The effects of antimicrobial agents upon choline degradation in the intestinal tract
Open accessAbstract
A variety of intestinal bacteria have been shown to be capable of degrading choline to trimethylamine (1-3) which is readily absorbed from the intestine and excreted in the urine mainly as trimethylamine
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Even in the absence of dietary sources of methylamines, baseline levels of TMA and TMAO are found in the circulation.
“even in the absence of dietary sources of methylamines, baseline levels of TMA and TMAO are found in the circulation (De La Huerga et al., 1953;Hoyles et al., 2018b).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as De La Huerga et al., 1953
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
de la Huerga, J., & Popper, H. (1951) · Journal of Clinical Investigation · doi:10.1172/jci102463 · Cited by 129 · see citing works
Cortisone, Acth and Antibiotics in Fulminant Hepatitis
Ducci, H., & Katz, R. (1952) · Gastroenterology · doi:10.1016/s0016-5085(52)80035-6 · Cited by 87 · see citing works
STUDIES ON THE USE OF AUREOMYCIN IN HEPATIC DISEASE
Farquhar, J. D., Stokes, J., Whitlock, C. M., Bluemle, L. W., & Gambescia, J. M. (1950) · The American Journal of the Medical Sciences · doi:10.1097/00000441-195008000-00007 · Cited by 50 · see citing works
STUDIES ON THE USE OF AUREOMYCIN IN HEPATIC DISEASE°
György, P., Stokes, J., Smith, W. H., & Goldblatt, H. (1950) · The American Journal of the Medical Sciences · doi:10.1097/00000441-195007000-00002 · Cited by 48 · see citing works
FACTORS INFLUENCING CHOLINE ABSORPTION IN THE INTESTINAL TRACT 1
de la Huerga, J., & Pópper, H. (1952) · Journal of Clinical Investigation · doi:10.1172/jci102646 · Cited by 42 · see citing works
ANTIMICROBIAL AGENTS IN THE PREVENTION OF DIETARY HEPATIC INJURY (NECROSIS, CIRRHOSIS) IN RATS
György, P., Stokes, J., Goldblatt, H., & Pópper, H. (1951) · The Journal of Experimental Medicine · doi:10.1084/jem.93.6.513 · Cited by 39 · see citing works
Action of Enterobacteriaceae on Choline and Related Compounds
Dyer, F. E., & Wood, A. J. (1947) · Journal of the Fisheries Research Board of Canada · doi:10.1139/f47-002 · Cited by 29 · see citing works
The Excretion and Concentration of Aureomycin the Abnormal Human Biliary Tract
Zaslow, J., Hewlett, T. H., & Goldsmith, R. S. (1950) · Gastroenterology · doi:10.1016/s0016-5085(19)36573-4 · Cited by 12 · see citing works
Effects of Aureomycin on Renal Lesions, Liver Lipid, and Tissue Choline in Choline Deficiency
Baxter, J. H., & Campbell, H. (1952) · Experimental Biology and Medicine · doi:10.3181/00379727-80-19641 · Cited by 11 · see citing works
Antimicrobial agents in the prevention of experimental dietary injury of the liver.
György, P., STOKES, J., & Goldblatt, H. (1951) · PubMed · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Cohen, G. N., Nisman, B., and Raynaud, M., Sur la degradation bacterienne de la choline et de la colamine. Compt. rend. Acad. d. sc., 1947, 225, 647.
- Zaslow, J., Hewlett, T. H., and Goldsmith, R., The excretion and concentration of aureomycin in the abnormal human biliary tract. Part II. Hepatic bile. Gastroenterology, 1950, 16, 479.
Cited by
Sorted by citations
Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319 · see citing works
Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota
Hoyles, L., Jiménez-Pranteda, M. L., Chilloux, J., Brial, F., Myridakis, A., Aranias, T., Magnan, C., Gibson, G. R., Sanderson, J. D., Nicholson, J. K., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0461-0 · Cited by 251 · see citing works
Normal Bacterial Populations of the Intestine and Their Relation to Intestinal Function
Donaldson, R. M. (1964) · New England Journal of Medicine · doi:10.1056/nejm196405142702007 · Cited by 207 · see citing works
Hepatic effects of jejunoileal bypass for morbid obesity
Brown, R. G., O’Leary, J. P., & Woodward, E. R. (1974) · The American Journal of Surgery · doi:10.1016/0002-9610(74)90011-7 · Cited by 120 · see citing works
The origin of urinary dimethylamine
Asatoor, A. M., & Simeshoff, M. L. (1965) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(65)90048-6 · Cited by 107 · see citing works
Bioavailability of choline and choline esters from milk in rat pups
Cheng, W.-L., Holmes-McNary, M. Q., Mar, M.-H. H., Lien, E. L., & Zeisel, S. H. (1996) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(96)00079-4 · Cited by 73 · see citing works
Intestinal Synthesis of Vitamins in the Nonruminant
Mickelsen, O. (1956) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60298-8 · Cited by 71 · see citing works
ACID‐BASE IN RENAL FAILURE: New Perspectives on Acid‐Base Balance
Oh, M. S. (2000) · Seminars in Dialysis · doi:10.1046/j.1525-139x.2000.00061.x · Cited by 42 · see citing works
The metabolism of choline by the germfree rat
Prentiss, P. G., Rosen, H., Brown, N. D., Horowitz, R. E., Malm, O. J., & Levenson, S. Μ. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90069-8 · Cited by 38 · see citing works
Normal Bacterial Populations of the Intestine and Their Relation to Intestinal Function
Donaldson, R. M. (1964) · New England Journal of Medicine · doi:10.1056/nejm196405072701907 · Cited by 34 · see citing works
Fatty livers and lipotropic phenomena
Lucas, C. C., & Ridout, J. H. (1970) · Progress in the Chemistry of Fats and other Lipids · doi:10.1016/0079-6832(70)90004-2 · Cited by 33 · see citing works
Influence of the Human Gut Microbiome on the Metabolic Phenotype
Hoyles, L., & Swann, J. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812293-8.00018-9 · Cited by 21 · see citing works
Importance of Choline During Growth, with Particular Reference to Synthetic Diets in Phenylketonuria
Wilson, K. M., & Clayton, B. E. (1962) · Archives of Disease in Childhood · doi:10.1136/adc.37.196.565 · Cited by 20 · see citing works
Levenson, S. Μ., Nagler, A. L., Geever, E. F., & Seifter, E. (1968) · Journal of Nutrition · doi:10.1093/jn/95.2.247 · Cited by 16 · see citing works
URINARY EXCRETION OF METHYLMALONIC, α, α-DIMETHYLSUCCINIC, AND OTHER ETHER-SOLUBLE ACIDS IN RATS
Barness, L. A., Moeksi, H., & György, P. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65231-7 · Cited by 15 · see citing works
Choline, Methionine and Sulphate Interrelationships in Poultry Nutrition—A Review
Ruiz, N. C., MILES, R. D., & Harms, R. H. (1983) · World s Poultry Science Journal · doi:10.1079/wps19830017 · Cited by 14 · see citing works
External Balance of Electrolytes and Acids and Alkali
Oh, M. S. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381462-3.00010-0 · Cited by 8 · see citing works
ON SOME ASPECTS OF PROTEIN NUTRITION
György, P. (1954) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/2.4.231 · Cited by 8 · see citing works
Liver Enzyme Elevation associated with Total Parenteral Nutrition
Greenlaw, C. W. (1980) · Annals of Pharmacotherapy · doi:10.1177/106002808001401008 · Cited by 7 · see citing works
Effect of Coprophagy Prevention and Antibiotics on Choline Degradation in Rats
Kwong, E., & Barnes, R. H. (1970) · Journal of Nutrition · doi:10.1093/jn/100.7.711 · Cited by 5 · see citing works
Goh, Y. K., SHIRES, A., Robblee, A. R., & Clandinin, D. R. (1982) · Canadian Journal of Animal Science · doi:10.4141/cjas82-111 · Cited by 4 · see citing works
Genetic and dietary interactions of fishy-egg taint in brown-shelled laying hens
Ward, A. K. K. (2008) · University Library - University of Saskatchewan (University of Saskatchewan) · Cited by 2 · see citing works
On the Role of Antibiotics in Nutrition and Metabolism
GYOÖRGY, P. (1958) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/6.5.466 · Cited by 1 · see citing works
External Balance of Electrolytes and Acids and Alkali
Oh, M. S., & Carroll, H. J. (2008) · Elsevier eBooks · doi:10.1016/b978-012088488-9.50013-9 · Cited by 1 · see citing works
Baerle, R. R.-V. (1958) · Springer eBooks · doi:10.1007/978-3-642-86611-1_18
- Authors
- De La Huerga, J., György, P., Waldstein, S., Katz, R., & Popper, H.
- Affiliations
- Northwestern University (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1953-11-01
- Volume
- 32
- Issue
- 11
- Pages
- 1117-1120
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC438450
- OpenAlex
- W2062226501
- Cited by
- 25
- References
- 10
- Citations by year
- 2019: 1 · 2018: 2 · 2012: 1
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- antimicrobial agents, trimethylamine, intestinal bacteria, trimethylamine N-oxide, gut microbiota
- MeSH terms
- Anti-Infective Agents, Anti-Bacterial Agents, Choline, Dermatologic Agents, Humans, Intestinal Mucosa
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
