URINARY EXCRETION OF CHOLINE METABOLITES FOLLOWING CHOLINE ADMINISTRATION IN NORMALS AND PATIENTS WITH HEPATOBILIARY DISEASES 1
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Gut microbial metabolism of choline results in the production of trimethylamine (TMA).
“Previous studies have established that gut microbial metabolism of choline results in the production of trimethylamine (TMA) (12–14).”
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Research works printed but not linked: 13
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- Folin, O., and Ciocalteu, V., On tyrosine and trypto- phane determinations in proteins. J. Biol. Chem., 1927, 73, 627.
- Glick, D., Concerning the reineckate method for the determination of choline. J. Biol. Chem., 1944, 156, 643.
- Kapfhammer, J., and Bischoff, C., Acetylcholin und Cholin aus tierischen Organen. I. Darstellung aus Rinderblut. Ztschr. f. physiol. Chem., 1930, 191, 179.
- Sobel, A. E., Mayer, A. M., and Gottfried, S. P., A convenient titrimetric ultramicromethod for the estimation of urea and Kjeldahl nitrogen. J. Biol. Chem., 1944, 156, 355.
- Dyer, W. J., Amines in fish muscle: I. Colorimetric determination of trimethylamine as the picrate salt. J. Fisheries Research Board, Canada, 1945, 6, 351.
- Norris, E. R., and Benoit, G. J., Jr., Studies on tri- methylamine oxide. I. Occurrence of trimethyl- amine oxide in marine organisms. J. Biol. Chem., 1945, 158, 433.
- Dyer, F. E., and Wood, A. J., Action of Enterobac- teriaceae on choline and related compounds. J. Fisheries Research Board, Canada, 1947, 7, 17.
- Norris, E. R., and Benoit, G. J., Jr., Studies on tri- methylamine oxide. III. Trimethylamine oxide excretion by the rat. J. Biol. Chem., 1945, 158, 443.
- Lintzel, W., Untersuchungen uber Trimethylam- moniumbasen. III. Trimethylammoniumbasen im menschlichen Harn. Biochem. Ztschr., 1934, 273, 243.
- Muller, H., Uber den Cholinstoffwechsel. I. Mit- teilung. Ztschr. f. physiol. Chem., 1940, 226, 205.
- Cayer, D., and Cornatzer, W. E., The effects of lipo- tropic substances on phospholipide synthesis in pa- tients with and without chronic hepatitis as meas- ured by radioactive phosphorus. Southern Med. J., 1949, 42, 669.
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- Authors
- de la Huerga, J., & Popper, H.
- Venue
- Journal of Clinical Investigation
- Published
- 1951-05-01
- Volume
- 30
- Issue
- 5
- Pages
- 463-470
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC436280
- OpenAlex
- W2041432787
- Cited by
- 129
- References
- 0
- Citations by year
- 2026: 2 · 2021: 2 · 2020: 3 · 2019: 7 · 2018: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 4
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Keywords
- choline metabolism, urinary excretion, hepatobiliary diseases, liver disease, choline metabolites
- MeSH terms
- Biliary Tract, Choline, Pharmaceutical Preparations, Gastrointestinal Diseases, Humans, Liver, Chemical and Drug Induced Liver Injury
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