The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Biomechanics of the Human Posterior Sclera: Age- and Glaucoma-Related Changes Measured Using Inflation Testing
Open accessAbstract
PURPOSE: The objective of this study was to measure the biomechanical response of the human posterior sclera in vitro and to estimate the effects of age and glaucoma. METHODS: Scleral specimens from 22 donors with no history of glaucoma and 11 donors with a history of glaucoma were excised 3 mm posterior to the equator and affixed to an inflation chamber. Optic nerve cross-sections were graded to determine the presence of axon loss. The time-dependent inflation response was measured in a series of pressure-controlled load-unload tests to 30 mm Hg and creep tests to 15 and 30 mm Hg. Circumferential and meridional strains were computed from the digital image correlation displacements, and midposterior stresses were determined from pressure and deformed geometry. RESULTS: Among normal specimens, older age was predictive of a stiffer response and a thinner sclera. In the age group 75 to 93, diagnosed glaucoma eyes with axon damage were thicker than normal eyes. Both damaged and undamaged glaucoma eyes had a different strain response in the peripapillary sclera characterized by a stiffer meridional response. Undamaged glaucoma eyes had slower circumferential creep rates in the peripapillary sclera than normal eyes. Glaucoma eyes were not different from normal eyes in stresses and strains in the midposterior sclera. CONCLUSIONS: The observed differences in the biomechanical response of normal and glaucoma sclera may represent baseline properties that contribute to axon damage, or may be characteristics that result from glaucomatous disease.
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Self-citationFactors Influencing Optic Nerve Head Biomechanics
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Scleral structure, organisation and disease. A review
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Self-citationDimensions of the human sclera: Thickness measurement and regional changes with axial length
Norman, R. E., Flanagan, J. G., Rausch, S. M. K., Sigal, I. A., Tertinegg, I., Eilaghi, A., Portnoy, S., Sled, J. G., & Ethier, C. R. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2009.11.001 · Cited by 229
Biomechanical Changes in the Sclera of Monkey Eyes Exposed to Chronic IOP Elevations
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The dynamic sclera: Extracellular matrix remodeling in normal ocular growth and myopia development
Harper, A. R., & Summers, J. A. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2014.07.015 · Cited by 275
Optic nerve head biomechanics in aging and disease
Downs, J. C. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.02.011 · Cited by 139
Spatial Patterns and Age-Related Changes of the Collagen Crimp in the Human Cornea and Sclera
Gogola, A., Jan, N.-J., Brazile, B., Lam, P., Lathrop, K. L., Chan, K. C., & Sigal, I. A. (2018) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.17-23474 · Cited by 59
Pijanka, J. K., Abass, A., Sorensen, T., Elsheikh, A., & Boote, C. (2013) · Journal of Applied Crystallography · doi:10.1107/s0021889813022358 · Cited by 38
Metadata
- Authors
- Coudrillier, B., Tian, J., Alexander, S., Myers, K. M., Quigley, H. A., & Nguyen, T. D.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2012-04-02
- Volume
- 53
- Issue
- 4
- Pages
- 1714
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W1991821214
- Cited by
- 335
- References
- 24
- FWCI
- 24.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Coudrillier, B., Tian, J., Alexander, S., Myers, K. M., Quigley, H. A., & Nguyen, T. D. (2012). Biomechanics of the Human Posterior Sclera: Age- and Glaucoma-Related Changes Measured Using Inflation Testing. Investigative Opthalmology & Visual Science. https://doi.org/10.1167/iovs.11-8009
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