The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation
Abstract
Different members of the Rel/NF-κB family may play different roles in immunity and inflammation. We report here that c-Rel–deficient mice are resistant to autoimmune encephalomyelitis and are defective in Th1, but not Th2 responses. The Th1 deficiency appears to be caused by selective blockade of IL-12 production by c-Rel–deficient antigen-presenting cells, as well as by a complete abrogation of IFN-γ expression in c-Rel–deficient T cells. Interestingly, c-Rel deficiency does not affect T-bet expression, suggesting that c-Rel may act downstream of T-bet during Th1 cell differentiation. Thus, unlike NF-κB1, which selectively regulates Th2 cell differentiation, c-Rel is essential for Th1 cell differentiation and Th1 cell–mediated autoimmune inflammation.
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Das, J., Chen, C.-H., Yang, L., Cohn, L., Ray, P., & Ray, A. (2001) · Nature Immunology · doi:10.1038/83158 · Cited by 518
Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis
Campbell, I. K., Gerondakis, S., O’Donnell, K., & Wicks, I. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8298 · Cited by 168
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Barnabei, L., Laplantine, E., Mbongo, W., Rieux-Laucat, F., & Weil, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.716469 · Cited by 630
Single-cell genomics unveils critical regulators of Th17 cell pathogenicity
Gaublomme, J. T., Yosef, N., Lee, Y., Gertner, R. S., Yang, L. V., Wu, C., Pandolfi, P. P., Mak, T., Satija, R., Shalek, A. K., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.009 · Cited by 575
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Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 574
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(2018) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2017.07.007 · Cited by 498
Metadata
- Authors
- Hilliard, B. A., Mason, N., Xu, L., Sun, J., Lamhamedi-Cherradi, S.-E., Liou, H.-C., Hunter, C., & Chen, Y. H.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-09-15
- Volume
- 110
- Issue
- 6
- Pages
- 843-850
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W4243182832
- Cited by
- 181
- References
- 2
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hilliard, B. A., Mason, N., Xu, L., Sun, J., Lamhamedi-Cherradi, S.-E., Liou, H.-C., Hunter, C., & Chen, Y. H. (2002). Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. Journal of Clinical Investigation. https://doi.org/10.1172/jci0215254
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