The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
High-Resolution Imaging with Adaptive Optics in Patients with Inherited Retinal Degeneration
Abstract
PURPOSE: To investigate macular photoreceptor structure in patients with inherited retinal degeneration using high-resolution images and to correlate the findings with clinical phenotypes and genetic mutations. METHODS: Adaptive optics scanning laser ophthalmoscopy (AOSLO) images of photoreceptors were obtained in 16 eyes: five with retinitis pigmentosa (RP), three with cone-rod dystrophy (CRD), and eight without retinal disease. A quadratic model was used to illustrate cone spacing as a function of retinal eccentricity. Cone spacing at 1 degrees eccentricity was compared with standard measures of central visual function, including best-corrected visual acuity (BCVA), foveal threshold, and multifocal electroretinogram (mfERG) amplitude and timing. Intervisit variations were studied in one patient with RP and one patient with CRD. Screening of candidate disease genes identified mutations in two patients, one with RP (a rhodopsin mutation) and the other with CRD (a novel RPGR-ORF15 mutation). RESULTS: Cone spacing values were significantly different from normal for patients with RP (P = 0.01) and CRD (P < 0.0001) and demonstrated a statistically significant correlation with foveal threshold (P = 0.0003), BCVA (P = 0.01), and mfERG amplitude (P = 0.008). Although many RP patients showed normal cone spacing within 1 degrees of fixation, cones could not be unambiguously identified in several retinal regions. Cone spacing increased in all CRD patients, even those with early disease. Little variation was observed in cone spacing measured during two sessions fewer than 8 days apart. CONCLUSIONS: AOSLO images can be used to study macular cones with high resolution in patients with retinal degeneration. The authors present the first report of cone structure in vivo in patients with mutations in rhodopsin and RPGR-ORF15 and show that macular cones display distinct characteristics, depending on the underlying disease. AOSLO imaging, therefore, can provide new insight into possible mechanisms of cone vision loss in patients with retinal degeneration.
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Cites
Human photoreceptor topography
Curcio, C. A., Sloan, K. R., Kalina, R. E., & Hendrickson, A. E. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902920402 · Cited by 2,790
Supernormal vision and high-resolution retinal imaging through adaptive optics
Liang, J., Williams, D. R., & Miller, D. T. (1997) · Journal of the Optical Society of America A · doi:10.1364/josaa.14.002884 · Cited by 1,454
The arrangement of the three cone classes in the living human eye
Roorda, A., & Williams, D. R. (1999) · Nature · doi:10.1038/17383 · Cited by 982
Self-citationAdaptive optics scanning laser ophthalmoscopy
Roorda, A., Romero-Borja, F., Donnelly III, W. J., Queener, H., Hebert, T. J., & Campbell, M. C. W. (2002) · Optics Express · doi:10.1364/oe.10.000405 · Cited by 967
Self-citationStandard for clinical electroretinography
Marmor, M. F., Arden, G. B., Nilsson, S.-E., Zrenner, E., & International Standardization Committee (1989) · Documenta Ophthalmologica · doi:10.1007/bf00154486 · Cited by 806
Aberrations and retinal image quality of the normal human eye
Liang, J., & Williams, D. R. (1997) · Journal of the Optical Society of America A · doi:10.1364/josaa.14.002873 · Cited by 764
Three-dimensional Retinal Imaging with High-Speed Ultrahigh-Resolution Optical Coherence Tomography
Wojtkowski, M., Srinivasan, V., Fujimoto, J. G., Ko, T., Schuman, J. S., Kowalczyk, A., & Duker, J. S. (2005) · Ophthalmology · doi:10.1016/j.ophtha.2005.05.023 · Cited by 640
Confocal scanning laser ophthalmoscope
Webb, R. H., Hughes, G. W., & Delori, F. C. (1987) · Applied Optics · doi:10.1364/ao.26.001492 · Cited by 597
Standard for clinical electroretinography (2004 update)
Marmor, M. F., Holder, G. E., Seeliger, M. W., & Yamamoto, S. (2004) · Documenta Ophthalmologica · doi:10.1023/b:doop.0000036793.44912.45 · Cited by 505
Identification and characterization of rod-derived cone viability factor
Léveillard, T., Mohand-Saïd, S., Lorentz, O., Hicks, D., Fintz, A.-C., Clérin, E., Simonutti, M., Forster, V., Cavusoglu, N., Chalmel, F., et al. (2004) · Nature Genetics · doi:10.1038/ng1386 · Cited by 438
Cited by
Cehajic-Kapetanovic, J., Xue, K., Martinez-Fernandez de la Camara, C., Nanda, A., Davies, A., Wood, L. J., Salvetti, A. P., Fischer, M. D., Aylward, J. W., Barnard, A. R., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0763-1 · Cited by 368
Metadata
- Authors
- Duncan, J. L., Zhang, Y., Gandhi, J., Nakanishi, C., Othman, M., Branham, K. E. H., Swaroop, A., & Roorda, A.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2007-07-01
- Volume
- 48
- Issue
- 7
- Pages
- 3283
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W2044404404
- Cited by
- 262
- References
- 44
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Duncan, J. L., Zhang, Y., Gandhi, J., Nakanishi, C., Othman, M., Branham, K. E. H., Swaroop, A., & Roorda, A. (2007). High-Resolution Imaging with Adaptive Optics in Patients with Inherited Retinal Degeneration. Investigative Opthalmology & Visual Science. https://doi.org/10.1167/iovs.06-1422
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