Exploring the Role of Endothelial Cell Resilience in Cardiovascular Health and Disease
Open accessAbstract
Traditionally, much research effort has been invested into focusing on disease, understanding pathogenic mechanisms, identifying risk factors, and developing effective treatments. A few recent studies unraveling the basis for absence of disease, including cardiovascular disease, despite existing risk factors, a phenomenon commonly known as resilience, are adding new knowledge and suggesting novel therapeutic approaches. Given the central role of endothelial function in cardiovascular health, we herein provide a number of considerations that warrant future research and considering a paradigm shift toward identifying the molecular underpinnings of endothelial resilience.
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Interplay between the endothelium and established exerkines such as nitric oxide and VEGF influences vascular tone, inflammation, regeneration and thrombosis, and has an important role in cardiovascular and overall resilience.
“interplay between the endothelium and established exerkines, such as nitric oxide52 and VEGF27, has been shown to influence vascular tone, inflammation, regeneration and thrombosis, and has an important role in cardiovascular and overall resilience67.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [67]
The interplay between the endothelium and the exerkines NO• and VEGF can modulate vascular tone, inflammation, regeneration, and thrombosis, with an important role in cardiovascular resilience.
“Notably, the interplay between the endothelium and the exerkines NO• 174 and VEGF 175 can modulate vascular tone, inflammation, regeneration, and thrombosis, with an important role in cardiovascular resilience-that is, absence of actual CVD despite existing risk factors.176”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [176]
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IGFBP6 contributes to vascular resilience
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- Authors
- Gao, Y., & Galis, Z. S.
- Affiliations
- National Institutes of Health (US)
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2021-01
- Volume
- 41
- Issue
- 1
- Pages
- 179-185
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W3094200694
- Cited by
- 62
- References
- 48
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 17 · 2023: 15 · 2022: 7 · 2021: 5
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- endothelial function, cardiovascular disease, cardiovascular health, cardiovascular risk factors, treatment options
- MeSH terms
- Animals, Cardiovascular Diseases, Endothelium, Vascular, Humans, Risk Factors, Vasodilation
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