Cited by 177Lymphatic System and DiseasesLymphatic Disorders and TreatmentsHippo pathway signaling and YAP/TAZ

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Piezo1 incorporates mechanical force signals into the genetic program that governs lymphatic valve development and maintenance

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Choi, Dongwon, Park, Eunkyung, Jung, Eunson, Cha, Boksik, Lee, Somin, Yu, James, Kim, Paul M., Lee, Sunju, Hong, Yeo Jin, Koh, Chester J., Cho, Chang-Won, Wu, Yifan, Li Jeon, Noo, Wong, Alex K., Shin, Laura, Kumar, S. Ram, Bermejo-Moreno, Ivan, Srinivasan, R. Sathish, Cho, Il-Taeg, Hong, Young-Kwon·2019·JCI Insight

DOI 10.1172/jci.insight.125068PMC PMC6483520

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Abstract

The lymphatic system plays crucial roles in tissue homeostasis, lipid absorption, and immune cell trafficking. Although lymphatic valves ensure unidirectional lymph flows, the flow itself controls lymphatic valve formation. Here, we demonstrate that a mechanically activated ion channel Piezo1 senses oscillating shear stress (OSS) and incorporates the signal into the genetic program controlling lymphatic valve development and maintenance. Time-controlled deletion of Piezo1 using a pan-endothelial Cre driver ( Cdh5[PAC]-CreER T2 ) or lymphatic-specific Cre driver ( Prox1-CreER T2 ) equally inhibited lymphatic valve formation in newborn mice. Furthermore, Piezo1 deletion in adult lymphatics caused substantial lymphatic valve degeneration. Piezo1 knockdown in cultured lymphatic endothelial cells (LECs) largely abrogated the OSS-induced upregulation of the lymphatic valve signature genes. Conversely, ectopic Piezo1 overexpression upregulated the lymphatic valve genes in the absence of OSS. Remarkably, activation of Piezo1 using chemical agonist Yoda1 not only accelerated lymphatic valve formation in animals, but also triggered upregulation of some lymphatic valve genes in cultured LECs without exposure to OSS. In summary, our studies together demonstrate that Piezo1 is the force sensor in the mechanotransduction pathway controlling lymphatic valve development and maintenance, and Piezo1 activation is a potentially novel therapeutic strategy for congenital and surgery-associated lymphedema.

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Coste, B., Mathur, J., Schmidt, M., Earley, T. J., Ranade, S., Petrus, M. J., Dubin, A. E., & Patapoutian, A. (2010) · Science · doi:10.1126/science.1193270 · Cited by 3,316
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Li, J., Hou, B., Tumova, S., Muraki, K., Bruns, A. F., Ludlow, M. J., Sedó, A., Hyman, A. J., McKeown, L., Young, R. S., et al. (2014) · Nature · doi:10.1038/nature13701 · Cited by 1,250
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Ranade, S. S., Qiu, Z., Woo, S., Hur, S. S., Murthy, S. E., Cahalan, S. M., Xu, J., Mathur, J., Bandell, M., Coste, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409233111 · Cited by 931
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Tang, S. S., Gheorghita, M., Hansen, B., Frattolin, J., Kalyviotis, K., Lam, A. J. Y., Tupin, S., Osório, L. A., Boecker, J., Sherwood, J. M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.10.758220
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Wang, S., Wang, B., Wang, Y., Nie, M., Yuan, J., Wu, C., Mi, L., Chen, B., Liu, T., & Jiang, R. (2026) · Brain stimulation · doi:10.1016/j.brs.2026.103245
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Islas, L. D. (2026) · eLife · doi:10.7554/elife.111912.2.sa4

Authors: Choi, D., Park, E., Jung, E., Cha, B., Lee, S., Yu, J., Kim, P. M., Lee, S., Hong, Y. J., Koh, C. J., Cho, C.-W., Wu, Y., Li Jeon, N., Wong, A. K., Shin, L., Kumar, S. R., Bermejo-Moreno, I., Srinivasan, R. S., Cho, I.-T., & Hong, Y.-K.
Affiliations: University of Southern California (US)
Oklahoma Medical Research Foundation (US)
Seoul National University (KR)
Baylor College of Medicine (US)
Korea Food Research Institute (KR)
Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul, South Korea.
Department of Surgery, and
ORCID: Park, Eunkyung
Cha, Boksik
Lee, Somin
Yu, James
Kim, Paul M.
Lee, Sunju
Koh, Chester J.
Cho, Chang-Won
Wu, Yifan
Wong, Alex K.
Kumar, S. Ram
Srinivasan, R. Sathish
Cho, Il-Taeg
Venue: JCI Insight
Publisher: American Society for Clinical Investigation
Published: 2019-03-07
Volume: 4
Issue: 5
ISSN: 2379-3708 (ISSN-L)
DOI: 10.1172/jci.insight.125068
PMC: PMC6483520
OpenAlex: W2911421449
Cited by: 176
References: 57
Citations by year: 2026: 19 · 2025: 22 · 2024: 25 · 2023: 24 · 2022: 28 · 2021: 32 · 2020: 16 · 2019: 9
FWCI: 8.88
Type: journal article
Language: en
Open access: gold
doi.org
Locations: JCI Insight (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: NIH (EY026260,HL121036,HL141857,DE027891,DK114645, HL131652, HL121191)
Korean Research Foundation (NRF-2018R1A2A1A05019550)
Topics: Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords: Piezo1, mechanotransduction, lymphatic endothelial cells, Yoda1, lymphedema, lymphatic system, mechanical force sensing
MeSH terms: Cadherin 5, Animals, Female, Gene Expression Regulation, Humans, Ion Channels, Stress, Mechanical, Antigens, CD, Cadherins, Up-Regulation, Mice, Knockout, Models, Animal, Mechanotransduction, Cellular, Lymphangiogenesis, Lymphatic Vessels, Endothelial Cells, Mice, Transcriptome

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Piezo1 incorporates mechanical force signals into the genetic program that governs lymphatic valve development and maintenance

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