Cited by 300Traumatic Brain Injury and Neurovascular DisturbancesAdvanced MRI Techniques and ApplicationsBiomedical and Chemical Research

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An Adaptation of the Nitrous Oxide Method to the Study of the Cerebral Circulation in Children; Normal Values for Cerebral Blood Flow and Cerebral Metabolic Rate in Childhood1

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Kennedy, Charles, Sokoloff, Louis·1957·Journal of Clinical Investigation

DOI 10.1172/jci103509PMC PMC1072700

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THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES 1
Kety, S. S., & Schmidt, C. F. (1948) · Journal of Clinical Investigation · doi:10.1172/jci101994 · Cited by 2,058
THE DETERMINATION OF GASES IN BLOOD AND OTHER SOLUTIONS BY VACUUM EXTRACTION AND MANOMETRIC MEASUREMENT. I
Slyke, D. D. V., & Neill, J. M. (1924) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)85145-6 · Cited by 2,007
THE EFFECTS OF ALTERED ARTERIAL TENSIONS OF CARBON DIOXIDE AND OXYGEN ON CEREBRAL BLOOD FLOW AND CEREBRAL OXYGEN CONSUMPTION OF NORMAL YOUNG MEN 1
Kety, S. S., & Schmidt, C. F. (1948) · Journal of Clinical Investigation · doi:10.1172/jci101995 · Cited by 1,827 · cited 2×
“despite a slight increase in cerebral blood flow (8), the latter change probably a secondary effect of respiratory depression and consequent elevation of blood carbon dioxide tension (9).”
Background
Quantitative Clinical Chemistry
Peters, J. P., & Slyke, D. D. V. (1932) · American Journal of Clinical Pathology · doi:10.1093/ajcp/2.6.492 · Cited by 1,580
SPECTROPHOTOMETRIC STUDIES
Drabkin, D. L., & Austin, J. H. (1935) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)74965-x · Cited by 1,018
Quantitative Clinical Chemistry.
(1932) · Archives of Internal Medicine · doi:10.1001/archinte.1932.00150140175014 · Cited by 838
THE EFFECT OF TEMPERATURE ON THE pH OF BLOOD AND PLASMA IN VITRO
Rosenthal, T. B. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35552-2 · Cited by 587
THE CEREBRAL BLOOD FLOW IN MALE SUBJECTS AS MEASURED BY THE NITROUS OXIDE TECHNIQUE. NORMAL VALUES FOR BLOOD FLOW, OXYGEN UTILIZATION, GLUCOSE UTILIZATION, AND PERIPHERAL RESISTANCE, WITH OBSERVATIONS ON THE EFFECT OF TILTING AND ANXIETY 1
Scheinberg, P., & Stead, E. A. (1949) · Journal of Clinical Investigation · doi:10.1172/jci102150 · Cited by 363
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Slyke, D. D. V. (1925) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)84758-5 · Cited by 326
Circulation and metabolism of the human brain in health and disease
Kety, S. S. (1950) · The American Journal of Medicine · doi:10.1016/0002-9343(50)90363-9 · Cited by 281

Show all 35 references

Research works printed but not linked: 6

Stroud, M. W., Lambertsen, C. J., Wendel, H., and Daley, M. deB., Comparison of continuous and intermittent sampling in nitrous oxide method for determining cerebral blood flow. Federation Proc., 1954, 13, 147.
Kennedy, C., A micro method for the determination of nitrous oxide in blood. J. Applied Physiol., In press.
Gibbs, E. L., Lennox, W. G., and Gibbs, F. A., Bi- lateral internal jugular blood. Comparison of A-V differences, oxygen-dextrose ratios and re- spiratory quotients. Am. J. Psychiat., 1945, 102, 184.
Kety, S. S., Changes in cerebral circulation and oxy- gen consumption which accompany maturation and aging in International Neurochemical Symposium, 1st, Magdalen College, Oxford, 1954, Biochem- istry of the Developing Nervous System. New York, Academic Press, 1955, p. 208.
Schmidt, C. F., and Hendrix, J. P., The action of chemical substances on cerebral blood-vessels. A. Research Nerv. & Ment. Dis., Proc., 1937, 18, 229.
White House Conference on Child Health and Pro- tection. Sect I. Medical Service Committee on Growth and Development. Growth and Develop- ment of the Child. Part II. Anatomy and Physi- ology. New York, Century Press, 1933, p. 180.

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Authors: Kennedy, C., & Sokoloff, L.
Affiliations: Children's Hospital of Philadelphia (US)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1957-07-01
Volume: 36
Issue: 7
Pages: 1130-1137
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci103509
PMC: PMC1072700
OpenAlex: W2144097932
Cited by: 300
References: 35
Citations by year: 2026: 2 · 2025: 4 · 2024: 7 · 2023: 2 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 9 · 2018: 10 · 2017: 13 · 2016: 9 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 11
FWCI: 4.26
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Physiology (medical) › Biomedical and Chemical Research
Keywords: cerebral blood flow, cerebral metabolic rate, children, reference values, cerebral circulation, pediatric neurophysiology
MeSH terms: Acclimatization, Brain, Cerebrovascular Circulation, Child, Humans, Nitrous Oxide, Reference Values

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An Adaptation of the Nitrous Oxide Method to the Study of the Cerebral Circulation in Children; Normal Values for Cerebral Blood Flow and Cerebral Metabolic Rate in Childhood1

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