The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice
Open accessAbstract
Surgery can induce cognitive decline, a risk that increases with advancing age. In rodents, postoperative cognitive decline (POCD) is associated with the inflammatory activation of hippocampal microglia. To examine the role of microglia in POCD, we inhibited the colony-stimulating factor 1 receptor (CSF1R) in adult mice, effectively depleting CNS microglia. Surgical trauma (tibial fracture) reduced the ability of mice to remember a conditioned response learned preoperatively, a deficit more pronounced and persistent in mice with diet-induced obesity (DIO). Whereas microglial depletion by itself did not affect learning or memory, perioperative microglial depletion remarkably protected mice, including those with DIO, from POCD. This protection was associated with reduced hippocampal levels of inflammatory mediators, abrogation of hippocampal recruitment of CCR2 + leukocytes, and higher levels of circulating inflammation-resolving factors. Targeting microglia may thus be a viable strategy to mitigate the development of POCD, particularly in those with increased vulnerability.
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Cites
From inflammation to sickness and depression: when the immune system subjugates the brain
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BackgroundMicroglia as a source and target of cytokines
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BackgroundPredictors of Cognitive Dysfunction after Major Noncardiac Surgery
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Cited by
Valdearcos, M., Douglass, J. D., Robblee, M. M., Dorfman, M. D., Stifler, D. R., Bennett, M. L., Gerritse, I., Fasnacht, R., Barres, B. A., Thaler, J. P., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.015 · Cited by 477
Self-citationSafavynia, S. A., & Goldstein, P. A. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00752 · Cited by 339
Lopez‐Rodriguez, A. B., Hennessy, E., Murray, C. L., Nazmi, A., Delaney, H. J., Healy, D., Fagan, S. G., Rooney, M., Stewart, E., Lewis, A., et al. (2021) · Alzheimer's & Dementia · doi:10.1002/alz.12341 · Cited by 293
The neuroimmunology of social-stress-induced sensitization
Biltz, R. G., Sawicki, C. M., Sheridan, J. F., & Godbout, J. P. (2022) · Nature Immunology · doi:10.1038/s41590-022-01321-z · Cited by 132
Protective Microglial Subset in Development, Aging, and Disease: Lessons From Transcriptomic Studies
Benmamar-Badel, A., Owens, T., & Wlodarczyk, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00430 · Cited by 124
Metadata
- Authors
- Feng, X., Valdearcos, M., Uchida, Y., Lutrin, D., Maze, M., & Koliwad, S. K.
- Venue
- JCI Insight
- Published
- 2017-04-06
- Volume
- 2
- Issue
- 7
- Pages
- e91229-e91229
- ISSN
- 2379-3708 (ISSN-L)
- OpenAlex
- W2604235446
- Cited by
- 361
- References
- 45
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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