Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 287

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Choriocapillaris breakdown precedes retinal degeneration in age-related macular degeneration

Open access
Biesemeier, Antje, Taubitz, Tatjana, Julien, Sylvie, Yoeruek, Efdal, Schraermeyer, Ulrich·2014·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2014.05.003
Open this paper in CoChat — free account

Abstract

This work presents a combined light and electron microscopical approach to investigate the initial breakdown of the retinal pigment epithelium (RPE) and choriocapillaris (CC) in age-related macular degeneration (AMD). Perimacular sections of 12 dry and wet AMD eyes (82 ± 15 years) and 7 age-matched controls (75 ± 10 years) without retinal pathology were investigated. Disease progression was classified into 5 stages of retinal degeneration to investigate the concurrent CC breakdown. Special emphasis was laid on transitions where intact CC-RPE-retina complexes went over into highly atrophied areas. AMD sections showed elevated loss of photoreceptors, RPE and CC (p < 0.01), and thickened Bruch's membrane with increased basal laminar and linear deposits compared with controls. Up to 27% of the CC was lost in controls although RPE and retina were still intact. This primary loss of CC further increased with AMD (up to 100%). The data implicate that CC breakdown already occurs during normal aging and precedes degeneration of the RPE and retina with AMD, defining AMD as a vascular disease. Particular attention should be given to the investigation of early AMD stages and transitional stages to the late stage that reveal a possible sequence of degenerative steps with aging and AMD.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neurobiolaging.2014.05.003

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 48 references

Cited by

See all 287

Metadata

Authors
Biesemeier, A., Taubitz, T., Julien, S., Yoeruek, E., & Schraermeyer, U.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2014-11
Volume
35
Issue
11
Pages
2562-2573
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2014.05.003
OpenAlex
W2143408104
Cited by
287
References
48
FWCI
14.55
Type
journal article
Language
en
Open access
hybrid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Choriocapillaris breakdown precedes retinal degeneration in age-related macular degeneration. https://app.cochat.ai/papers/10.1016/j.neurobiolaging.2014.05.003
The paper
Biesemeier, A., Taubitz, T., Julien, S., Yoeruek, E., & Schraermeyer, U. (2014). Choriocapillaris breakdown precedes retinal degeneration in age-related macular degeneration. Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2014.05.003

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.