The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Cystatin C deficiency in human atherosclerosis and aortic aneurysms
Open accessAbstract
The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves breakdown of the elastic laminae. Elastolytic cysteine proteases, including cathepsins S and K, are overexpressed at sites of arterial elastin damage, but whether endogenous local inhibitors counterbalance these proteases is unknown. We show here that, whereas cystatin C is normally expressed in vascular wall smooth muscle cells (SMCs), this cysteine protease inhibitor is severely reduced in both atherosclerotic and aneurysmal aortic lesions. Furthermore, increased abdominal aortic diameter among 122 patients screened by ultrasonography correlated inversely with serum cystatin C levels. In vitro, cytokine-stimulated vascular SMCs secrete cathepsins, whose elastolytic activity could be blocked when cystatin C secretion was induced by treatment with TGF-beta(1). The findings highlight a potentially important role for imbalance between cysteine proteases and cystatin C in arterial wall remodeling and establish that cystatin C deficiency occurs in vascular disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Stability and Instability: Two Faces of Coronary Atherosclerosis: The Paul Dudley White Lecture 1995
Davies, M. J. (1996) · Circulation · doi:10.1161/01.cir.94.8.2013 · Cited by 915
Detection of activated T lymphocytes in the human atherosclerotic plaque.
Hansson, G. K., Holm, J., & Jonasson, L. (1989) · PubMed · Cited by 743
Sukhova, G. K., Shi, G. P., Simon, D. I., Chapman, H. A., & Libby, P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci181 · Cited by 665
Self-citationUrokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
Carmeliet, P., Moons, L., Lijnen, R., Baes, M., Lemaître, V., Tipping, P., Drew, A., Eeckhout, Y., Shapiro, S., Lupu, F., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-439 · Cited by 661
Kyhse-Andersen, J., Schmidt, C., Nordin, G., Andersson, B., Nilsson-Ehle, P., Lindström, V, & Grubb, A. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.10.1921 · Cited by 511
Self-citationAbrahamson, M., Barrett, A. J., Salvesen, G., & Grubb, A. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67380-6 · Cited by 504
Self-citationMacrophages and atherosclerotic plaque stability
Libby, P., Geng, Y. J., Aikawa, M., Schoenbeck, U., Mach, F., Clinton, S. K., Sukhova, G. K., & Lee, R. T. (1996) · Current Opinion in Lipidology · doi:10.1097/00041433-199610000-00012 · Cited by 480
Self-citationThompson, R. W., Holmes, D. R., Mertens, R. A., Liao, S., Botney, M. D., Mecham, R. P., Welgus, H. G., & Parks, W. C. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118037 · Cited by 460
Grainger, D. J., Kemp, P. R., Metcalfe, J. C., Liu, A. C., Lawn, R. M., Williams, N. R., Grace, A. A., Schofield, P. M., & Chauhan, A. (1995) · Nature Medicine · doi:10.1038/nm0195-74 · Cited by 378
Schönbeck, U., Mach, F., Sukhova, G. K., Murphy, C., Bonnefoy, J.-Y., Fabunmi, R. P., & Libby, P. (1997) · Circulation Research · doi:10.1161/01.res.81.3.448 · Cited by 334
Self-citation
Cited by
The lysosome: from waste bag to potential therapeutic target
Appelqvist, H., Wäster, P., Kågedal, K., & Öllinger, K. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt022 · Cited by 772
Abdominal Aortic Aneurysm: Pathogenesis and Implications for Management
Golledge, J., Muller, J., Daugherty, A., & Norman, P. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000245819.32762.cb · Cited by 625
Biochemistry and Clinical Role of Human Cystatin C
Mussap, M., & Plebani, M. (2004) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360490504934 · Cited by 313
Involvement of cystatin C in immunity and apoptosis
Zi, M., & Xu, Y. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.01.006 · Cited by 170
Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis
Taleb, S., Lacasa, D., Bastard, J., Poitou, C., Cancello, R., Pelloux, V., Viguerie, N., Benis, A., Zucker, J., Bouillot, J., et al. (2005) · The FASEB Journal · doi:10.1096/fj.05-3673fje · Cited by 158
Metadata
- Authors
- Shi, G.-P., Sukhova, G. K., Grubb, A., Ducharme, A., Rhode, L. H., Lee, R. T., Ridker, P. M., Libby, P., & Chapman, H. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1999-11-01
- Volume
- 104
- Issue
- 9
- Pages
- 1191-1197
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2134704572
- Cited by
- 455
- References
- 46
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cystatin C deficiency in human atherosclerosis and aortic aneurysms. https://app.cochat.ai/papers/10.1172/jci7709
- The paper
- Shi, G.-P., Sukhova, G. K., Grubb, A., Ducharme, A., Rhode, L. H., Lee, R. T., Ridker, P. M., Libby, P., & Chapman, H. A. (1999). Cystatin C deficiency in human atherosclerosis and aortic aneurysms. Journal of Clinical Investigation. https://doi.org/10.1172/jci7709
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
