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KLF2 and KLF4 control endothelial identity and vascular integrity
Open accessAbstract
Maintenance of vascular integrity in the adult animal is needed for survival, and it is critically dependent on the endothelial lining, which controls barrier function, blood fluidity, and flow dynamics. However, nodal regulators that coordinate endothelial identity and function in the adult animal remain poorly characterized. Here, we show that endothelial KLF2 and KLF4 control a large segment of the endothelial transcriptome, thereby affecting virtually all key endothelial functions. Inducible endothelial-specific deletion of Klf2 and/or Klf4 reveals that a single allele of either gene is sufficient for survival, but absence of both (EC-DKO) results in acute death from myocardial infarction, heart failure, and stroke. EC-DKO animals exhibit profound compromise in vascular integrity and profound dysregulation of the coagulation system. Collectively, these studies establish an absolute requirement for KLF2/4 for maintenance of endothelial and vascular integrity in the adult animal.
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“Cells fated for the endothelial terminal state diverge at E10.5 activating regulators of angiogenesis, such as Tbx1 and Foxc2, as well as genes associated with blood flow-associated shear stress, including Klf2 and Klf4”
From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Sangwung et al., 2017
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“the endothelial cluster is enriched for mechanosensitive ion channels and transcription factors associated with flow-induced shear stress and angiogenesis, such as Piezo1/2, Klf2/4, Foxc2, and Tbx1”
From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Sangwung et al., 2017
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Cites
Finishing the euchromatic sequence of the human genome
International Human Genome Sequencing Consortium (2004) · Nature · doi:10.1038/nature03001 · Cited by 4,971
Phenotypic Heterogeneity of the Endothelium
Aird, W. C. (2007) · Circulation Research · doi:10.1161/01.res.0000255691.76142.4a · Cited by 1,824
Guidelines for the diagnosis and management of disseminated intravascular coagulation
Levi, M. M., Toh, C., Thachil, J. V., & Watson, H. G. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07600.x · Cited by 1,116
Klf4 is a transcription factor required for establishing the barrier function of the skin
Segre, J. A., Bauer, C. R., & Fuchs, E. V. (1999) · Nature Genetics · doi:10.1038/11926 · Cited by 810
KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation
SenBanerjee, S., Lin, Z., Atkins, G. B., Greif, D. M., Rao, R. M., Kumar, A., Feinberg, M. W., Chen, Z., Simon, D. I., Luscinskas, F. W., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031132 · Cited by 734
Self-citationIntegration of flow-dependent endothelial phenotypes by Kruppel-like factor 2
Parmar, K. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24787 · Cited by 710
Dekker, R. J., van Soest, S., Fontijn, R. D., Salamanca, S., de Groot, P. G., VanBavel, E., Pannekoek, H., & Horrevoets, A. J. G. (2002) · Blood · doi:10.1182/blood-2002-01-0046 · Cited by 694
Role of Krüppel-Like Transcription Factors in Endothelial Biology
Atkins, G. B., & Jain, M. K. (2007) · Circulation Research · doi:10.1161/01.res.0000267856.00713.0a · Cited by 422
Self-citationKruppel-like Factor 4 Regulates Endothelial Inflammation
Hamik, A., Lin, Z., Kumar, A., Balcells, M., Sinha, S., Katz, J. P., Feinberg, M. W., Gerszten, R. E., Edelman, E. R., & Jain, M. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700078200 · Cited by 391
Self-citationKruppel-Like Factor 2 (KLF2) Regulates Endothelial Thrombotic Function
Lin, Z., Kumar, A., SenBanerjee, S., Staniszewski, K. E., Parmar, K. M., Vaughan, D. E., Gimbrone, M. A., Balasubramanian, V., García‐Cardeña, G., & Jain, M. K. (2005) · Circulation Research · doi:10.1161/01.res.0000159707.05637.a1 · Cited by 385
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Eelen, G., Treps, L., Li, X., & Carmeliet, P. (2020) · Circulation Research · doi:10.1161/circresaha.120.316851 · Cited by 589
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Self-citationAndueza, A., Kumar, S., Kim, J. Y., Kang, D. W., Mumme, H., Perez, J. I., Villa-Roel, N., & Jo, H. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108491 · Cited by 245
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Miao, Y., Ajami, N. E., Huang, T.-S., Lin, F., Lou, C., Wang, Y., Li, S., Kang, J., Munkacsi, H., Maurya, M. R., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02113-y · Cited by 180
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Zeng, H., Hou, Y., Zhou, X., Lang, L., Luo, H., Sun, Y., Wan, X., Yuan, T., Wang, R., Liu, Y., et al. (2022) · Theranostics · doi:10.7150/thno.74753 · Cited by 138
Maas, S. L., Soehnlein, O., & Viola, J. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02739 · Cited by 147
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Ganta, V. C., Choi, M., Farber, C. R., & Annex, B. H. (2019) · Circulation · doi:10.1161/circulationaha.118.034165 · Cited by 123
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Fan, Y., Lu, H., Liang, W., Hu, W., Zhang, J., & Chen, Y. E. (2017) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjx037 · Cited by 122
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Sweet, D. R., Fan, L., Hsieh, P. N., & Jain, M. K. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00006 · Cited by 113
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Chang, C., Liao, Y.-C., Huang, C., Lin, C.-M., Cheung, C. H. Y., Ruan, J., Yu, W.-H., Tsai, Y.-T., Lin, I.-J., Huang, C., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110016 · Cited by 108
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Maurya, M. R., Gupta, S., Li, J. Y.-S., Ajami, N. E., Chen, Z., Shyy, J. Y.-J., Chien, S., & Subramaniam, S. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023236118 · Cited by 100
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Lotto, J., Drissler, S., Cullum, R., Wei, W., Setty, M., Bell, E. M., Boutet, S. C., Nowotschin, S., Kuo, Y.-Y., Garg, V., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.012 · Cited by 86
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Moonen, J.-R. A. J., Chappell, J., Shi, M., Shinohara, T., Li, D., Mumbach, M. R., Zhang, F., Nair, R. V., Nasser, J., Mai, D. H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32566-9 · Cited by 78
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He, M., Huang, T.-S., Li, S., Hong, H.-C., Chen, Z. B., Martin, M., Zhou, X., Huang, H., Su, S., Zhang, J., et al. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.312301 · Cited by 70
Lu, Y. W., Martino, N., Gerlach, B. D., Lamar, J. M., Vincent, P. A., Adam, A. P., & Schwarz, J. J. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314978 · Cited by 73
Self-citationThe role of monocytosis and neutrophilia in atherosclerosis
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Zhang, X., Wang, L., Han, Z., Dong, J., Pang, D., Fu, Y., & Li, L. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01780-x · Cited by 69
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Tamargo, I. A., Baek, K. I., Xu, C., Kang, D. W., Kim, Y., Andueza, A., Williams, D., Demos, C., Villa-Roel, N., Kumar, S., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.064735 · Cited by 67
Self-citationA perfusable, vascularized kidney organoid-on-chip model
Kroll, K. T., Homan, K. A., Uzel, S. G. M., Mata, M. M., Wolf, K. J., Rubins, J. E., & Lewis, J. A. (2024) · Biofabrication · doi:10.1088/1758-5090/ad5ac0 · Cited by 68
Xu, Y., Xu, S., Liu, P., Koroleva, M., Zhang, S., Si, S., & Jin, Z. G. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.007134 · Cited by 63
Exploring the Role of Endothelial Cell Resilience in Cardiovascular Health and Disease
Gao, Y., & Galis, Z. S. (2021) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.120.314346 · Cited by 62
Wang, C., Dong, J., Sun, J., Huang, S.-K., Wu, F., Zhang, X., Pang, D., Fu, Y., & Li, L. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.06.025 · Cited by 60
Xu, S., Liu, Y., Ding, Y., Luo, S., Zheng, X., Wu, X., Liu, Z., Ilyas, I., Chen, S., Han, S., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00690-5 · Cited by 60
Self-citationYang, H., Xi, X., Zhao, B., Su, Z., & Wang, Z. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.205 · Cited by 56
Atheroprone flow enhances the endothelial-to-mesenchymal transition
Lai, B., Li, Z., He, M., Wang, Y., Chen, L., Zhang, J., Yang, Y., & Shyy, J. Y.-J. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00213.2018 · Cited by 53
Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis
Hess, D. L., Kelly‐Goss, M. R., Cherepanova, O. A., Nguyen, A. T., Baylis, R. A., Tkachenko, S., Annex, B. H., Peirce, S. M., & Owens, G. K. (2019) · Nature Communications · doi:10.1038/s41467-019-08811-z · Cited by 52
Lee, O.-H., Woo, Y. M., Moon, S., Lee, J., Park, H., Jang, H. S., Park, Y., Bae, S., Park, K., Heo, J. H., et al. (2020) · Aging · doi:10.18632/aging.202176 · Cited by 52
Caradu, C., Couffinhal, T., Chapouly, C., Guimbal, S., Hollier, P.-L., Ducasse, É., Bura-Rivière, A., Dubois, M., Gadeau, A., & Renault, M. (2018) · Circulation Research · doi:10.1161/circresaha.118.313177 · Cited by 50
Qiao, S., Zhang, W., Yin, Y., Wei, Z., Chen, F., Zhao, J., Sun, X., Mu, D., Xie, J., & Xu, B. (2020) · Theranostics · doi:10.7150/thno.45459 · Cited by 53
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Stratman, A. N., Burns, M. C., Farrelly, O. M., Davis, A. E., Li, W., Pham, V. N., Castranova, D., Yano, J. J., Goddard, L. M., Nguyen, O., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01462-7 · Cited by 47
Lu, H., Yuan, P., Ma, X., Jiang, X., Liu, S., Ma, C., Philipsen, S., Zhang, Q., Yang, J., Xu, F., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36409-z · Cited by 48
Peghaire, C. R., Dufton, N., Lang, M., Salles‐Crawley, I. I., Ahnström, J., Kalna, V., Raimondi, C., Pericleous, C., Inuabasi, L., Kiseleva, R. Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12897-w · Cited by 47
Tajadura, V., Hansen, M. H., Smith, J., Charles, H., Rickman, M., Farrell‐Dillon, K., Claro, V., Warboys, C. M., & Ferro, A. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2687-6 · Cited by 45
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A review of KLF4 and inflammatory disease: Current status and future perspective
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Abello, J., Raghavan, S. A., Yien, Y. Y., & Stratman, A. N. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102404 · Cited by 38
Sarvestani, S. K., Signs, S. A., Lefebvre, V., Mack, S. C., Ni, Y., Morton, A. R., Chan, E. R., Li, X., Fox, P. L., Ting, A. H., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25617 · Cited by 38
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Tang, X., Luo, Y., Yuan, D., Calandrelli, R., Malhi, N. K., Sriram, K., Miao, Y., Lou, C.-H., Tsark, W. M. K., Tapia, A., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci161759 · Cited by 38
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Chen, F., Zhan, J., Liu, M., Mamun, A. A., Huang, S., Tao, Y., Zhao, J., Zhang, Y., Xu, Y., He, Z., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85692 · Cited by 36
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Bishop, C., Yan, K., Nguyen, W., Rawle, D. J., Tang, B., Larcher, T., & Suhrbier, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1382655 · Cited by 40
Li, H., Wang, Y., Liu, J., Chen, X., Duan, Y., Wang, X., Shen, Y., Kuang, Y., Zhuang, T., Tomlinson, B., et al. (2020) · Theranostics · doi:10.7150/thno.48153 · Cited by 36
Thakar, S., Katakia, Y. T., Ramakrishnan, S. K., Thakkar, N. P., & Majumder, S. (2021) · Cells · doi:10.3390/cells10102548 · Cited by 36
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Denis, J.-F., Diagbouga, M. R., Molica, F., Hautefort, A., Linnerz, T., Watanabe, M., Lemeille, S., Bertrand, J. Y., & Kwak, B. R. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00080 · Cited by 35
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Yeh, C.-F., Cheng, S.-H., Lin, Y.-S., Shentu, T.-P., Huang, R.-T., Zhu, J., Chen, Y.-T., Kumar, S., Lin, M.-S., Kao, H.-L., et al. (2022) · Science Advances · doi:10.1126/sciadv.abl8096 · Cited by 44
Self-citationThe Atherosclerotic Plaque Microenvironment as a Therapeutic Target
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Lu, Y. W., Lowery, A. M., Sun, L.-Y., Singer, H. A., Dai, G., Adam, A. P., Vincent, P. A., & Schwarz, J. J. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309180 · Cited by 34
Self-citationPost-translational modifications of S1PR1 and endothelial barrier regulation
Anwar, M., & Mehta, D. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158760 · Cited by 34
Tirone, M., Giovenzana, A., Vallone, A., Zordan, P., Sormani, M., Nicolosi, P. A., Meneveri, R., Gigliotti, C. R., Spinelli, A. E., Bocciardi, R., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01640 · Cited by 32
Caliceti, C., Malaguti, M., Marracino, L., Barbalace, M. C., Rizzo, P., & Hrelia, S. (2022) · Antioxidants · doi:10.3390/antiox11091786 · Cited by 37
Fan, Z., Ardicoglu, R., Batavia, A. A., Rust, R., von Ziegler, L., Waag, R., Zhang, J., Desgeorges, T., Sturman, O., Dang, H., et al. (2023) · Angiogenesis · doi:10.1007/s10456-023-09870-z · Cited by 34
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Wang, Q., He, Y., Kan, W., Li, F., Ji, X., Wu, X., Wang, X., Zhang, Y., & Chen, J. (2019) · Europe PMC (PubMed Central) · Cited by 31
Well-Known and Novel Players in Endothelial Dysfunction: Updates on a Notch(ed) Landscape
Fortini, F., Vieceli Dalla Sega, F., Marracino, L., Severi, P., Rapezzi, C., Rizzo, P., & Ferrari, R. (2021) · Biomedicines · doi:10.3390/biomedicines9080997 · Cited by 30
Pandey, D., Nomura, Y., Rossberg, M. C., Hori, D., Bhatta, A., Keceli, G., Leucker, T. M., Santhanam, L., Shimoda, L. A., Berkowitz, D. E., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310660 · Cited by 31
Yang, Y., Mumau, M. D., Tober, J. M., Zhu, Q., Bennett, L. F., Hong, C. C., Sung, D. C., Keller, T. C. S., Uzun, Y., Gao, P., et al. (2022) · Blood · doi:10.1182/blood.2021013934 · Cited by 28
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Saum, K. L., Campos, B., Celdran‐Bonafonte, D., Nayak, L. V., Sangwung, P., Thakar, C. V., Roy‐Chaudhury, P., & Owens, A. P. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007566 · Cited by 30
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Kok, F. O., & Baker, A. H. (2019) · Vascular Pharmacology · doi:10.1016/j.vph.2018.06.004 · Cited by 30
Dai, Y., Yan, T., & Gao, Y. (2020) · Diagnostic Pathology · doi:10.1186/s13000-020-00942-y · Cited by 30
Gao, C., Qian, H., Shi, Q., & Zhang, H. (2020) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt-19-700 · Cited by 30
Přibyl, M., Hodný, Z., & Kubíková, I. (2021) · Genes · doi:10.3390/genes12010108 · Cited by 30
Linna-Kuosmanen, S., Schmauch, E., Galani, K., Ojanen, J., Boix, C. A., Örd, T., Toropainen, A., Singha, P., Moreau, P. R., Harju, K., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101556 · Cited by 29
Blazeski, A., Floryan, M. A., Zhang, Y., Fajardo‐Ramírez, Ó. R., Meibalan, E., Ortiz-Urbina, J., Angelidakis, E., Shelton, S. E., Kamm, R. D., & García‐Cardeña, G. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122686 · Cited by 26
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Yee, M., Cohen, E. D., Domm, W., Porter, G. A., Jr., McDavid, A., & O’Reilly, M. A. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00409.2017 · Cited by 27
Huang, T., Yin, J., Ren, S., & Zhang, X. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156288 · Cited by 26
Helle, E., Ampuja, M., Antola, L., & Kivelä, R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.591450 · Cited by 25
Kant, S., Tran, K.-V., Kvandová, M., Caliz, A. D., Yoo, H.-J., Learnard, H., Dolan, A. C., Craige, S. M., Hall, J. D., Jiménez, J. M., et al. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.317066 · Cited by 25
Yang, K., Cui, S., Wang, J., Xu, T., Du, H., Yue, H., Ye, H., Guo, J., Zhang, J., Li, P., et al. (2023) · Advanced Science · doi:10.1002/advs.202302231 · Cited by 24
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Self-citationZimmermann, M., Beer, L., Ullrich, R., Lukovic, D., Simader, E., Traxler, D., Wagner, T., Nemec, L., Altenburger, L. M., Zuckermann, A. O., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17955 · Cited by 22
Boriushkin, E., Zhang, H., Becker, M., Peachey, J., Shatat, M. A., Adams, R. H., & Hamik, A. (2019) · Angiogenesis · doi:10.1007/s10456-018-9657-y · Cited by 22
Sweet, D. R., Padmanabhan, R., Liao, X., Dashora, H. R., Tang, X., Nayak, L. V., Jain, R., Val, S. D., Vinayachandran, V., & Jain, M. K. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.121.024303 · Cited by 20
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Cho, D. I., Ahn, J. H., Kang, B. G., Hwang, I., Cho, H. H., Jun, J. H., Yoo, J. Y., Cho, M., Yoo, S. J., Kim, H.-S., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.322700 · Cited by 21
Demos, C., Johnson, J., Andueza, A., Park, C. J., Kim, Y., Villa-Roel, N., Kang, D. W., Kumar, S., & Jo, H. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.979745 · Cited by 19
Self-citation
Metadata
- Authors
- Sangwung, P., Zhou, G., Nayak, L., Chan, E. R., Kumar, S., Kang, D.-W., Zhang, R., Liao, X., Lu, Y., Sugi, K., Fujioka, H., Shi, H., Lapping, S. D., Ghosh, C. C., Higgins, S. J., Parikh, S. M., Jo, H., & Jain, M. K.
- Affiliations
- Cardiovascular Institute Hospital (JP)
- University Hospitals of Cleveland (US)
- Case Western Reserve University (US)
- Georgia Institute of Technology (US)
- Beth Israel Deaconess Medical Center (US)
- ORCID
- Venue
- JCI Insight
- Published
- 2017-02-23
- Volume
- 2
- Issue
- 4
- Pages
- e91700-e91700
- ISSN
- 2379-3708 (ISSN-L)
- PMC
- PMC5313061
- OpenAlex
- W2588645651
- Cited by
- 247
- References
- 33
- Citations by year
- 2026: 31 · 2025: 24 · 2024: 32 · 2023: 31 · 2022: 29 · 2021: 23 · 2020: 31 · 2019: 20 · 2018: 16 · 2017: 10
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- JCI Insight (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association (16POST31200017)
- Case Western Reserve University
- School of Medicine, Case Western Reserve University
- National Institutes of Health (12SDG12070077)
- National Heart, Lung, and Blood Institute (R01HL125275, R01HL110630, R01HL086548, K08HL121131, R01HL112486, R01HL119195, R01HL093234)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- KLF2, KLF4, vascular integrity, endothelial-specific knockout, endothelial transcriptome, endothelial barrier function, coagulation system, myocardial infarction, heart failure, stroke
- MeSH terms
- Kruppel-Like Factor 4, Animals, Blood Coagulation, Blood Coagulation Disorders, Capillary Permeability, Endothelium, Vascular, Gene Expression Regulation, Heart Failure, Myocardial Infarction, Mice, Knockout, Stroke, Mice, Kruppel-Like Transcription Factors
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