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THE RENAL CLEARANCE OF ALKALI-STABLE INULIN
Open accessAbstract
Commercial inulin available at present is not a homogeneous product (1). It consists of two major fractions the proportions of which vary: (a) a portion of relatively large molecular weight resistant to heating in alkali; and (b) a portion of smaller molecular weight susceptible to destruc-tion with alkali. In addition, most samples con-tain a small percentage of fructose, which also yields color in the analytical methods for inulin unless removed by treatment with yeast or hot alkali. Two recent reports (2, 3) indicate that the clearance of the alkali-stable and alkali-labile frac-tions of inulin may not be equal. Since some com-mercial preparations of inulin (such as the one used in this study) may contain as much as 50 per cent of the alkali-labile material, considerable errors in estimation of glomerular filtration rate would occur if a difference in clearance of the two fractions exists. The present report indicates that the clearance of the two fractions is identical, within the limits of error of analysis, in confirmation of the prelimi-nary report by Cotlove (1).
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Cited by
The Renin–Angiotensin–Aldosterone System and Autosomal Dominant Polycystic Kidney Disease
Chapman, A. B., Johnson, A., Gabow, P. A., & Schrier, R. W. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010183231602 · Cited by 398
Impact of gender on the renal response to angiotensin II
Miller, J. A., Anacta, L. A., & Cattran, D. C. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00260.x · Cited by 255
Chapman, A. B., Zamudio, S., Woodmansee, W., Merouani, A., Osorio, F., Johnson, A., Moore, L. G., Dahms, T., Coffin, C., Abraham, W. T., et al. (1997) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1997.273.5.f777 · Cited by 201
Effect of Fenofibrate on Kidney Function: A 6-Week Randomized Crossover Trial in Healthy People
Ansquer, J.-C., Dalton, R. N., Caussé, E., Crimet, D., Le Malicot, K., & Foucher, C. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.01.014 · Cited by 107
Effect of oral contraceptives on the renin angiotensin system and renal function
Kang, A. K., Duncan, J. A., Cattran, D. C., Floras, J. S., Lai, V., Scholey, J. W., & Miller, J. A. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.3.r807 · Cited by 103
Metadata
- Authors
- Walser, M., Davidson, D. G., & Orloff, J.
- Venue
- Journal of Clinical Investigation
- Published
- 1955-10-01
- Volume
- 34
- Issue
- 10
- Pages
- 1520-1523
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2000486229
- Cited by
- 395
- References
- 0
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: THE RENAL CLEARANCE OF ALKALI-STABLE INULIN. https://app.cochat.ai/papers/10.1172/jci103204
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- Walser, M., Davidson, D. G., & Orloff, J. (1955). THE RENAL CLEARANCE OF ALKALI-STABLE INULIN. Journal of Clinical Investigation. https://doi.org/10.1172/jci103204
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
