Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Open accessAbstract
Dormant hematopoietic stem cells (dHSCs) are atop the hematopoietic hierarchy. The molecular identity of dHSCs and the mechanisms regulating their maintenance or exit from dormancy remain uncertain. Here, we use single-cell RNA sequencing (RNA-seq) analysis to show that the transition from dormancy toward cell-cycle entry is a continuous developmental path associated with upregulation of biosynthetic processes rather than a stepwise progression. In addition, low Myc levels and high expression of a retinoic acid program are characteristic for dHSCs. To follow the behavior of dHSCs in situ, a Gprc5c-controlled reporter mouse was established. Treatment with all-trans retinoic acid antagonizes stress-induced activation of dHSCs by restricting protein translation and levels of reactive oxygen species (ROS) and Myc. Mice maintained on a vitamin A-free diet lose HSCs and show a disrupted re-entry into dormancy after exposure to inflammatory stress stimuli. Our results highlight the impact of dietary vitamin A on the regulation of cell-cycle-mediated stem cell plasticity. VIDEO ABSTRACT.
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ATRA antagonizes stress-induced activation of dormant hematopoietic stem cells by restricting protein translation and oxidative stress.
“ATRA antagonizes stress-induced activation of dormant hematopoietic stem cells by restricting protein translation and oxidative stress8.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [8]
When mice were fed a vitamin A-free diet to deplete the RA reservoir, animals suffered functional impairment of hematopoietic stem cells and their numbers were unable to recover even after injection with an immunostimulant.
“When mice were fed a vitamin A-free diet to deplete the RA reservoir, animals suffered, among other effects, functional impairment of hematopoietic stem cells and their numbers were unable to recover even after injection with an immunostimulant8.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [8]
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The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing
Pucella, J. N., Upadhaya, S., & Reizis, B. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020520-114601 · Cited by 53 · see citing works
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PI3K alpha and delta promote hematopoietic stem cell activation
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- Authors
- Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L., Thalheimer, F. B., Pastor-Flores, D., Roma, L. P., Renders, S., Zeisberger, P., Przybylla, A., Schönberger, K., Scognamiglio, R., Altamura, S., Florian, C. M., Fawaz, M., Vonficht, D., Tesio, M., Collier, P., Pavlinic, D., Geiger, H., Schroeder, T., Benes, V., Dick, T. P., Rieger, M. A., Stegle, O., & Trumpp, A.
- Affiliations
- European Bioinformatics Institute (GB)
- German Cancer Research Center (DE)
- Goethe University Frankfurt (DE)
- Heidelberg University (DE)
- European Molecular Biology Laboratory (DE)
- Universität Ulm (DE)
- ETH Zurich (CH)
- Corresponding author
- Trumpp, Andreas
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 169
- Issue
- 5
- Pages
- 807-823.e19
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2610808603
- Cited by
- 454
- References
- 78
- Citations by year
- 2026: 31 · 2025: 47 · 2024: 51 · 2023: 53 · 2022: 69 · 2021: 48 · 2020: 48 · 2019: 53 · 2018: 44 · 2017: 9
- FWCI
- 32.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- UK Medical Research Council (MRC (MR/M01536X/1, FOR2033, SFB873)
- Deutsche Forschungsgemeinschaft (DFG)
- Dietmar Hopp Foundation
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- hematopoietic stem cells, stem cell quiescence, retinoic acid signaling, vitamin A, c-Myc, cell cycle entry, stem cell plasticity, reactive oxygen species, mRNA translation, inflammatory stress, single-cell RNA sequencing
- MeSH terms
- Animals, Cell Cycle, Cell Survival, Diet, Hematopoietic Stem Cells, Poly I-C, Stress, Physiological, Tretinoin, Vitamin A, Vitamins, Signal Transduction, Reactive Oxygen Species, Cell Culture Techniques, Gene Expression Profiling, Receptors, G-Protein-Coupled, Mice, Biosynthetic Pathways, Single-Cell Analysis
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