The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
Open accessAbstract
Matrix metalloproteinases (MMPs) 9 and 2 are increased in human abdominal aortic aneurysm (AAA) tissue, but their precise role and potential interaction remain unclear.Experimental induction of aortic aneurysms in mice genetically deficient in these peptidases could provide new insight into AAA pathogenesis.Mice deficient in the expression of MMP-9 (MMP-9KO) or MMP-2 (MMP-2KO) and their corresponding wild-type background mice (WT) underwent AAA induction by abluminal application of calcium chloride (CaCl 2 ).No aneurysm formation was observed at 10 weeks after treatment in either the MMP-9KO or the MMP-2KO mice, whereas the corresponding WT mice showed an average 74% and 52% increase in aortic diameter, respectively.Reinfusion of competent macrophages from the corresponding WT strains into knockout mice resulted in reconstitution of AAA in MMP-9KO but not MMP-2KO mice.These findings suggest that macrophage-derived MMP-9 and mesenchymal cell MMP-2 are both required and work in concert to produce AAA.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Role of reactive oxygen species in IL-1β-stimulated sustained ERK activation and MMP-9 induction
Gurjar, M. V., Deleon, J., Sharma, R. V., & Bhalla, R. C. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.6.h2568 · Cited by 90
Effects of Noninhibitory α-1-Antitrypsin on Primary Human Monocyte Activation in Vitro
Moraga, F., Lindgren, S., & Janciauskiene, S. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2211 · Cited by 22
Research works printed but not linked: 35
- Alcorn, 1996, Arterioscler Thromb Vasc Biol, 16, 963, 10.1161/01.ATV.16.8.963 · DOI · Paper page
- 10.1056/NEJM199304223281607 · DOI · Paper page
- Pearce, 1996, Ann NY Acad Sci, 800, 175, 10.1111/j.1749-6632.1996.tb33308.x · DOI
- 10.1016/S0967-2109(97)00168-3 · DOI
- Anidjar, 1990, Circulation, 82, 973, 10.1161/01.CIR.82.3.973 · DOI · Paper page
- 10.1172/JCI113368 · DOI
- 10.1016/S0741-5214(96)70274-4 · DOI
- Freestone, 1995, Arterioscler Thromb Vasc Biol, 15, 1145, 10.1161/01.ATV.15.8.1145 · DOI · Paper page
- 10.1172/JCI118037 · DOI · Paper page
- 10.1172/JCI2182 · DOI · Paper page
- Davis, 1998, Arterioscler Thromb Vasc Biol, 18, 1625, 10.1161/01.ATV.18.10.1625 · DOI · Paper page
- 10.1016/S0741-5214(96)70279-3 · DOI · Paper page
- 10.1172/JCI2909 · DOI · Paper page
- 10.1172/JCI8931 · DOI · Paper page
- 10.1074/jbc.272.36.22389 · DOI · Paper page
- Russell, 1972, Arch Pathol, 94, 187
- Goodall, 2001, Circulation, 104, 304, 10.1161/01.CIR.104.3.304 · DOI · Paper page
- 10.1172/JCI8768 · DOI · Paper page
- 10.1038/ni773 · DOI · Paper page
- Hibbs, 1992, Matrix Suppl, 1, 51
- 10.3109/03008209409015042 · DOI
- Rao, 1996, Ann NY Acad Sci, 800, 131, 10.1111/j.1749-6632.1996.tb33304.x · doi:10.1111/j.1749-6632.1996.tb33304.x
- 10.1172/JCI7709 · DOI · Paper page
- Curci, 1999, J Vasc Surg, 29, 385, 10.1016/S0741-5214(99)70393-9 · doi:10.1016/s0741-5214(99)70393-9
- 10.1067/mva.2002.123757 · DOI · Paper page
- Lee, 1995, Arterioscler Thromb Vasc Biol, 15, 2284, 10.1161/01.ATV.15.12.2284 · DOI
- Keen, 1994, J Vasc Surg, 20, 774, 10.1016/S0741-5214(94)70165-2 · DOI
- Galis, 1994, Circ Res, 75, 181, 10.1161/01.RES.75.1.181 · DOI · Paper page
- Newman, 1994, Circulation, 90, 11224
- 10.1089/107999000414853 · DOI
- 10.1172/JCI114867 · DOI · Paper page
- 10.1074/jbc.270.11.5872 · DOI · Paper page
- Dobrin, 1994, Cardiovasc Surg, 2, 484, 10.1177/096721099400200412 · doi:10.1177/096721099400200412
- 10.1038/nm1101-1202 · DOI · Paper page
- Yu, 2000, Genes Dev, 14, 163, 10.1101/gad.14.2.163 · DOI · Paper page
Cited by
Structure and function of matrix metalloproteinases and TIMPs
NAGASE, H., VISSE, R., & MURPHY, G. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.12.002 · Cited by 3,409
Matrix metalloproteinases as modulators of inflammation and innate immunity
Parks, W. C., Wilson, C. L., & López-Boado, Y. S. (2004) · Nature Reviews Immunology · doi:10.1038/nri1418 · Cited by 1,929
The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases
Cabral-Pacheco, G. A., Garza-Veloz, I., Castruita-De la Rosa, C., Ramirez-Acuña, J. M., Perez-Romero, B. A., Guerrero-Rodriguez, J. F., Martinez-Avila, N., & Martinez-Fierro, M. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249739 · Cited by 1,820
Boden, G. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.06.007 · Cited by 853
Newby, A. C. (2005) · Physiological Reviews · doi:10.1152/physrev.00048.2003 · Cited by 817
Metadata
- Authors
- Longo, G. M., Xiong, W., Greiner, T. C., Zhao, Y., Fiotti, N., & Baxter, B. T.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-09-01
- Volume
- 110
- Issue
- 5
- Pages
- 625-632
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W4239965812
- Cited by
- 877
- References
- 2
- FWCI
- 23.47
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms. https://app.cochat.ai/papers/10.1172/jci0215334
- The paper
- Longo, G. M., Xiong, W., Greiner, T. C., Zhao, Y., Fiotti, N., & Baxter, B. T. (2002). Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms. Journal of Clinical Investigation. https://doi.org/10.1172/jci0215334
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
