Cited by 300Traumatic Brain Injury and Neurovascular DisturbancesAdvanced MRI Techniques and ApplicationsBiomedical and Chemical Research

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An Adaptation of the Nitrous Oxide Method to the Study of the Cerebral Circulation in Children; Normal Values for Cerebral Blood Flow and Cerebral Metabolic Rate in Childhood1

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Kennedy, Charles, Sokoloff, Louis·1957·Journal of Clinical Investigation

DOI 10.1172/jci103509PMC PMC1072700

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THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES 1
Kety, S. S., & Schmidt, C. F. (1948) · Journal of Clinical Investigation · doi:10.1172/jci101994 · Cited by 2,058
THE DETERMINATION OF GASES IN BLOOD AND OTHER SOLUTIONS BY VACUUM EXTRACTION AND MANOMETRIC MEASUREMENT. I
Slyke, D. D. V., & Neill, J. M. (1924) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)85145-6 · Cited by 2,007
THE EFFECTS OF ALTERED ARTERIAL TENSIONS OF CARBON DIOXIDE AND OXYGEN ON CEREBRAL BLOOD FLOW AND CEREBRAL OXYGEN CONSUMPTION OF NORMAL YOUNG MEN 1
Kety, S. S., & Schmidt, C. F. (1948) · Journal of Clinical Investigation · doi:10.1172/jci101995 · Cited by 1,827 · cited 2×
“despite a slight increase in cerebral blood flow (8), the latter change probably a secondary effect of respiratory depression and consequent elevation of blood carbon dioxide tension (9).”
Background
Quantitative Clinical Chemistry
Peters, J. P., & Slyke, D. D. V. (1932) · American Journal of Clinical Pathology · doi:10.1093/ajcp/2.6.492 · Cited by 1,580
SPECTROPHOTOMETRIC STUDIES
Drabkin, D. L., & Austin, J. H. (1935) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)74965-x · Cited by 1,018
Quantitative Clinical Chemistry.
(1932) · Archives of Internal Medicine · doi:10.1001/archinte.1932.00150140175014 · Cited by 838
THE EFFECT OF TEMPERATURE ON THE pH OF BLOOD AND PLASMA IN VITRO
Rosenthal, T. B. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35552-2 · Cited by 587
THE CEREBRAL BLOOD FLOW IN MALE SUBJECTS AS MEASURED BY THE NITROUS OXIDE TECHNIQUE. NORMAL VALUES FOR BLOOD FLOW, OXYGEN UTILIZATION, GLUCOSE UTILIZATION, AND PERIPHERAL RESISTANCE, WITH OBSERVATIONS ON THE EFFECT OF TILTING AND ANXIETY 1
Scheinberg, P., & Stead, E. A. (1949) · Journal of Clinical Investigation · doi:10.1172/jci102150 · Cited by 363
THE DETERMINATION OF GASES IN BLOOD AND OTHER SOLUTIONS BY VACUUM EXTRACTION AND MANOMETRIC MEASUREMENT
Slyke, D. D. V. (1925) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)84758-5 · Cited by 326
Circulation and metabolism of the human brain in health and disease
Kety, S. S. (1950) · The American Journal of Medicine · doi:10.1016/0002-9343(50)90363-9 · Cited by 281

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Research works printed but not linked: 6

Stroud, M. W., Lambertsen, C. J., Wendel, H., and Daley, M. deB., Comparison of continuous and intermittent sampling in nitrous oxide method for determining cerebral blood flow. Federation Proc., 1954, 13, 147.
Kennedy, C., A micro method for the determination of nitrous oxide in blood. J. Applied Physiol., In press.
Gibbs, E. L., Lennox, W. G., and Gibbs, F. A., Bi- lateral internal jugular blood. Comparison of A-V differences, oxygen-dextrose ratios and re- spiratory quotients. Am. J. Psychiat., 1945, 102, 184.
Kety, S. S., Changes in cerebral circulation and oxy- gen consumption which accompany maturation and aging in International Neurochemical Symposium, 1st, Magdalen College, Oxford, 1954, Biochem- istry of the Developing Nervous System. New York, Academic Press, 1955, p. 208.
Schmidt, C. F., and Hendrix, J. P., The action of chemical substances on cerebral blood-vessels. A. Research Nerv. & Ment. Dis., Proc., 1937, 18, 229.
White House Conference on Child Health and Pro- tection. Sect I. Medical Service Committee on Growth and Development. Growth and Develop- ment of the Child. Part II. Anatomy and Physi- ology. New York, Century Press, 1933, p. 180.

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Regional cerebral blood flow with age: changes in rCBF in childhood
Ogawa, A., Sakurai, Y., Kayama, T., & Yoshimoto, T. (1989) · Neurological Research · doi:10.1080/01616412.1989.11739886 · Cited by 53
An estimation of intracranial blood flow in the new‐born infant.
Cross, K. W., Dear, P. R., Hathorn, M. K. S., Hyams, A., Kerslake, D. M., Milligan, D. W. A., Rahilly, P. M., & Stothers, J. K. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012740 · Cited by 52
Metabolism as a tool for understanding human brain evolution: Lipid energy metabolism as an example
Wang, S. P., Yang, H., Wu, J. W., Gauthier, N., Fukao, T., & Mitchell, G. A. (2014) · Journal of Human Evolution · doi:10.1016/j.jhevol.2014.06.013 · Cited by 50
Effects of ketosis on glucose flux in children and adults
Haymond, M. W., Howard, C., Ben-Galim, E., & DeVivo, D. C. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.245.4.e373 · Cited by 51
Anaesthesia for neurosurgical procedures in paediatric patients
Rath, G. P., & Dash, H. (2012) · Indian Journal of Anaesthesia · doi:10.4103/0019-5049.103979 · Cited by 50
Eating breakfast enhances the efficiency of neural networks engaged during mental arithmetic in school-aged children
Pivik, R. T., Tennal, K. B., Chapman, S. D., & Gu, Y. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.03.034 · Cited by 48
Cerebral Energy Metabolism
Hawkins, R. A. (1985) · Springer eBooks · doi:10.1007/978-1-4684-1209-3_1 · Cited by 50
Structural and Functional Imaging Correlates for Age-Related Changes in the Brain
Tumeh, P. C., Alavi, A. A., Houseni, M., Greenfield, A. L., Chryssikos, T. J., Newberg, A. B., Torigian, D. A., & Moonis, G. (2007) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2006.10.002 · Cited by 51
FDG PET of the Brain in Pediatric Patients: Imaging Spectrum with MR Imaging Correlation
Stanescu, L. A., Ishak, G. E., Khanna, P. C., Biyyam, D. R., Shaw, D., & Parisi, M. T. (2013) · Radiographics · doi:10.1148/rg.335125152 · Cited by 48
Noninvasive Method of Estimating Human Newborn Regional Cerebral Blood Flow
Younkin, D. P., Reivich, M., Jaggi, J. L., Obrist, W. D., & Delivoria‐Papadopoulos, M. (1982) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1982.47 · Cited by 48
Autoradiographic measurement of local cerebral β-hydroxybutyrate uptake in the rat during postnatal development
Nehlig, A., Boyet, S., & de Vasconcelos, A. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90018-j · Cited by 47
Cerebral autoregulation in children during sevoflurane anaesthesia † ‡This work was presented, in part, as an abstract at the Society of Neurological Anesthesia and Critical Care Society Meeting, 13 October 2000, in San Francisco, CA.
Vavilala, M. S., Lee, L. A., Lee, M., Graham, A., Visco, E., & Lam, A. M. (2003) · British Journal of Anaesthesia · doi:10.1093/bja/aeg119 · Cited by 47
Comparison of Cerebrovascular Response to Hypoxic and Carbon Monoxide Hypoxia in Newborn and Adult Sheep
Koehler, R. C., Traystman, R. J., Zeger, S. L., Rogers, M. C., & Jones, M. (1984) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1984.16 · Cited by 47
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Zhu, Y., Verkhratsky, A., Chen, H., & Yi, C. (2025) · Acta Physiologica · doi:10.1111/apha.14283 · Cited by 51
Untitled work
(1986) · doi:10.1007/978-1-4899-0522-2_5 · Cited by 74
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Nielsen, J. B., Friberg, L., LOU, H. C., Lassen, N. A., & Sam, I. L. K. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530090054013 · Cited by 45
Hemodynamics and Metabolism in Ischemic Cerebrovascular Disease
Powers, W. J. (1992) · Neurologic Clinics · doi:10.1016/s0733-8619(18)30232-9 · Cited by 45

Authors: Kennedy, C., & Sokoloff, L.
Affiliations: Children's Hospital of Philadelphia (US)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1957-07-01
Volume: 36
Issue: 7
Pages: 1130-1137
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci103509
PMC: PMC1072700
OpenAlex: W2144097932
Cited by: 300
References: 35
Citations by year: 2026: 2 · 2025: 4 · 2024: 7 · 2023: 2 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 9 · 2018: 10 · 2017: 13 · 2016: 9 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 11
FWCI: 4.26
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Physiology (medical) › Biomedical and Chemical Research
Keywords: cerebral blood flow, cerebral metabolic rate, children, reference values, cerebral circulation, pediatric neurophysiology
MeSH terms: Acclimatization, Brain, Cerebrovascular Circulation, Child, Humans, Nitrous Oxide, Reference Values

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An Adaptation of the Nitrous Oxide Method to the Study of the Cerebral Circulation in Children; Normal Values for Cerebral Blood Flow and Cerebral Metabolic Rate in Childhood1

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