PI3K alpha and delta promote hematopoietic stem cell activation
Open accessAbstract
Many cytokines and chemokines that are important for hematopoiesis activate the PI3K signaling pathway. Because this pathway is frequently mutated and activated in cancer, PI3K inhibitors have been developed for the treatment of several malignancies, and are now being tested in the clinic in combination with chemotherapy. However, the role of PI3K in adult hematopoietic stem cells (HSCs), particularly during hematopoietic stress, is still unclear. We previously showed that the individual PI3K catalytic isoforms P110α or P110β have dispensable roles in HSC function, suggesting redundancy between PI3K isoforms in HSCs. We now demonstrate that simultaneous deletion of P110α and P110δ in double knockout (DKO) HSCs uncovers their redundant requirement in HSC cycling after 5-fluorouracil (5-FU) chemotherapy administration. In contrast, DKO HSCs are still able to exit quiescence in response to other stress stimuli, such as LPS. We found that DKO HSCs and progenitors have impaired sensing of inflammatory signals ex vivo, and that levels of IL1-β and MIG are higher in the bone marrow after LPS than after 5-FU administration. Furthermore, exogenous in vivo administration of IL1-β can induce cell cycle entry of DKO HSCs. Our findings have important clinical implications for the use of PI3K inhibitors in combination with chemotherapy.
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Previous reports indicate that acute IL-1 administration in vivo triggers cell cycle activity in the SLAM compartment.
“Indeed, previous reports indicate that acute IL-1 administration in vivo triggers cell cycle activity in the SLAM compartment (Hemmati et al., 2019; Pietras et al., 2016; Weisser et al., 2016)”
From PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress (2021) · cites this paper as Hemmati et al., 2019
The available indexed passages contain the article title, author information, and a References footer, but no substantive discussion of IL-1 or SLAM cells. Searches for acute IL-1 administration, SLAM cell cycling, “IL-1,” and “SLAM” found no passage that could establish the claim; the available copy appears to omit the decisive article text. (LLM, conf=0.72)
Experimental — accuracy not yet measuredIL-1β promotes hematopoietic regeneration and is capable of briefly driving HSPC into the cell cycle, in large part via activation of the PI3K-AKT pathway.
“Indeed, we and others have shown that IL-1β promotes hematopoietic regeneration and is capable of briefly driving HSPC into the cell cycle, in large part via activation of the PI3K-AKT pathway (Hemmati et al., 2019).”
From PU.1 is required to restrain myelopoiesis during chronic inflammatory stress (2023) · cites this paper as Hemmati et al., 2019
The available indexed passages contain the article title, author affiliations, and publication details, but no findings about IL-1β. Searches for hematopoietic regeneration, HSPC cell-cycle entry, and PI3K-AKT activation returned no relevant passage, so the claim cannot be checked against our copy. (LLM, conf=0.68)
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Cites
NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase
Özeş, O. N., Mayo, L. D., Gustin, J. A., Pfeffer, S. R., Pfeffer, L. M., & Donner, D. B. (1999) · Nature · doi:10.1038/43466 · Cited by 2,175 · see citing works
The emerging mechanisms of isoform-specific PI3K signalling
Vanhaesebroeck, B., Guillermet-Guibert, J., Graupera, M., & Bilanges, B. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2882 · Cited by 1,767 · see citing works
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.
Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D., & Hayakawa, K. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.5.1213 · Cited by 1,604 · see citing works
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
Thorpe, L. M., Yuzugullu, H., & Zhao, J. J. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3860 · Cited by 1,365 · see citing works
Self-citationPten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
Yilmaz, Ö. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature04703 · Cited by 1,272 · see citing works
Identification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential
Adolfsson, J., Månsson, R., Buza-Vidas, N., Hultquist, A., Liuba, K., Jensen, C. T., Bryder, D., Yang, L., Borge, O. J., Thorén, L., et al. (2005) · Cell · doi:10.1016/j.cell.2005.02.013 · Cited by 1,229 · see citing works
Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression
Liang, J., & Slingerland, J. M. (2003) · Cell Cycle · doi:10.4161/cc.2.4.433 · Cited by 885 · see citing works
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
Zhang, J., Grindley, J. C., Yin, T., Jayasinghe, S., He, X. C., Ross, J. T., Haug, J. S., Rupp, D., Porter-Westpfahl, K. S., Wiedemann, L. M., et al. (2006) · Nature · doi:10.1038/nature04747 · Cited by 817 · see citing works
Pietras, E. M., Reynaud, D., Kang, Y.-A., Carlin, D., Calero-Nieto, F. J., Leavitt, A. D., Stuart, J. M., Göttgens, B., & Passegué, E. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.05.003 · Cited by 723 · see citing works
Self-citationPietras, E. M., Mirantes-Barbeito, C., Fong, S., Loeffler, D., Kovtonyuk, L. V., Zhang, S., Lakshminarasimhan, R., Chin, C. P., Techner, J.-M., Will, B., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3346 · Cited by 689 · see citing works
Self-citationSizemore, N., Leung, S., & Stark, G. R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4798 · Cited by 650 · see citing works
Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response
King, K. Y., & Goodell, M. A. (2011) · Nature reviews. Immunology · doi:10.1038/nri3062 · Cited by 565 · see citing works
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L., Thalheimer, F. B., Pastor-Flores, D., Roma, L. P., Renders, S., Zeisberger, P., et al. (2017) · Cell · doi:10.1016/j.cell.2017.04.018 · Cited by 454 · see citing works
Cell cycle regulation in hematopoietic stem cells
Pietras, E. M., Warr, M. R., & Passegué, E. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102131 · Cited by 447 · see citing works
Self-citationInflammation: a key regulator of hematopoietic stem cell fate in health and disease
Pietras, E. M. (2017) · Blood · doi:10.1182/blood-2017-06-780882 · Cited by 417 · see citing works
Self-citationJou, S., Carpino, N., Takahashi, Y., Piekorz, R. P., Chao, J.-R., Carpino, N., Wang, D., & Ihle, J. N. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8580-8591.2002 · Cited by 357 · see citing works
Cabezas-Wallscheid, N., Klimmeck, D., Hansson, J., Lipka, D., Reyes, A., Wang, Q., Weichenhan, D., Lier, A., von Paleske, L., Renders, S., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.07.005 · Cited by 352 · see citing works
Zhao, J. L., Ma, C., O’Connell, R. M., Mehta, A., DiLoreto, R., Heath, J. R., & Baltimore, D. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.01.007 · Cited by 333 · see citing works
Self-citationTakizawa, H., Fritsch, K., Kovtonyuk, L. V., Saito, Y., Yakkala, C., Jacobs, K., Ahuja, A. K., Lopes, M., Hausmann, A., Hardt, W., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.06.013 · Cited by 272 · see citing works
Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice
Kharas, M. G., Okabe, R. O., Ganis, J. J., Gozo, M. C., Khandan, T., Paktinat, M., Gilliland, D. G., & Gritsman, K. (2009) · Blood · doi:10.1182/blood-2009-06-229443 · Cited by 272 · see citing works
Self-citationRegulation of Inflammation- and Infection-Driven Hematopoiesis
Boettcher, S., & Manz, M. G. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.01.004 · Cited by 265 · see citing works
Zelenetz, A. D., Barrientos, J. C., Brown, J. R., Coiffier, B., Delgado, J., Egyed, M., Ghia, P., Illés, Á., Jurczak, W. J., Marlton, P. V., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30671-4 · Cited by 251 · see citing works
Harrison, D., & Lerner, C. P. (1991) · Blood · doi:10.1182/blood.v78.5.1237.1237 · Cited by 242 · see citing works
Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes
Gañán-Gómez, I., Wei, Y., Starczynowski, D. T., Colla, S., Yang, H., Cabrero-Calvo, M., Bohannan, Z. S., Verma, A., Steidl, U., & Garcia-Manero, G. (2015) · Leukemia · doi:10.1038/leu.2015.69 · Cited by 236 · see citing works
Zhao, J. J., Cheng, H.-L. M., Jia, S., Wang, L., Gjoerup, O. V., Mikami, A., & Roberts, T. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607899103 · Cited by 224 · see citing works
Self-citationRamadani, F., Bolland, D. J., Garçon, F., Emery, J. L., Vanhaesebroeck, B., Corcoran, A. E., & Okkenhaug, K. (2010) · Science Signaling · doi:10.1126/scisignal.2001104 · Cited by 203 · see citing works
Magee, J. A., Ikenoue, T., Nakada, D., Lee, J., Guan, K., & Morrison, S. J. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.026 · Cited by 182 · see citing works
Copanlisib: First Global Approval
Markham, A. (2017) · Drugs · doi:10.1007/s40265-017-0838-6 · Cited by 166 · see citing works
B-cell commitment, development and selection
Hardy, R. R., Li, Y., Allman, D., Asano, M., Gui, M., & Hayakawa, K. (2000) · Immunological Reviews · doi:10.1111/j.1600-065x.2000.imr017517.x · Cited by 163 · see citing works
Regulation of Hematopoietic Stem Cell Activity by Inflammation
Schuettpelz, L. G., & Link, D. C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00204 · Cited by 155 · see citing works
PI3Kδ Inhibitors in Cancer: Rationale and Serendipity Merge in the Clinic
Fruman, D. A., & Rommel, C. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0249 · Cited by 137 · see citing works
Karigane, D., Kobayashi, H., Morikawa, T., Ootomo, Y., Sakai, M., Nagamatsu, G., Kubota, Y., Goda, N., Matsumoto, M., Nishimura, E. K., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.05.013 · Cited by 107 · see citing works
Inflammatory Signaling Pathways in Preleukemic and Leukemic Stem Cells
Hemmati, S., Haque, T. Z., & Gritsman, K. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00265 · Cited by 101 · see citing works
Self-citationAn ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion
Baumgärtner, C., Toifl, S., Farlik, M., Halbritter, F., Scheicher, R., Fischer, I., Sexl, V., Bock, C., & Baccarini, M. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.05.003 · Cited by 93 · see citing works
Weisser, M., Demel, U. M., Stein, S., Chen-Wichmann, L., Touzot, F., Santilli, G., Sujer, S., Brendel, C., Siler, U., Cavazzana, M., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.11.028 · Cited by 77 · see citing works
Lampson, B. L., & Brown, J. R. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1384815 · Cited by 77 · see citing works
Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α
Gritsman, K., Yuzugullu, H., Von, T., Yan, H., Clayton, L. K., Fritsch, C. M., Maira, S.-M., Hollingworth, G. J., Choi, C. H., Khandan, T., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci69927 · Cited by 53 · see citing works
Self-citationYuzugullu, H., Baitsch, L., Von, T., Steiner, A., Tong, H., Ni, J., Clayton, L. K., Bronson, R. T., Roberts, T. M., Gritsman, K., et al. (2015) · Nature Communications · doi:10.1038/ncomms9501 · Cited by 47 · see citing works
Self-citationKalaitzidis, D., & Neel, B. G. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003776 · Cited by 37 · see citing works
Haneline, L. S., White, H. A., Yang, F., Shi, C., Orschell, C. M., Kapur, R., & Ingram, D. A. (2005) · Blood · doi:10.1182/blood-2005-05-1985 · Cited by 30 · see citing works
Hebeis, B. J., Vigorito, E., & Turner, M. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320789 · Cited by 25 · see citing works
Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines
Porter, S. N., Cluster, A. S., Signer, R. A. J., Voigtmann, J., Monlish, D. A., Schuettpelz, L. G., & Magee, J. A. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.04.008 · Cited by 22 · see citing works
9-1-1: HSCs Respond to Emergency Calls
Welner, R. S., & Kincade, P. W. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.03.010 · Cited by 12 · see citing works
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Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
de Morrée, A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00568-6 · Cited by 243 · see citing works
PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress
Chavez, J. S., Rabe, J. L., Loeffler, D., Higa, K. C., Hernandez, G., Mills, T. S., Ahmed, N., Gessner, R. L., Ke, Z., Idler, B. M., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201169 · Cited by 91 · see citing works
“, 2014), TNF (Yamashita and Passegue, 2019) and interleukin (IL)-1 (Hemmati et al., 2019; Weisser et al., 2016).”
BackgroundSelf-citationCommon Sources of Inflammation and Their Impact on Hematopoietic Stem Cell Biology
Hormaechea‐Agulla, D., Le, D. T., & King, K. Y. (2020) · Current Stem Cell Reports · doi:10.1007/s40778-020-00177-z · Cited by 46 · see citing works
Molecular regulation of hematopoietic stem cell quiescence
Chen, Z., Guo, Q., Song, G., & Hou, Y. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04200-w · Cited by 49 · see citing works
The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological Significance
Liao, W., Du, C., & Wang, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573915 · Cited by 34 · see citing works
The Akt–mTOR network at the interface of hematopoietic stem cell homeostasis
Wu, F., Chen, Z., Liu, J., & Hou, Y. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.08.009 · Cited by 35 · see citing works
Hematopoietic Stem and Progenitor Cells (HSPCs)
Bujko, K., Kucia, M., Ratajczak, J., & Ratajczak, M. Z. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-31206-0_3 · Cited by 30 · see citing works
The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition
Liu, C., Li, S., Noer, P. R., Kjær-Sørensen, K., Juhl, A. K., Goldstein, A. E., Ke, C., Oxvig, C., & Duan, C. (2020) · eLife · doi:10.7554/elife.52322 · Cited by 27 · see citing works
Regulation of stress-induced hematopoiesis
Anderson, G. A., Rodriguez, M., & Kathrein, K. L. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000589 · Cited by 27 · see citing works
Lee, H.-S., Lee, I.-H., Park, S., & Lee, D.-Y. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/9048089 · Cited by 21 · see citing works
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Hao, J., Zhou, H., Nemes, K., Yen, D. P., Zhao, W., Bramlett, C. S., Wang, B., Lu, R., & Shen, K. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202010118 · Cited by 21 · see citing works
PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells
Ames, K. T., Kaur, I., Shi, Y., Tong, M. M., Sinclair, T., Hemmati, S., Glushakow-Smith, S. G., Tein, E., Gurska, L. M., Steidl, U. G., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade8222 · Cited by 17 · see citing works
Self-citationAljoufi, A., Zhang, C., Ropa, J. P., Chang, W., Palam, L. R., Cooper, S. H., Ramdas, B., Capitano, M. L., Broxmeyer, H. E., & Kapur, R. (2022) · Blood · doi:10.1182/blood.2022015499 · Cited by 17 · see citing works
Marino‐Merlo, F., Grelli, S., Mastino, A., Lai, M., Ferrari, P., Nicolini, A., Pistello, M., & Macchi, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914807 · Cited by 16 · see citing works
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Bhattacharjee, R., Ghosh, S., Nath, A., Basu, A., Biswas, O., Patil, C. R., & Kundu, C. N. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103753 · Cited by 16 · see citing works
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“Indeed, we and others have shown that IL1β promotes hematopoietic regeneration and is capable of briefly driving HSPC into the cell cycle, in large part via activation of the PI3K-AKT pathway (Hemmati et al., 2019).”
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Aytenfisu, T. Y., Campbell, H. M., Chakrabarti, M., Amzel, L. M., & Gabelli, S. B. (2022) · Current topics in microbiology and immunology · doi:10.1007/978-3-031-06566-8_1 · Cited by 9 · see citing works
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Ikhtiar, F., Jamal, A., & Bokhari, S. M. S. M. (2025) · Discover Oncology · doi:10.1007/s12672-025-03535-7 · Cited by 8 · see citing works
Thummar, K., & Rathinam, C. V. (2022) · Scientific Reports · doi:10.1038/s41598-022-16548-x · Cited by 7 · see citing works
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Dalecki, A. G., Greer, B. D., Duverger, A. E., Strange, E. L., Carlin, E., Wagner, F., Shi, B., Lowman, K. E., Perez, M. D., Tidwell, C., et al. (2022) · Journal of Virology · doi:10.1128/jvi.01974-21 · Cited by 7 · see citing works
He, W., Qiu, H., Feng, Y., Qiu, Q., Zheng, L., Pan, C., Cui, X. J., Sun, Y., Wang, B., & Hu, Y. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08050-9 · Cited by 6 · see citing works
Ye, M., Liu, G., Yang, Y., Yang, H., Ren, J., Chen, W., & Gao, Z. (2023) · Scientific Reports · doi:10.1038/s41598-023-44672-9 · Cited by 4 · see citing works
Li, Z., Qin, H., Zhang, Y., He, X., Bao, X., Sun, G., Cui, C., Xu, X., Liu, X., Yang, J., et al. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.108494 · Cited by 4 · see citing works
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Self-citationGualtiero, G., Buso, H., Coopmans, E. C., Milito, C., Firinu, D., van Dalm, V., & Cinetto, F. (2026) · ImmunoTargets and Therapy · doi:10.2147/itt.s582718 · Cited by 1 · see citing works
Liu, C., Li, S., Noer, P. R., Kjær-Sørensen, K., Ke, C., Oxvig, C., & Duan, C. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/792978 · Cited by 1 · see citing works
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Ames, K. T., Kaur, I., Shi, Y., Tong, M., Sinclair, T., Hemmati, S., Glushakow-Smith, S. G., Tein, E., Gurska, L. M., Dubin, R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.04.412593
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Borger, D. K., Mitchell, S., Nakahara, F., Colombo, D., Torres, L. S., Garforth, S., Sidoli, S., Krijgsveld, J., Silberstein, L., Frenette, P. S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.07.669162
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Xiao, T., Xie, Z., Yao, L., Zhao, K., Zeng, Y. A., & Hu, C. (2026) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2026.103690
Exploiting an epigenetic resistance mechanism to PI3-kinase inhibition in leukemic stem cells
Glushakow-Smith, S. G., Kaur, I., Sidoli, S., Hemmati, S., Angeles, E., Sinclair, T., Chakraborty, S., Battle, A., Ames, K., Narayanagari, S.-R., et al. (2026) · Leukemia · doi:10.1038/s41375-026-03145-4
Self-citation
- Authors
- Hemmati, S., Sinclair, T., Tong, M., Bartholdy, B., Okabe, R. O., Ames, K., Ostrodka, L., Haque, T., Kaur, I., Mills, T. S., Agarwal, A., Pietras, E. M., Zhao, J. J., Roberts, T. M., & Gritsman, K.
- Affiliations
- Albert Einstein College of Medicine (US)
- University of Colorado Anschutz (US)
- Oregon Health & Science University (US)
- Dana-Farber Cancer Institute (US)
- Corresponding author
- Gritsman, Kira
- ORCID
- Venue
- JCI Insight
- Published
- 2019-07-11
- Volume
- 4
- Issue
- 13
- ISSN
- 2379-3708 (ISSN-L)
- PMC
- PMC6629136
- OpenAlex
- W2945935815
- Cited by
- 40
- References
- 43
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 7 · 2022: 12 · 2021: 4 · 2020: 7 · 2019: 2
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- JCI Insight (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA196973, K08CA149208, R35 CA210057, R01CA187918, P30CA013330)
- American Society of Hematology (American Society of Hematology,Junior Faculty Scholar Award)
- New York State Department of Health (C30292GG)
- National Institute of Health (R01DK119394)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Keywords
- phosphatidylinositol 3-kinase, PI3Kα, PI3Kδ, hematopoietic stem cells, p110α, p110δ, hematopoietic stress, 5-fluorouracil, LPS, IL-1β, MIG, stem cell quiescence, cell cycle entry, PI3K inhibitors, combination chemotherapy, bone marrow inflammation
- MeSH terms
- Animals, Antineoplastic Agents, Bone Marrow, Cell Cycle, Disease Models, Animal, Enzyme Inhibitors, Female, Fluorouracil, Hematopoiesis, Hematopoietic Stem Cells, Lipopolysaccharides, Male, Signal Transduction, Gene Expression Regulation, Enzymologic, Mice, Knockout, Phosphatidylinositol 3-Kinases, Protein Isoforms, Gene Knockout Techniques, Class I Phosphatidylinositol 3-Kinases
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