Accelerated Accumulation of Lipofuscin Pigments in the RPE of a Mouse Model for ABCA4-Mediated Retinal Dystrophies following Vitamin A Supplementation

A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Starqardt macular dystrophy

Allikmets, R., Singh, N., Sun, H., Shroyer, N. F., Hutchinson, A., Chidambaram, A., Gerrard, B., Baird, L., Stauffer, D., Peiffer, A., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-236 · Cited by 1,435 · see citing works

In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics.

Delori, F. C., Dorey, C. K., Staurenghi, G., Arend, O., Goger, D. G., & Weiter, J. J. (1995) · PubMed · Cited by 938 · see citing works

Insights into the Function of Rim Protein in Photoreceptors and Etiology of Stargardt's Disease from the Phenotype in abcr Knockout Mice

Weng, J., Mata, N. L., Azarian, S. M., Tzekov, R. T., Birch, D. G., & Travis, G. H. (1999) · Cell · doi:10.1016/s0092-8674(00)80602-9 · Cited by 881 · cited 1× · see citing works

The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

Sparrow, J. R., Nakanishi, K., & Parish, C. A. (2000) · PubMed · Cited by 566 · see citing works

Isolation and one-step preparation of A2E and <i>iso</i> -A2E, fluorophores from human retinal pigment epithelium

Parish, C. A., Hashimoto, M., Nakanishi, K., Dillon, J., & Sparrow, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14609 · Cited by 474 · see citing works

Retinal age pigments generated by self-assembling lysosomotropic detergents

Eldred, G. E., & Lasky, M. R. (1993) · Nature · doi:10.1038/361724a0 · Cited by 461 · see citing works

A Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa

Marmor, M. F. (1993) · Archives of Ophthalmology · doi:10.1001/archopht.1993.01090110018004 · Cited by 460 · see citing works

Biosynthesis of a major lipofuscin fluorophore in mice and humans with <i>ABCR</i> -mediated retinal and macular degeneration

Mata, N. L., Weng, J., & Travis, G. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130110497 · Cited by 456 · see citing works

Prevalence of Retinitis Pigmentosa in Maine

Bunker, C. H., Berson, E. L., Bromley, W. C., Hayes, R. P., & Roderick, T. H. (1984) · American Journal of Ophthalmology · doi:10.1016/0002-9394(84)90636-6 · Cited by 449 · see citing works

Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects.

Delori, F. C., Goger, D. G., & Dorey, C. K. (2001) · PubMed · Cited by 424 · see citing works

Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium

Jin, M., Li, S., Moghrabi, W. N., Sun, H., & Travis, G. H. (2005) · Cell · doi:10.1016/j.cell.2005.06.042 · Cited by 424 · see citing works

Dietary Reference Intakes for The Antioxidant Nutrients

MONSEN, E. R. (2000) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(00)00189-9 · Cited by 357 · see citing works

Retinal Stimulates ATP Hydrolysis by Purified and Reconstituted ABCR, the Photoreceptor-specific ATP-binding Cassette Transporter Responsible for Stargardt Disease

Sun, H., Molday, R. S., & Nathans, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8269 · Cited by 353 · see citing works

Age-related Macular Degeneration

Suter, M., Remé, C., Grimm, C., Wenzel, A., Jäättelä, M., Esser, P., Kociok, N., Leist, M., & Richter, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007049200 · Cited by 315 · see citing works

A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.

Sparrow, J. R., Parish, C. A., Hashimoto, M., & Nakanishi, K. (1999) · PubMed · Cited by 312 · see citing works

The 220-kDa Rim Protein of Retinal Rod Outer Segments Is a Member of the ABC Transporter Superfamily

Illing, M., Molday, L. L., & Molday, R. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.10303 · Cited by 304 · see citing works

Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin.

Schütt, F., Davies, S., Kopitz, J., Holz, F. G., & Boulton, M. (2000) · PubMed · Cited by 292 · see citing works

Retinal Pigment Epithelial Abnormalities in Fundus Flavimmaculatus

Eagle, R. C., Lucier, A. C., Bernardino, V. B., & Yanoff, M. (1980) · Ophthalmology · doi:10.1016/s0161-6420(80)35106-3 · Cited by 287 · see citing works

The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium

Finnemann, S. C., Leung, L. W., & Rodriguez-Boulan, E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052025899 · Cited by 283 · see citing works

A2E-epoxides Damage DNA in Retinal Pigment Epithelial Cells

Sparrow, J. R., Vollmer-Snarr, H. R., Zhou, J., Jang, Y. P., Steffen Jockusch, B., Itagaki, Y., & Nakanishi, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300457200 · Cited by 280 · see citing works

Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2.

Sparrow, J. R., & Cai, B. (2001) · PubMed · Cited by 269 · see citing works

Stargardt's ABCR is localized to the disc membrane of retinal rod outer segments

Sun, H., & Nathans, J. (1997) · Nature Genetics · doi:10.1038/ng0997-15 · Cited by 251 · see citing works

Classification of Fundus Autofluorescence Patterns in Early Age-Related Macular Disease

Bindewald-Wittich, A., Bird, A. C., Dandekar, S. S., Dolar-Szczasny, J., Dreyhaupt, J., Fitzke, F. W., Einbock, W., Holz, F. G., Jorzik, J. J., Keilhauer, C. N., et al. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0430 · Cited by 238 · see citing works

Rod phototransduction in retinitis pigmentosa: estimation and interpretation of parameters derived from the rod a-wave.

Hood, D. C., & Birch, D. G. (1994) · PubMed · Cited by 235 · see citing works

Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration

Radu, R. A., Mata, N. L., Nusinowitz, S., Liu, X., Sieving, P. A., & Travis, G. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737855100 · Cited by 227 · see citing works

Reductions in Serum Vitamin A Arrest Accumulation of Toxic Retinal Fluorophores: A Potential Therapy for Treatment of Lipofuscin-Based Retinal Diseases

Radu, R. A., Han, Y., Bui, T. V., Nusinowitz, S., Bok, D., Lichter, J. B., Widder, K., Travis, G. H., & Mata, N. L. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0820 · Cited by 225 · see citing works

Delayed dark-adaptation and lipofuscin accumulation in abcr+/- mice: implications for involvement of ABCR in age-related macular degeneration.

Mata, N. L., Tzekov, R. T., Liu, X., Weng, J., Birch, D. G., & Travis, G. H. (2001) · PubMed · Cited by 219 · see citing works

Histopathology and immunocytochemistry of the neurosensory retina in fundus flavimaculatus.

Birnbach, C., Järveläínen, M., Possin, D., & Milam, A. (1994) · Ophthalmology (Rochester, Minn.) · doi:10.1016/s0161-6420(13)31725-4 · Cited by 212 · see citing works

Formation of a Nonaoxirane from A2E, a Lipofuscin Fluorophore related to Macular Degeneration, and Evidence of Singlet Oxygen Involvement This work was supported by NIH grant GM 34509 (K.N.), NSF grant NSF-CHE-98-12676 (N.J.T. and S.J.), and NIH grant EY-12951 (J.R.S.).

Ben‐Shabat, S., Itagaki, Y., Steffen Jockusch, B., Sparrow, J. R., Turro, N. J., & Nakanishi, K. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020301)41:5 · Cited by 207 · see citing works

Allelic variation in ABCR associated with Stargardt disease but not age-related macular degeneration

Stone, E. M., Webster, A. R., Vandenburgh, K., Streb, L. M., Hockey, R. R., Lotery, A. J., & Sheffield, V. C. (1998) · Nature Genetics · doi:10.1038/3798 · Cited by 197 · see citing works

Fundus autofluorescence in patients with age-related macular degeneration and high risk of visual loss

Lois, N., Owens, S. L., Coco, R. M., Hopkins, J. J., Fitzke, F. W., & Bird, A. C. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)01404-0 · Cited by 181 · see citing works

N-Retinylidene-phosphatidylethanolamine Is the Preferred Retinoid Substrate for the Photoreceptor-specific ABC Transporter ABCA4 (ABCR)

Beharry, S., Zhong, M., & Molday, R. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405216200 · Cited by 174 · see citing works

The photoreceptor rim protein is an ABC transporter encoded by the gene for recessive Stargardt's disease (ABCR)

Azarian, S. M., & Travis, G. H. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00517-6 · Cited by 170 · see citing works

Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration

Radu, R. A., Mata, N. L., Bagla, A., & Travis, G. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308302101 · Cited by 167 · see citing works

Inhibition of the visual cycle in vivo by 13 -cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy

Sieving, P. A., Chaudhry, P. S., Kondo, M., Provenzano, M. J., Wu, D. M., Carlson, T. J., Bush, R. A., & Thompson, D. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1835 · Cited by 152 · see citing works

Light adaptation of human rod receptors: the leading edge of the human a-wave and models of rod receptor activity

Hood, D. C., & Birch, D. G. (1993) · Vision Research · doi:10.1016/0042-6989(93)90027-t · Cited by 148 · see citing works

Isolation and characterization of a retinal pigment epithelial cell fluorophore: An <i>all-trans</i> -retinal dimer conjugate

Fishkin, N. E., Sparrow, J. R., Allikmets, R., & Nakanishi, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501266102 · Cited by 146 · see citing works

The <i>all-trans</i> -retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model

Kim, S. R., Jang, Y. P., Jockusch, S., Fishkin, N. E., Turro, N. J., & Sparrow, J. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708714104 · Cited by 145 · see citing works

Opsin/all-trans-Retinal Complex Activates Transducin by Different Mechanisms Than Photolyzed Rhodopsin

Jäger, S., Palczewski, K., & Hofmann, K. P. (1996) · Biochemistry · doi:10.1021/bi9524068 · Cited by 138 · see citing works

The spectrum of retinal phenotypes caused by mutations in the ABCA4 gene

Klevering, B. J., Deutman, A. F., Maugeri, A., Cremers, F. P. M., & Hoyng, C. B. (2004) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-004-1079-4 · Cited by 125 · see citing works

Microarray-based mutation analysis of the ABCA4 (ABCR) gene in autosomal recessive cone–rod dystrophy and retinitis pigmentosa

Klevering, B. J., Yzer, S., Rohrschneider, K., Zonneveld, M. N., Allikmets, R. L., van den Born, L. I., Maugeri, A., Hoyng, C. B., & Cremers, F. P. M. (2004) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201258 · Cited by 110 · see citing works

In vitro interaction of fenretinide with plasma retinol‐binding protein and its functional consequences

Berni, R., & Formelli, F. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81046-o · Cited by 105 · see citing works

Interaction of A2E with Model Membranes. Implications to the Pathogenesis of Age-related Macular Degeneration

De, S., & Sakmar, T. P. (2002) · The Journal of General Physiology · doi:10.1085/jgp.20028566 · Cited by 91 · see citing works

Delayed Rod Dark Adaptation in Patients with Stargardt's Disease

Fishman, G. A., Farbman, J. S., & Alexander, K. R. (1991) · Ophthalmology · doi:10.1016/s0161-6420(91)32196-1 · Cited by 86 · see citing works

Retinol-Binding Protein-Deficient Mice: Biochemical Basis for Impaired Vision

Vogel, S., Piantedosi, R., O’Byrne, S. M., Kako, Y., Quadro, L., Gottesman, M. E., Goldberg, I. J., & Blaner, W. S. (2002) · Biochemistry · doi:10.1021/bi0268551 · Cited by 86 · see citing works

Changes in fundus autofluorescence in patients with age-related maculopathy. Correlation to visual function: a prospective study

Einbock, W., Moessner, A., Schnurrbusch, U., Holz, F. G., Wolf, S., & for the FAM Study Group (2004) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-004-1027-3 · Cited by 83 · see citing works

Fundus autofluorescence in children and teenagers with hereditary retinal diseases

Wabbels, B., Demmler, A., Paunescu, K., Wegscheider, E., Preising, M. N., & Lorenz, B. (2005) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-005-0043-2 · Cited by 71 · see citing works

Photophysical Studies of A2-E, Putative Precursor of Lipofuscin, in Human Retinal Pigment Epithelial Cells

Cubeddu, R., Taroni, P., Hu, D., Sakai, N., Nakanishi, K., & Roberts, J. E. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb07986.x · Cited by 51 · see citing works

Characterization of Native Retinal Fluorophores Involved in Biosynthesis of A2E and Lipofuscin-associated Retinopathies

Bui, T. V., Han, Y., Radu, R. A., Travis, G. H., & Mata, N. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601380200 · Cited by 48 · see citing works

Electroretinographic evidence for altered phototransduction gain and slowed recovery from photobleaches in albino mice with a MET450 variant in RPE65

Nusinowitz, S., Nguyen, L., Radu, R. A., Kashani, Z., Farber, D. B., & Danciger, M. (2003) · Experimental Eye Research · doi:10.1016/s0014-4835(03)00217-3 · Cited by 48 · see citing works

The molecular basis of retinoic acid induced night blindness

Law, W. C., & Rando, R. R. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92674-0 · Cited by 48 · see citing works

Partial Agonism in a G Protein-coupled Receptor

Bartl, F. J., Fritze, O., Ritter, E., Herrmann, R., Kuksa, V., Palczewski, K., Hofmann, K. P., & Ernst, O. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505260200 · Cited by 44 · see citing works

Lipofuscin in the Retina: Quantitative Assay for an Unprecedented Autofluorescent Compound (Pyridinium Bis-Retinoid, A2-E) of Ocular Age Pigment

Reinboth, J., Gautschi, K., Munz, K., Eldred, G. E., & Remé, C. E. (1997) · Experimental Eye Research · doi:10.1006/exer.1997.0367 · Cited by 38 · see citing works

Substrate specificities and 13-cis-retinoic acid inhibition of human, mouse and bovine cis-retinol dehydrogenases

Gamble, M. V., Mata, N. L., Tsin, A. T., Mertz, J. R., & Blaner, W. S. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(99)00232-0 · Cited by 34 · see citing works

Characterization of Dihydro-A2PE: An Intermediate in the A2E Biosynthetic Pathway

Kim, S. R., He, J., Yanase, E., Jang, Y. P., Berova, N. D., Sparrow, J. R., & Nakanishi, K. (2007) · Biochemistry · doi:10.1021/bi7009635 · Cited by 32 · see citing works

Indocyanine Green Angiography in Fundus flavimaculatus

Schwoerer, J., Secrétan, M., Zografos, L., & Piguet, B. (2000) · Ophthalmologica · doi:10.1159/000027498 · Cited by 20 · see citing works

The Retinal Pigment Epithelium in Health and Disease

Sparrrow, J. R., Hicks, D., & Hamel, C. (2010) · Current Molecular Medicine · doi:10.2174/156652410793937813 · Cited by 625 · see citing works

The bisretinoids of retinal pigment epithelium

Sparrow, J. R., Gregory-Roberts, E., Yamamoto, K., Blonska, A., Ghosh, S. K., Ueda, K., & Zhou, J. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.12.001 · Cited by 392 · see citing works

Stargardt disease: clinical features, molecular genetics, animal models and therapeutic options

Tanna, P., Strauss, R. W., Fujinami, K., & Michaelides, M. (2016) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2016-308823 · Cited by 371 · see citing works

Effective delivery of large genes to the retina by dual AAV vectors

Trapani, I., Colella, P., Sommella, A., Iodice, C., Cesi, G., de Simone, S., Marrocco, E., Rossi, S., Giunti, M., Palfi, A., et al. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201302948 · Cited by 269 · see citing works

Clinical and Genetic Characteristics of Late-onset Stargardt's Disease

Haaften, S. C. W.-V., Boon, C. J. F., Cremers, F. P. M., Hoefsloot, L. H., den Hollander, A. I., & Hoyng, C. B. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2012.01.005 · Cited by 203 · see citing works

Phospholipid meets all-trans-retinal: the making of RPE bisretinoids

Sparrow, J. R., Wu, Y., Kim, C. Y., & Zhou, J. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r000687 · Cited by 193 · see citing works

Molecular basis for photoreceptor outer segment architecture

Goldberg, A. F. X., Moritz, O. L., & Williams, D. S. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.05.003 · Cited by 180 · see citing works

Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration

Lenis, T. L., Hu, J., Ng, S. Y., Jiang, Z., Sarfare, S., Lloyd, M. B., Esposito, N. J., Samuel, W., Jaworski, C., Bok, D., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802519115 · Cited by 158 · see citing works

Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for stargardt macular degeneration

Radu, R. A., Hu, J., Yuan, Q., Welch, D. L., Makshanoff, J., Lloyd, M., McMullen, S., Travis, G. H., & Bok, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.191866 · Cited by 157 · see citing works

Functional roles of bestrophins in ocular epithelia

Marmorstein, A. D., Cross, H. E., & Peachey, N. S. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.04.004 · Cited by 134 · see citing works

Fundus Autofluorescence in the Abca4 −/− Mouse Model of Stargardt Disease—Correlation With Accumulation of A2E, Retinal Function, and Histology

Issa, P. C., Barnard, A. R., Singh, M. S., Carter, E., Jiang, Z., Radu, R. A., Schraermeyer, U., & MacLaren, R. E. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-11688 · Cited by 128 · see citing works

Rescue of the Stargardt phenotype in <i>Abca4</i> knockout mice through inhibition of vitamin A dimerization

Charbel Issa, P., Barnard, A. R., Herrmann, P., Washington, I., & MacLaren, R. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506960112 · Cited by 124 · see citing works

Retinitis Pigmentosa: Current Clinical Management and Emerging Therapies

Nguyen, X., Moekotte, L., Plomp, A. S., Bergen, A. A. B., van Genderen, M. M., & Boon, C. J. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087481 · Cited by 135 · see citing works

Phagocytosis-dependent ketogenesis in retinal pigment epithelium

Reyes-Reveles, J., Dhingra, A., Alexander, D., Bragin, A., Philp, N. J., & Boesze-Battaglia, K. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.770784 · Cited by 116 · see citing works

Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration

Ueda, K., Zhao, J., Kim, H. J., & Sparrow, J. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524774113 · Cited by 115 · see citing works

The role of interphotoreceptor retinoid-binding protein on the translocation of visual retinoids and function of cone photoreceptors

Jin, M., Li, S., Nusinowitz, S., Lloyd, M., Hu, J., Radu, R. A., Bok, D., & Travis, G. H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3882-08.2009 · Cited by 109 · see citing works

Retinoids for treatment of retinal diseases

Palczewski, K. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.03.001 · Cited by 111 · see citing works

The Role of Vitamin A in Retinal Diseases

Sajovic, J., Meglič, A., Glavač, D., Markelj, Š., Hawlina, M., & Fakin, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031014 · Cited by 109 · see citing works

G1961E mutant allele in the Stargardt disease gene ABCA4 causes bull's eye maculopathy

Cella, W., Greenstein, V. C., Zernant, J., Smith, T. R., Barile, G. R., Allikmets, R. L., & Tsang, S. H. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.02.001 · Cited by 108 · see citing works

Structure and function of ABCA4 and its role in the visual cycle and Stargardt macular degeneration

Molday, R. S., Garces, F. A., Scortecci, J. F., & Molday, L. L. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.101036 · Cited by 107 · see citing works

Macular dystrophies mimicking age-related macular degeneration

Saksens, N. T. M., Fleckenstein, M., Schmitz-Valckenberg, S., Holz, F. G., den Hollander, A. I., KEUNEN, J. E. E., Boon, C. J. F., & Hoyng, C. B. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.11.001 · Cited by 102 · see citing works

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Collin, G. B., Gogna, N., Chang, B., Damkham, N., Pinkney, J., Hyde, L. F., Stone, L. V., Naggert, J. Κ., Nishina, P. M., & Krebs, M. P. (2020) · Cells · doi:10.3390/cells9040931 · Cited by 94 · see citing works

Progression of Retinal Pigment Epithelial Atrophy in Stargardt Disease

McBain, V. A., Townend, J., & Lois, N. (2012) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2012.01.019 · Cited by 93 · see citing works

An AAV Dual Vector Strategy Ameliorates the Stargardt Phenotype in Adult <i> Abca4 ^−/− </i> Mice

McClements, M. E., Barnard, A. R., Singh, M. S., Charbel Issa, P., Jiang, Z., Radu, R. A., & MacLaren, R. E. (2019) · Human Gene Therapy · doi:10.1089/hum.2018.156 · Cited by 92 · see citing works

Retinal Phenotypes in Patients Homozygous for the G1961E Mutation in the ABCA4 Gene

Burke, T. R., Fishman, G. A., Zernant, J., Schubert, C., Tsang, S. H., Smith, R. T., Ayyagari, R., Koenekoop, R. K., Umfress, A. C., Ciccarelli, M. L., et al. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-9166 · Cited by 92 · see citing works

Fundus Autofluorescence and RPE Lipofuscin in Age-Related Macular Degeneration

Sparrow, J. R., & Duncker, T. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3041302 · Cited by 89 · see citing works

Progression of Stargardt Disease as Determined by Fundus Autofluorescence Over a 12-Month Period

Strauss, R. W., Kong, X., Ho, A., Jha, A., West, S. K., Ip, M. S., Bernstein, P. S., Birch, D. G., Cideciyan, A. V., Michaelides, M., et al. (2019) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2019.2885 · Cited by 86 · see citing works

Differential expression and function of ABCG1 and ABCG4 during development and aging

Bojanic, D. D., Tarr, P. T., Gale, G. D., Smith, D. J., Bok, D., Chen, B., Nusinowitz, S., Lövgren‐Sandblom, A., Björkhem, I., & Edwards, P. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900250-jlr200 · Cited by 84 · see citing works

Defective lipid transport and biosynthesis in recessive and dominant Stargardt macular degeneration

Molday, R. S., & Zhang, K. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.07.002 · Cited by 82 · see citing works

Deuterium Enrichment of Vitamin A at the C20 Position Slows the Formation of Detrimental Vitamin A Dimers in Wild-type Rodents

Kaufman, Y., Ma, L., & Washington, I. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.178640 · Cited by 78 · see citing works

Quantitative Fundus Autofluorescence in Mice: Correlation With HPLC Quantitation of RPE Lipofuscin and Measurement of Retina Outer Nuclear Layer Thickness

Sparrow, J. R., Blonska, A. M., Flynn, E., Duncker, T., Greenberg, J. P., Secondi, R., Ueda, K., & Delori, F. C. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-11490 · Cited by 77 · see citing works

Using the rd1 mouse to understand functional and anatomical retinal remodelling and treatment implications in retinitis pigmentosa: A review

Kalloniatis, M., Nivison‐Smith, L., Chua, J., Acosta, M. L., & Fletcher, E. L. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.10.019 · Cited by 77 · see citing works

Photoreceptor Cell Degeneration in Abcr –/– Mice

Wu, L., Nagasaki, T., & Sparrow, J. R. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-1399-9_61 · Cited by 77 · see citing works

Foveal Sparing in Stargardt Disease

van Huet, R. A. C., Bax, N. M., Haaften, S. C. W.-V., Muhamad, M., Zonneveld-Vrieling, M. N., Hoefsloot, L. H., Cremers, F. P. M., Boon, C. J. F., Klevering, B. J., & Hoyng, C. B. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13825 · Cited by 74 · see citing works

Efficacy and Safety of Saffron Supplementation: Current Clinical Findings

Broadhead, G., Chang, A., Grigg, J., & McCluskey, P. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.879467 · Cited by 72 · see citing works

Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease

Lenis, T. L., Sarfare, S. S., Jiang, Z., Lloyd, M. B., Bok, D., & Radu, R. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620299114 · Cited by 72 · see citing works

Treatments for dry age-related macular degeneration and Stargardt disease: a systematic review

Waugh, N. R., Loveman, E., Colquitt, J. L., Royle, P., Yeong, J. L., Hoad, G. V., & Lois, N. (2018) · Health Technology Assessment · doi:10.3310/hta22270 · Cited by 70 · see citing works

An Overview of the Genetics of ABCA4 Retinopathies, an Evolving Story

Al‐Khuzaei, S., Broadgate, S., Foster, C. R., Shah, M., Yu, J., Downes, S. M., & Halford, S. (2021) · Genes · doi:10.3390/genes12081241 · Cited by 73 · see citing works

Nonsyndromic Retinitis Pigmentosa Overview

Fahim, A. T., Daiger, S. P., & Weleber, R. G. (2017) · Europe PMC (PubMed Central) · Cited by 70 · see citing works

A CTRP5 gene S163R mutation knock-in mouse model for late-onset retinal degeneration

Chavali, V. R. M., Khan, N. W., Cukras, C. A., Bartsch, D., Jablonski, M. M., & Ayyagari, R. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr080 · Cited by 67 · see citing works

Iron promotes oxidative cell death caused by bisretinoids of retina

Ueda, K., Kim, H. J., Zhao, J., Song, Y., Dunaief, J. L., & Sparrow, J. R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722601115 · Cited by 65 · see citing works

Oxidative stress: The achilles' heel of neurodegenerative diseases of the retina

Cai, X. (2011) · Frontiers in bioscience · doi:10.2741/4033 · Cited by 62 · see citing works

Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium

Nociari, M., Lehmann, G. L., Bay, A. E. P., Radu, R. A., Jiang, Z., Goicochea, S., Schreiner, R. P., Warren, J. D., Shan, J., de Beaumais, S. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400530111 · Cited by 61 · see citing works

Lipofuscin, Its Origin, Properties, and Contribution to Retinal Fluorescence as a Potential Biomarker of Oxidative Damage to the Retina

Rôżanowska, M. (2023) · Antioxidants · doi:10.3390/antiox12122111 · Cited by 59 · see citing works

Botanical Compounds: Effects on Major Eye Diseases

Huynh, T.-P., Mann, S. N., & Mandal, N. A. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/549174 · Cited by 56 · see citing works

Dual <i>ABCA4</i> -AAV Vector Treatment Reduces Pathogenic Retinal A2E Accumulation in a Mouse Model of Autosomal Recessive Stargardt Disease

Dyka, F. M., Molday, L. L., Chiodo, V. A., Molday, R. S., & Hauswirth, W. W. (2019) · Human Gene Therapy · doi:10.1089/hum.2019.132 · Cited by 56 · see citing works

Stargardt disease and progress in therapeutic strategies

Huang, D., Jeffery, R. C. H., Aung-Htut, M. T., McLenachan, S., Fletcher, S., Wilton, S. D., & Chen, F. K. (2021) · Ophthalmic Genetics · doi:10.1080/13816810.2021.1966053 · Cited by 56 · see citing works

Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles

Sun, D., Schur, R. M., Sears, A. E., Gao, S., Vaidya, A. M., Sun, W., Maeda, A., Kern, T. S., Palczewski, K., & Lu, Z. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.09.010 · Cited by 56 · see citing works

All-Trans Retinoic Acid Modulates DNA Damage Response and the Expression of the VEGF-A and MKI67 Genes in ARPE-19 Cells Subjected to Oxidative Stress

Tokarz, P., Piastowska‐Ciesielska, A. W., Kaarniranta, K., & Błasiak, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060898 · Cited by 53 · see citing works

Recent Advances of Stem Cell Therapy for Retinitis Pigmentosa

He, Y., Zhang, Y., Liu, X., Ghazaryan, E., Li, Y., Xie, J., & Su, G. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150814456 · Cited by 51 · see citing works

Ultrastructural alterations in the retinal pigment epithelium and photoreceptors of a Stargardt patient and three Stargardt mouse models: indication for the central role of RPE melanin in oxidative stress

Taubitz, T., Tschulakow, A., Валерьевна, Т. М., Illing, B., Fang, Y., Biesemeier, A., Julien, S., & Schraermeyer, U. (2018) · PeerJ · doi:10.7717/peerj.5215 · Cited by 51 · see citing works

Pathways and disease-causing alterations in visual chromophore production for vertebrate vision

Kiser, P. D., & Palczewski, K. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.014405 · Cited by 49 · see citing works

Therapy Approaches for Stargardt Disease

Piotter, E., McClements, M. E., & MacLaren, R. E. (2021) · Biomolecules · doi:10.3390/biom11081179 · Cited by 49 · see citing works

Light Damage in Abca4 and Rpe65 rd12 Mice

Wu, L., Ueda, K., Nagasaki, T., & Sparrow, J. R. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-13867 · Cited by 48 · see citing works

Retinitis Pigmentosa Overview

Fahim, A. T., Daiger, S. P., & Weleber, R. G. (2013) · Cited by 48 · see citing works

Clinical Phenotypes and Prognostic Full-Field Electroretinographic Findings in Stargardt Disease

Zahid, S., Jayasundera, T., Rhoades, W. R., Branham, K. E. H., Khan, N., Niziol, L. M., Musch, D. C., & Heckenlively, J. R. (2012) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2012.09.011 · Cited by 47 · see citing works

Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy)

Graßmann, F., Bergholz, R., Mändl, J., Jägle, H., Rüether, K., & Weber, B. H. F. (2015) · BMC Ophthalmology · doi:10.1186/s12886-015-0008-0 · Cited by 47 · see citing works

Predicting Progression of ABCA4 -Associated Retinal Degenerations Based on Longitudinal Measurements of the Leading Disease Front

Cideciyan, A. V., Świder, M., Schwartz, S., Stone, E. M., & Jacobson, S. G. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17698 · Cited by 47 · see citing works

Evaluation of Potential Therapies for a Mouse Model of Human Age-Related Macular Degeneration Caused by Delayed all- trans -Retinal Clearance

Maeda, T., Maeda, A., Matosky, M., Okano, K., Roos, S. S., Tang, J. C. O., & Palczewski, K. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3581 · Cited by 47 · see citing works

Membrane receptors and transporters involved in the function and transport of vitamin A and its derivatives

Sun, H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.06.010 · Cited by 46 · see citing works

Clinical and Rehabilitative Management of Retinitis Pigmentosa:Up-to-Date

Nadai, K. D., Romano, M., Binotto, A., Costagliola, C., Sato, G., & Parmeggiani, F. (2011) · Current Genomics · doi:10.2174/138920211795860125 · Cited by 46 · see citing works

Bisretinoid phospholipid and vitamin A aldehyde: shining a light

Kim, H. J., & Sparrow, J. R. (2020) · Journal of Lipid Research · doi:10.1194/jlr.tr120000742 · Cited by 46 · see citing works

Effects of deficiency in the RLBP1-encoded visual cycle protein CRALBP on visual dysfunction in humans and mice

Lima de Carvalho, J. R., Kim, H. J., Ueda, K., Zhao, J., Owji, A. P., Yang, T., Tsang, S. H., & Sparrow, J. R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.012695 · Cited by 42 · see citing works

Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype

Radu, R. A., Hu, J., Jiang, Z., & Bok, D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.548669 · Cited by 44 · see citing works

Retinal Photodamage by Endogenous and Xenobiotic Agents†

Wielgus, A. R., & Roberts, J. E. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01174.x · Cited by 43 · see citing works

Gene Therapy of ABCA4-Associated DiseasesPreprint

Auricchio, A., Trapani, I., & Allikmets, R. L. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a017301 · Cited by 41 · see citing works

Vitamin A-aldehyde adducts: AMD risk and targeted therapeutics

Sparrow, J. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600474113 · Cited by 39 · see citing works

Next-generation sequencing of ABCA4: High frequency of complex alleles and novel mutations in patients with retinal dystrophies from Central Europe

Ścieżyńska, A., Oziębło, D., Ambroziak, A. M., Korwin, M., Szulborski, K., Krawczynski, M. R., Stawiński, P., Szaflik, J., Szaflik, J. P., Płoski, R., et al. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.11.011 · Cited by 36 · see citing works

Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition

Zhou, J., Ueda, K., Zhao, J., & Sparrow, J. R. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.680363 · Cited by 34 · see citing works

Vitamins and Mineral Supplements for Retinitis Pigmentosa

Zhao, Y., Feng, K., Liu, R., Pan, J.-H., Zhang, L.-L., & Lu, X. (2019) · Journal of Ophthalmology · doi:10.1155/2019/8524607 · Cited by 34 · see citing works

Progression of Stargardt Disease as Determined by Fundus Autofluorescence Over a 24-Month Period (ProgStar Report No. 17)

Strauss, R. W., Ho, A., Jha, A., Fujinami, K., Michaelides, M., Cideciyan, A. V., Audo, I. S., Birch, D. G., Sadda, S. R., Ip, M. S., et al. (2023) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2023.02.003 · Cited by 31 · see citing works

Vitamin A

Ross, A., & Harrison, E. H. (2013) · CRC Press eBooks · doi:10.1201/b15413-2 · Cited by 30 · see citing works

Nutraceutical Supplementation Ameliorates Visual Function, Retinal Degeneration, and Redox Status in rd10 Mice

Olivares‐González, L., Velasco, S., Campillo, I., Salom, D., García, E. G., Soriano, J. M., & Rodrigo, R. (2021) · Antioxidants · doi:10.3390/antiox10071033 · Cited by 30 · see citing works

The cost of genetic testing for ocular disease

Capasso, J. E. (2014) · Current Opinion in Ophthalmology · doi:10.1097/icu.0000000000000085 · Cited by 29 · see citing works

Diagnosis of Inherited Retinal Diseases

Birtel, J., Yusuf, I. H., Priglinger, C., Rudolph, G., & Issa, P. C. (2021) · Klinische Monatsblätter für Augenheilkunde · doi:10.1055/a-1388-7236 · Cited by 28 · see citing works

Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration

Ng, E. S. Y., Kady, N., Hu, J. G., Dave, A. R., Jiang, Z., Pei, J., Gorin, M. B., Matynia, A., & Radu, R. A. (2022) · Cells · doi:10.3390/cells11213462 · Cited by 28 · see citing works

Understanding RPE Lipofuscin

Sparrow, J. R., Dowling, J. E., & Bok, D. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13214 · Cited by 28 · see citing works

Emerging Therapeutic Approaches and Genetic Insights in Stargardt Disease: A Comprehensive Review

Ghenciu, L. A., Hațegan, O. A., Stoicescu, E. R., Iacob, R., & Șișu, A. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168859 · Cited by 29 · see citing works

Stargardt macular dystrophy: common ABCA4 mutations in South Africa--establishment of a rapid genetic test and relating risk to patients.

Roberts, L. J., Nossek, C., Greenberg, L. S., & Ramesar, R. (2012) · Europe PMC (PubMed Central) · Cited by 26 · see citing works

Effectiveness and safety of nutritional supplements in the treatment of hereditary retinal dystrophies: a systematic review

Brito-García, N., del Pino-Sedeño, T., Trujillo-Martín, M. M., Coco, R. M., Rodríguez de la Rúa, E., del Cura-González, I., & Serrano-Aguilar, P. (2017) · Eye · doi:10.1038/eye.2016.286 · Cited by 26 · see citing works

Dietary profile of patients with Stargardt’s disease and Retinitis Pigmentosa: is there a role for a nutritional approach?

Sofi, F., Sodi, A., Franco, F., Murro, V., Biagini, D., Miele, A., Abbruzzese, G., Mucciolo, D. P., Virgili, G., Menchini, U., et al. (2016) · BMC Ophthalmology · doi:10.1186/s12886-016-0187-3 · Cited by 24 · see citing works

Vitamin A, systemic T-cells, and the eye: Focus on degenerative retinal disease

Thirunavukarasu, A. J., Ross, A. C., & Gilbert, R. M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.914457 · Cited by 26 · see citing works

The lipid translocase, ABCA4: seeing is believing

Pollock, N. L., & Callaghan, R. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2011.08169.x · Cited by 22 · see citing works

Vitamin A in Stargardt disease—an evidence-based update

Federspiel, C. A., Bertelsen, M., & Kessel, L. (2018) · Ophthalmic Genetics · doi:10.1080/13816810.2018.1488174 · Cited by 23 · see citing works

A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration

Shin, Y., Moiseyev, G. P., Petrukhin, K. E., Cioffi, C. L., Muthuraman, P., Takahashi, Y., & Ma, J. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.04.014 · Cited by 21 · see citing works

Monitoring and Management of the Patient with Stargardt Disease

Cicinelli, M. V., Battista, M., Starace, V., Parodi, M. B., & Bandello, F. M. (2019) · Clinical Optometry · doi:10.2147/opto.s226595 · Cited by 21 · see citing works

Progress toward effective treatments for human photoreceptor degenerations

Stone, E. M. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.03.006 · Cited by 19 · see citing works

Cytochrome P450 2C Epoxygenases Mediate Photochemical Stress-induced Death of Photoreceptors

Chang, Q., Berdyshev, E. V., Cao, D., Bogaard, J. D., White, J. J., Chen, S., Shah, R., Mu, W., Grantner, R., Bettis, S., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.507152 · Cited by 18 · see citing works

Analysis of mitochondrial dynamics and function in the retinal pigment epithelium by high-speed high-resolution live imaging

Tan, L. X., Li, J., Germer, C. J., & Lakkaraju, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1044672 · Cited by 17 · see citing works

Historical evolution in the understanding of Stargardt macular dystrophy

Fishman, G. A. (2010) · Ophthalmic Genetics · doi:10.3109/13816810.2010.499887 · Cited by 17 · see citing works

Updates on Emerging Interventions for Autosomal Recessive ABCA4-Associated Stargardt Disease

Wang, L., Shah, S. M., Mangwani‐Mordani, S., & Gregori, N. Z. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12196229 · Cited by 19 · see citing works

Bisretinoid Photodegradation Is Likely Not a Good Thing

Ueda, K., Kim, H. J., Zhao, J., & Sparrow, J. R. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-75402-4_49 · Cited by 16 · see citing works

Mice Lacking the Systemic Vitamin A Receptor RBPR2 Show Decreased Ocular Retinoids and Loss of Visual Function

Radhakrishnan, R., Leung, M., Roehrich, H., Walterhouse, S. H., Kondkar, A. A., Fitzgibbon, W. R., Biswal, M. R., & Lobo, G. P. (2022) · Nutrients · doi:10.3390/nu14122371 · Cited by 17 · see citing works

Diacylglycerol O-Acyltransferase Type-1 Synthesizes Retinyl Esters in the Retina and Retinal Pigment Epithelium

Kaylor, J. J., Radu, R. A., Bischoff, N., Makshanoff, J., Hu, J. G., Lloyd, M. B., Eddington, S., Bianconi, T., Bok, D., & Travis, G. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125921 · Cited by 16 · see citing works

Advances and therapeutic opportunities in visual cycle modulation

Zaluski, J., Bassetto, M., Kiser, P. D., & Tochtrop, G. P. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101360 · Cited by 15 · see citing works

En face OCT in Stargardt disease

Sodi, A., Mucciolo, D. P., Cipollini, F., Murro, V., Caporossi, O., Virgili, G., & Rizzo, S. (2016) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-015-3254-1 · Cited by 15 · see citing works

VITAMIN A DEFICIENCY MONITORED BY QUANTITATIVE SHORT WAVELENGTH FUNDUS AUTOFLUORESCENCE IN A CASE OF BARIATRIC SURGERY

Lima de Carvalho, J. R., Tsang, S. H., & Sparrow, J. R. (2022) · RETINAL Cases &amp; Brief Reports · doi:10.1097/icb.0000000000000931 · Cited by 14 · see citing works

Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28

Moran, A. L., Carter, S. P., Kaylor, J. J., Jiang, Z., Broekman, S., Dillon, E., Sánchez, A. G., Minhas, S. K., van Wijk, E., Radu, R. A., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101897r · Cited by 14 · see citing works

Providing comprehensive genetic-based ophthalmic care

Branham, K. E. H., & Yashar, B. M. (2013) · Clinical Genetics · doi:10.1111/cge.12192 · Cited by 14 · see citing works

A Novel Neuroprotective Small Molecule for Glial Cell Derived Neurotrophic Factor Induction and Photoreceptor Rescue

Baranov, P. Y., Lin, H., McCabe, K. L., Gale, D. C., Cai, S., Lieppman, B., Morrow, D. M., Lei, P., Liao, J., & Young, M. J. (2017) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2016.0121 · Cited by 14 · see citing works

Rescue of the Stargardt Disease Phenotype in Abca4 Knockout Mice Through Dietary Modulation of the Vitamin A Receptor RBPR2

Radhakrishnan, R., Leung, M., Yochim, D., Roehrich, H., McPherson, S. W., & Lobo, G. P. (2025) · FASEB BioAdvances · doi:10.1096/fba.2025-00173 · Cited by 2 · see citing works

Reductions in Serum Vitamin A Arrest Accumulation of Toxic Retinal Fluorophores: A Potential Therapy for Treatment of Lipofuscin-Based Retinal Diseases

Radu, R. A., Han, Y., Bui, T. V., Nusinowitz, S., Bok, D., Lichter, J. B., Widder, K., Travis, G. H., & Mata, N. L. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0820 · Cited by 225 · see citing works

Rescue of the Stargardt phenotype in <i>Abca4</i> knockout mice through inhibition of vitamin A dimerization

Charbel Issa, P., Barnard, A. R., Herrmann, P., Washington, I., & MacLaren, R. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506960112 · Cited by 124 · see citing works

C20-D3-vitamin A Slows Lipofuscin Accumulation and Electrophysiological Retinal Degeneration in a Mouse Model of Stargardt Disease

Ma, L., Kaufman, Y., Zhang, J., & Washington, I. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.178657 · Cited by 83 · see citing works

Sequence of lipofuscin accumulation, retinoid cycle slowing and retinal degeneration in human ABCA4 disease

Cideciyan, A. V., Alemán, T. S., Świder, M., Schwartz, S., Steinberg, J. D., Brucker, A. J., Maguire, A. M., Bennett, J., Stone, E. M., & Jacobson, S. (2004) · Investigative Ophthalmology & Visual Science