeman, S. R., Howel, C. A., & Liewen, L. (2008) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2007.09.002 · Cited by 306
Metadata
- Authors
- Gulsen, D., & Chauhan, A.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2004-07-01
- Volume
- 45
- Issue
- 7
- Pages
- 2342
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W1993763188
- Cited by
- 304
- References
- 0
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- closed
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