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Prodrug-activating systems in suicide gene therapy
Open accessAbstract
Cancer chemotherapy encompasses a large number of well-documented and clinically established methods for the treatment of malignant diseases. However, the efficacy of these approaches is often hampered by an insufficient therapeutic index, lack of specificity, and the emergence of drug-resistant cell subpopulations. One approach aimed at enhancing the selectivity of cancer chemotherapy for solid tumors relies on the application of gene therapy technologies.
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Cited by
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Ettmayer, P., Amidon, G. L., Clement, B., & Testa, B. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm0303812 · Cited by 384
Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities
Sedighi, M., Zahedi Bialvaei, A., Hamblin, M. R., Ohadi, E., Asadi, A., Halajzadeh, M., Lohrasbi, V., Mohammadzadeh, N., Amiriani, T., Krutova, M., et al. (2019) · Cancer Medicine · doi:10.1002/cam4.2148 · Cited by 308
Metadata
- Authors
- Springer, C. J., & Niculescu-Duvaz, I.
- Venue
- Journal of Clinical Investigation
- Published
- 2000-05-01
- Volume
- 105
- Issue
- 9
- Pages
- 1161-1167
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1986902003
- Cited by
- 229
- References
- 0
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Springer, C. J., & Niculescu-Duvaz, I. (2000). Prodrug-activating systems in suicide gene therapy. Journal of Clinical Investigation. https://doi.org/10.1172/jci10001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
