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Cited by 48Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryOphthalmology and Eye Disorders

RELATIONSHIP BETWEEN BLOOD CHOLESTEROL AND INCREASED METABOLISM FROM DINITROPHENOL AND THYROID 1

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Cutting, W. C., Rytand, D. A., Tainter, M. L.·1934·Journal of Clinical Investigation
DOI 10.1172/jci100604PMC PMC436012
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Abstract

It has long been known that certain manifestations of hyperthyroidism follow directly upon the increased metabolic rate, but the causes of other changes in the disease are not so obvious.Dinitrophenol increases metabo- lism by a peripheral action in the tissues, and apparently has no other con- comitant actions in therapeutic doses (1 to 10); thus it is available for studying isolated effects of increased metabolism and determining the im- portance of the latter in thyrotoxicosis.Anxiety, palpitation, and tremor, which are commonly found in hyperthyroidism, are absent when the metabolism is correspondingly increased by dinitrophenol, but increased perspiration and sensations of warmth are present in both (7).The latter symptoms, therefore, are apparently due directly to the heightened metabolism.Another difference from thyroid or thyroxine (6) is absence of accelerated metamorphosis of tadpoles.The heightened metabolism caused by excess thyroid is associated with an in- creased pulse pressure, while that of dinitrophenol is not accompanied by an increased output, as judged from pulse pressure-pulse rate formulae.However, some change in output can be demonstrated in experimental ani- mals with metabolic rates beyond those seen clinically (8).Apparently, with dinitrophenol the tissues get their greater oxygen supply, at least partly, by increased deoxygenation of the blood.In our experience after dinitrophenol, and after dinitro-o-cresol (19), patients with severe degrees of hypothyroidism fail to get symptomatic relief even though the metabolic rate is restored to normal by these drugs.Thus, the ability to increase me- tabolism appears to be the only common action of dinitrophenol and thyroid so far studied.This paper deals with a blood-constituent which is quantitatively modi- fied in thyroid disease, namely, cholesterol.The concentration df blood cholesterol is usually raised in hypothyroidism, and lowered slightly in hyperthyroidism.Therefore, we have studied the changes in cholesterol after dinitrophenol medication to determine whether it varies with the meta- 1 Supported in part by a grant from the Rockefeller Fluid Research Fund of the

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  • Mitochondria are central to the regulation of energy expenditure, and targeting their activity has been a prospect for obesity therapies for decades.

    “Mitochondria are central to the regulation of energy expenditure, and targeting their activity has been a prospect for obesity therapies for decades [47, 48], [49].”

    From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [47]

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  1. Tainter, M. L., Boyes, J. H., and DeEds, F., Actions of dinitrophenol in diabetic dogs. Arch. internat. de pharmacodyn. et de therap., 1933, 45, 235.

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Authors
Cutting, W. C., Rytand, D. A., & Tainter, M. L.
Affiliations
Stanford Medicine (US)
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1934-07-01
Volume
13
Issue
4
Pages
547-552
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci100604
PMC
PMC436012
OpenAlex
W2056764648
Cited by
48
References
19
Citations by year
2019: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 1
FWCI
3.79
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
Keywords
serum cholesterol, dinitrophenol, hyperthyroidism, hypothyroidism, thyrotoxicosis, thyroid dysfunction, dinitro-o-cresol, pulse pressure, oxygen supply

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