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Cited by 394Cardiovascular and exercise physiologyExercise and Physiological ResponsesThermoregulation and physiological responses

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Indocyanine Green Clearance and Estimated Hepatic Blood Flow during Mild to Maximal Exercise in Upright Man *

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Rowell, Loring B., Blackmon, John R., Bruce, Robert A.·1964·Journal of Clinical Investigation
DOI 10.1172/jci105043PMC PMC441967
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Abstract

Krogh in 1912 (1) postulated the necessity for a large capacity venous reservoir capable of quickly delivering an autotransfusion of blood into the right heart during exercise, particularly in upright man, where Krogh felt venous return may at times be inadequate.Bock and co-workers (2) in their classical work reasoned that increased blood flow to working muscle, related in part to local vasodilation, must be partially effected by de- creased splanchnic blood flow.Since the splanch- nic region receives 20 to 25% of the total left ven- tricular output but extracts only 10 to 25% of the available oxygen (3), the splanchnic bed is ideally suited for rapid correction for any residual in- balance between left ventricular output and peripheral distribution of flow.The experimental evaluation of the influence of exercise on splanchnic blood flow, however, has produced conflicting results.Herrick, Grindlay, Baldes, and Mann (4), and more recently Rush- mer, Franklin, Van Citters, and Smith (5) did not find a decrease in splanchnic blood flow in dogs undergoing an intensity of exercise far below their maximal capacities.Also plethysmographic studies in man by Sj6strand (6) led him to con- clude that intrathoracic rather than splanchnic blood depots are functionally important in exer- cise.In contrast, a study by Bradley (7) and by Wade and co-workers (8), utilizing the sulfo- bromophthalein sodium (BSP) extraction method, demonstrated that significant decreases in splanch-

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Research works printed but not linked: 9

  1. Krogh, A. The regulation of the supply of blood to the right heart. Skand. Arch. Physiol. 1912, 27, 227.
  2. Bock, A. V., C. Vancaulaert, D. B. Dill, A. F6lling, and L. M. Hurxthal. Studies in muscular ac- tivity. III. Dynamical changes occurring in man at work. J. Physiol. (Lond.) 1928, 66, 136.
  3. Bradley, S. E. Hepatic blood flow. Effect of pos- ture and exercise upon blood flow through the liver in Transactions of the Seventh Conference on Liver Injury. New York, Josiah Macy, Jr., Foun- dation, 1948, p. 53.
  4. Bruce, R. A., J. R. Blackmon, J. W. Jones, and G. Strait. Exercise testing in adult normal sub- jects and cardiac patients. Pediatrics supply.) 1963, 32, 742.
  5. Gregersen, M. I. Blood volume, hemorrhage, and shock in Medical Physiology, 11th ed., P. Bard, Ed. St. Louis, C. V. Mosby, 1961, p. 280.
  6. Bradley, S. E. Liver function as studied by hepatic vein catheterization in Transactions of the Fifth Conference on Liver Injury. New York, Josiah Macy, Jr., Foundation, 1946, p. 38.
  7. Cassels, D. E., and M. Morse. Blood volume anl ex- ercise. J. Pediat. 1942, 20, 352.
  8. Knisely, M. H., F. Harding, and H. Debacker. He- patic sphincters, brief summary of present-day knowledge. Science 1957, 125, 1023.
  9. Wang, Y., J. T. Shepherd, R. J. Marshall, L. Rowell, and H. L. Taylor. Cardiac response to exercise in unconditioned young men and in athletes (abstract). Circulation 1961, 24, 1064.

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Metadata

Authors
Rowell, L. B., Blackmon, J. R., & Bruce, R. A.
Affiliations
University of Washington (US)
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1964-08-01
Volume
43
Issue
8
Pages
1677-1690
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci105043
PMC
PMC441967
OpenAlex
W2112073163
Cited by
394
References
34
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 10 · 2013: 11 · 2012: 9
FWCI
7.29
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Washington State University
Topics
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
Keywords
indocyanine green clearance, hepatic blood flow, physical activity, splanchnic circulation, venous return, autologous blood transfusion, upright posture, venous reservoir
MeSH terms
Blood Volume, Coloring Agents, Physical Exertion, Hemodynamics, Humans, Indocyanine Green, Liver, Liver Circulation, Liver Function Tests, Male, Metabolism, Rest, Urine

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