The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Relationship between RPE and Choriocapillaris in Age-Related Macular Degeneration
Open accessAbstract
PURPOSE: The purpose of this study was to examine the relationships between choriocapillaris (CC) and retinal pigment epithelial changes in age-related macular degeneration (AMD). Morphologic changes in the retinal pigment epithelium (RPE)/choriocapillaris complex were quantified in dry and wet forms of AMD, and the results were compared with those in aged control eyes without maculopathy. METHODS: Postmortem choroids from three aged control subjects, five subjects with geographic atrophy (GA), and three subjects with wet AMD were analyzed using a semiquantitative computer-assisted morphometric technique developed to measure the percentages of retinal pigment epithelial and CC areas in choroidal wholemounts incubated for alkaline phosphatase activity. The tissues were subsequently embedded in methacrylate and were sectioned so that structural changes could be examined. RESULTS: There was a linear relationship between the loss of RPE and CC in GA. A 50% reduction in vascular area was found in regions of complete retinal pigment epithelial atrophy. Extreme constriction of remaining viable capillaries was found in areas devoid of RPE. Adjacent to active choroidal neovascularization (CNV) in wet AMD, CC dropout was evident in the absence of retinal pigment epithelial atrophy, resulting in a 50% decrease in vascular area. Lumenal diameters of the remaining capillaries in wet AMD eyes were similar to those in control eyes. CONCLUSIONS: The primary insult in GA appears to be at the level of the RPE, and there is an intimate relationship between retinal pigment epithelial atrophy and secondary CC degeneration. CC degeneration occurs in the presence of viable RPE in wet AMD. The RPE in regions of vascular dropout are presumably hypoxic, which may result in an increase in VEGF production by the RPE and stimulation of CNV.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
Beatty, S., Koh, H.-H., Phil, M., Henson, D., & Boulton, M. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00140-5 · Cited by 2,051
Alon, T., Hemo, I., Itin, A., Pe'er, J., Stone, J., & Keshet, E. (1995) · Nature Medicine · doi:10.1038/nm1095-1024 · Cited by 1,604
Roberts, W. G., & Palade, G. E. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.6.2369 · Cited by 1,033
Stereoscopic Atlas of Macular Diseases: Diagnosis and Treatment
(1990) · Archives of Ophthalmology · doi:10.1001/archopht.1990.01070060042026 · Cited by 1,009
Evolution of geographic atrophy of the retinal pigment epithelium
Sarks, J. P., Sarks, S. H., & Killingsworth, M. C. (1988) · Eye · doi:10.1038/eye.1988.106 · Cited by 804
Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging.
Ramrattan, R. S., van der Schaft, T. L., Mooy, C. M., de Bruijn, W. C., Mulder, P. G. H., & de Jong, P. T. (1994) · PubMed · Cited by 744
Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro
Esser, S., Wolburg, K., Wolburg, H., Breier, G., Kurzchalia, T., & Risau, W. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.4.947 · Cited by 648
Oxidative damage and protection of the RPE
Cai, J., Nelson, K. C., Wu, M., Sternberg, P., & Jones, D. P. (2000) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(99)00009-9 · Cited by 628
Stereoscopic atlas of macular diseases
Gass, J. D. M. (1977) · Cited by 576
Cited by
Age-related macular degeneration
Mitchell, P., Liew, G., Gopinath, B., & Wong, T. Y. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31550-2 · Cited by 1,511
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88
Tarallo, V., Hirano, Y., Gelfand, B. D., Dridi, S., Kerur, N., Kim, Y., Cho, W. G., Kaneko, H., Fowler, B. J., Bogdanovich, S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.036 · Cited by 592
Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials
Grunwald, J. E., Daniel, E., Huang, J., Ying, G.-S., Maguire, M. G., Toth, C. A., Jaffe, G. J., Fine, S. L., Blodi, B., Klein, M. L., et al. (2014) · Ophthalmology · doi:10.1016/j.ophtha.2013.08.015 · Cited by 590
Optical coherence tomography: Imaging of the choroid and beyond
Mrejen, S., & Spaide, R. F. (2013) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2012.12.001 · Cited by 477
A paradigm shift in imaging biomarkers in neovascular age-related macular degeneration
Schmidt-Erfurth, U., & Waldstein, S. M. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.007 · Cited by 390
EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration
Shu, D. Y., Butcher, E., & Saint-Geniez, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124271 · Cited by 292
Choriocapillaris breakdown precedes retinal degeneration in age-related macular degeneration
Biesemeier, A., Taubitz, T., Julien, S., Yoeruek, E., & Schraermeyer, U. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.05.003 · Cited by 287
Grunwald, J. E., Pistilli, M., Daniel, E., Ying, G.-S., Pan, W., Jaffe, G. J., Toth, C. A., Hagstrom, S. A., Maguire, M. G., & Martin, D. F. (2017) · Ophthalmology · doi:10.1016/j.ophtha.2016.09.012 · Cited by 214
On phagocytes and macular degeneration
Guillonneau, X., Eandi, C. M., Paques, M., Sahel, J.-A., Sapieha, P., & Sennlaub, F. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.06.002 · Cited by 185
Senescence in the pathogenesis of age-related macular degeneration
Blasiak, J. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03420-x · Cited by 183
Sura, A. A., Chen, L., Messinger, J. D., Swain, T. A., McGwin, G., Freund, K. B., & Curcio, C. A. (2020) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.61.13.19 · Cited by 148
Bhutto, I. A., Baba, T., Merges, C., Juriasinghani, V., McLeod, D. S., & Lutty, G. A. (2011) · British Journal of Ophthalmology · doi:10.1136/bjo.2010.199216 · Cited by 126
“Acknowledgements The authors are grateful to the eye donors and their relatives for their generosity and also to Janet Sunness and Carol Applegate at the Greater Baltimore Medical Center (Baltimore, Maryland, USA) for helping us acquire eyes from subjects with AMD.”
BackgroundInfluentialSelf-citationOn the origin of proteins in human drusen: The meet, greet and stick hypothesis
Bergen, A. A., Arya, S., Koster, C., Pilgrim, M. G., Wiatrek-Moumoulidis, D., van der Spek, P. J., Hauck, S. M., Boon, C. J. F., Emri, E., Stewart, A. J., et al. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.12.003 · Cited by 101
Vogt, S. D., Curcio, C. A., Wang, L., Li, C.-M., McGwin, G., Medeiros, N. E., Philp, N. J., Kimble, J. A., & Read, R. W. (2011) · Experimental Eye Research · doi:10.1016/j.exer.2011.06.002 · Cited by 104
Zhang, J., Qin, Y., Martinez, M., Flores-Bellver, M., Rodrigues, M., Dinabandhu, A., Cao, X., Deshpande, M., Qin, Y., Aparicio-Domingo, S., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci139202 · Cited by 95
Ultrastructure of the human retina in aging and various pathological states
Nag, T. C., & Wadhwa, S. (2012) · Micron · doi:10.1016/j.micron.2012.01.011 · Cited by 88
A local complement response by RPE causes early-stage macular degeneration
Fernandez-Godino, R., Garland, D. L., & Pierce, E. A. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv287 · Cited by 73
Lack of thrombospondin 1 and exacerbation of choroidal neovascularization
Wang, S., Sorenson, C. M., & Sheibani, N. (2012) · Archives of Ophthalmology · doi:10.1001/archopthalmol.2011.1892 · Cited by 61
Zeng, S., Whitmore, S. S., Sohn, E. H., Riker, M. J., Wiley, L. A., Scheetz, T. E., Stone, E. M., Tucker, B. A., & Mullins, R. F. (2016) · The Journal of Pathology · doi:10.1002/path.4669 · Cited by 56
Cabrera, A. P., Bhaskaran, A., Xu, J., Yang, X., Scott, H. A., Mohideen, U., & Ghosh, K. (2016) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.16-19727 · Cited by 53
Makarev, E., Cantor, C., Zhavoronkov, A., Buzdin, A., Aliper, A., & Csoka, A. B. (2014) · Aging · doi:10.18632/aging.100711 · Cited by 50
Murinello, S., Mullins, R. F., Lotery, A. J., Perry, V. H., & Teeling, J. L. (2014) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.13-11821 · Cited by 51
Fei, P., Zaitoun, I., Farnoodian, M., Fisk, D. L., Wang, S., Sorenson, C. M., & Sheibani, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116423 · Cited by 33
Bruch’s Membrane and the Choroid in Age-Related Macular Degeneration
Edwards, M., & Lutty, G. A. (2021) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-66014-7_4 · Cited by 32
Self-citation
Metadata
- Authors
- McLeod, D. S., Grebe, R., Bhutto, I., Merges, C., Baba, T., & Lutty, G. A.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2009-10-01
- Volume
- 50
- Issue
- 10
- Pages
- 4982
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W2012322597
- Cited by
- 567
- References
- 51
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
