Cited by 169NF-κB Signaling PathwaysRheumatoid Arthritis Research and TherapiesNatural Compounds in Disease Treatment

Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis

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Campbell, Ian K., Gerondakis, Steve, O’Donnell, Kristy, Wicks, Ian P.·2000·Journal of Clinical Investigation

Abstract

Rheumatoid arthritis (RA) is a complex disease, with contributions from systemic autoimmunity and local inflammation. Persistent synovial joint inflammation and invasive synovial pannus tissue lead to joint destruction. RA is characterized by the production of inflammatory mediators, many of which are regulated by the Rel/NF-kappaB transcription factors. Although an attractive target for therapeutic intervention in inflammatory diseases, Rel/NF-kappaB is involved in normal physiology, thus global inhibition could be harmful. An alternate approach is to identify and target the Rel/NF-kappaB subunits critical for components of disease. To assess this, mice with null mutations in c-rel or nfkb1 were used to examine directly the roles of c-Rel and p50 in models of acute and chronic inflammatory arthritis. We found c-Rel-deficient mice were resistant to collagen-induced arthritis but had a normal response in an acute, destructive arthritis model (methylated BSA/IL-1 induced arthritis) suggesting c-Rel is required for systemic but not local joint disease. In contrast, p50-deficient mice were refractory to induction of both the chronic and acute arthritis models, showing this subunit is essential for local joint inflammation and destruction. Our data suggest Rel/NF-kappaB subunits play distinct roles in the pathogenesis of inflammatory arthritis and may provide a rationale for more specific therapeutic blockade of Rel/NF-kappaB in RA.

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  • The SNP rs260388829 is predicted to disrupt a transcription factor binding site for c-Rel and Sp1.

    “Disruption of TFBS for c-Rel (member of NF-ĸB TF family, linked to CIA development, and lymphoid cell growth and development [86]) and Sp1 (involved in cellular processes including growth, differentiation and apoptosis)”

    From The oncoprotein TBX3 is controlling severity in experimental arthritis (2019) · cites this paper as [86]

    The Introduction identifies c-Rel as a Rel/NF-κB transcription factor and reports that c-Rel-deficient mice largely failed to develop collagen-induced arthritis. It also describes defects in mature B- and T-cell activation, but does not establish a role in lymphoid-cell development. The citation is attached to this description of c-Rel, not to the SNP prediction or the statement about Sp1. (LLM, conf=0.84)

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  1. Campbell, I.K., Hamilton, J.A., and Wicks, I.P. 2000. Collagen-induced arthritis in C57BL/6 (H-2 b ) mice: new insights into an important dis- ease model of rheumatoid arthritis. Eur. J. Immunol. In press.

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Authors
Campbell, I. K., Gerondakis, S., O’Donnell, K., & Wicks, I. P.
Affiliations
  • The Royal Melbourne Hospital (AU)
  • Royal Prince Alfred Hospital (AU)
  • Reid Health (US)
Corresponding author
Wicks, Ian P.
Venue
Journal of Clinical Investigation
Published
2000-06-15
Volume
105
Issue
12
Pages
1799-1806
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2042166751
Cited by
168
References
55
Citations by year
2026: 1 · 2025: 3 · 2024: 7 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 11
FWCI
4.89
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Arthritis Foundation
  • California Institute of Technology
  • Arthritis Foundation of Australia
  • Medical Research Council
  • National Health and Medical Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords
rheumatoid arthritis, c-Rel, collagen-induced arthritis, synovitis, joint destruction, pannus formation, arthritis pathogenesis
MeSH terms
Acute Disease, Animals, Arthritis, Experimental, Chronic Disease, Collagen, Crosses, Genetic, Inflammation, Joints, Mice, Inbred C57BL, Transcription Factors, NF-kappa B, Mice, Knockout, Proto-Oncogene Proteins c-rel, Genes, rel, Mice, NF-kappa B p50 Subunit

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