The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Potential Role for Angiopoietin 2 in the Regulation of the Blood–Retinal Barrier in Diabetic Retinopathy
Open accessAbstract
PURPOSE: Although VEGF has been identified as an important mediator of the blood-retinal barrier alteration in diabetic retinopathy, the hypothesis for this study was that that other molecules, including the angiopoietins (Ang-1 and -2), may play a role. The expression of angiopoietins was analyzed in an animal model of diabetic retinopathy, and the role of Ang-2 in the regulation of diabetes-induced alterations of vascular permeability was characterized. METHODS: Diabetes was induced in rats, and human retinal endothelial cells (HRECs) were grown in media with 5.5 or 30.5 mM glucose. Levels of Ang-1 and -2 mRNA and protein were analyzed. Fluorescence-based assays were used to assess the effect of Ang-2 on vascular permeability in vivo and in vitro. The effect of Ang-2 on VE-cadherin function was assessed by measuring the extent of tyrosine phosphorylation. RESULTS: Ang-2 mRNA and protein increased in the retinal tissues after 8 weeks of diabetes and in high-glucose-treated cells. Intravitreal injection of Ang-2 in rats produced a significant increase in retinal vascular permeability. Ang-2 increased HREC monolayer permeability that was associated with a decrease in VE-cadherin and a change in monolayer morphology. High glucose and Ang-2 produced a significant increase in VE-cadherin phosphorylation. CONCLUSIONS; Ang-2 is upregulated in the retina in an animal model of diabetes, and hyperglycemia induces the expression of Ang-2 in isolated retinal endothelial cells. Increased Ang-2 alters VE-cadherin function, leading to increased vascular permeability. Thus, Ang-2 may play an important role in increased vasopermeability in diabetic retinopathy.
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Cites
Oxidative Stress and Vascular Disease
Madamanchi, N. R., Vendrov, A., & Runge, M. S. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000150649.39934.13 · Cited by 1,618 · cited 1×
“Studies have also reported that the induction of endothelial cell dysfunction in response to hyperglycemia can be mediated by increased oxidative stress.(40) In addition to ROS, transcriptional regulators of Ang-2 have been shown to be modified by methylglyoxyl, a compound important in the formation of the advanced gl…”
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Cited by
Klaassen, I., Van Noorden, C. J. F., & Schlingemann, R. O. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.02.001 · Cited by 722
Therapeutic targeting of the angiopoietin–TIE pathway
Saharinen, P., Eklund, L., & Alitalo, K. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.278 · Cited by 620
Plastic roles of pericytes in the blood–retinal barrier
Park, D. Y., Lee, J., Kim, J., Kim, K., Hong, S., Han, S., Kubota, Y., Augustin, H. G., Ding, L., Kim, J. W., et al. (2017) · Nature Communications · doi:10.1038/ncomms15296 · Cited by 322
Goncalves, A., & Antonetti, D. A. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00386-0 · Cited by 22
Metadata
- Authors
- Rangasamy, S., Srinivasan, R., Maestas, J., McGuire, P. G., & Das, A.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2011-05-31
- Volume
- 52
- Issue
- 6
- Pages
- 3784
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W2043463860
- Cited by
- 177
- References
- 1
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rangasamy, S., Srinivasan, R., Maestas, J., McGuire, P. G., & Das, A. (2011). A Potential Role for Angiopoietin 2 in the Regulation of the Blood–Retinal Barrier in Diabetic Retinopathy. Investigative Opthalmology & Visual Science. https://doi.org/10.1167/iovs.10-6386
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