The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Indocyanine Green Clearance and Estimated Hepatic Blood Flow during Mild to Maximal Exercise in Upright Man *
Open accessAbstract
Krogh in 1912 (1) postulated the necessity for a large capacity venous reservoir capable of quickly delivering an autotransfusion of blood into the right heart during exercise, particularly in upright man, where Krogh felt venous return may at times be inadequate.Bock and co-workers (2) in their classical work reasoned that increased blood flow to working muscle, related in part to local vasodilation, must be partially effected by de- creased splanchnic blood flow.Since the splanch- nic region receives 20 to 25% of the total left ven- tricular output but extracts only 10 to 25% of the available oxygen (3), the splanchnic bed is ideally suited for rapid correction for any residual in- balance between left ventricular output and peripheral distribution of flow.The experimental evaluation of the influence of exercise on splanchnic blood flow, however, has produced conflicting results.Herrick, Grindlay, Baldes, and Mann (4), and more recently Rush- mer, Franklin, Van Citters, and Smith (5) did not find a decrease in splanchnic blood flow in dogs undergoing an intensity of exercise far below their maximal capacities.Also plethysmographic studies in man by Sj6strand (6) led him to con- clude that intrathoracic rather than splanchnic blood depots are functionally important in exer- cise.In contrast, a study by Bradley (7) and by Wade and co-workers (8), utilizing the sulfo- bromophthalein sodium (BSP) extraction method, demonstrated that significant decreases in splanch-
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“The pathophysiology of GI distress during ultra-marathon training and racing is multifactorial, but is likely the result of reduced mesenteric blood flow [131, 132], leading to relative GI hypoperfusion [133].”
From International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing (2019) · cites this paper as [131]
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“The pathophysiology of GI distress during ultra-marathon training and racing is multifactorial, but is likely the result of reduced mesenteric blood flow [131, 132], leading to relative GI hypoperfusion [133].”
From International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing (2019) · cites this paper as [131]
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Citations
Cites
Maximal Oxygen Intake as an Objective Measure of Cardio-Respiratory Performance
TAYLOR, H. L., BUSKIRK, E. R., & Henschel, A. F. (1955) · Journal of Applied Physiology · doi:10.1152/jappl.1955.8.1.73 · Cited by 1,366
INDOCYANINE GREEN: OBSERVATIONS ON ITS PHYSICAL PROPERTIES, PLASMA DECAY, AND HEPATIC EXTRACTION*
Cherrick, G. R., Stein, S. W., Leevy, C. M., & Davidson, C. S. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104072 · Cited by 978
CAESAR, J., Shaldon, S., Chiandussi, L., Guevara, L., & Sherlock, S. (1961) · PubMed · Cited by 761
THE ESTIMATION OF HEPATIC BLOOD FLOW IN MAN
Bradley, S. E., Ingelfinger, F. J., Bradley, G. P., & Curry, J. J. (1945) · Journal of Clinical Investigation · doi:10.1172/jci101676 · Cited by 712
Cardiac output and regional blood flow
Wade, B. O. L. (1963) · American Heart Journal · doi:10.1016/0002-8703(63)90141-8 · Cited by 355
Liver Circulation and Function
Bräuer, R. W. (1963) · Physiological Reviews · doi:10.1152/physrev.1963.43.1.115 · Cited by 303
The effect of exercise on the splanchnic blood flow and splanchnic blood volume in normal man.
Bradley, S. E., CHILDS, A. W., COMBES, B., Cournand, A., WADE, O. L., & WHEELER, H. O. (1956) · PubMed · Cited by 173
Limitations to prediction of maximal oxygen intake
Rowell, L. B., TAYLOR, H. L., & Wang, Y. (1964) · Journal of Applied Physiology · doi:10.1152/jappl.1964.19.5.919 · Cited by 157
Self-citationBock, A. V., Vancaulaert, C., Dill, D. B., Fölling, A., & Hurxthal, L. M. (1928) · The Journal of Physiology · doi:10.1113/jphysiol.1928.sp002514 · Cited by 157
HOLMGREN, A. (1956) · PubMed · Cited by 150
Research works printed but not linked: 9
- Krogh, A. The regulation of the supply of blood to the right heart. Skand. Arch. Physiol. 1912, 27, 227.
- Bock, A. V., C. Vancaulaert, D. B. Dill, A. F6lling, and L. M. Hurxthal. Studies in muscular ac- tivity. III. Dynamical changes occurring in man at work. J. Physiol. (Lond.) 1928, 66, 136.
- Bradley, S. E. Hepatic blood flow. Effect of pos- ture and exercise upon blood flow through the liver in Transactions of the Seventh Conference on Liver Injury. New York, Josiah Macy, Jr., Foun- dation, 1948, p. 53.
- Bruce, R. A., J. R. Blackmon, J. W. Jones, and G. Strait. Exercise testing in adult normal sub- jects and cardiac patients. Pediatrics supply.) 1963, 32, 742.
- Gregersen, M. I. Blood volume, hemorrhage, and shock in Medical Physiology, 11th ed., P. Bard, Ed. St. Louis, C. V. Mosby, 1961, p. 280.
- Bradley, S. E. Liver function as studied by hepatic vein catheterization in Transactions of the Fifth Conference on Liver Injury. New York, Josiah Macy, Jr., Foundation, 1946, p. 38.
- Cassels, D. E., and M. Morse. Blood volume anl ex- ercise. J. Pediat. 1942, 20, 352.
- Knisely, M. H., F. Harding, and H. Debacker. He- patic sphincters, brief summary of present-day knowledge. Science 1957, 125, 1023.
- Wang, Y., J. T. Shepherd, R. J. Marshall, L. Rowell, and H. L. Taylor. Cardiac response to exercise in unconditioned young men and in athletes (abstract). Circulation 1961, 24, 1064.
Cited by
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Joyner, M. J., & Casey, D. P. (2015) · Physiological Reviews · doi:10.1152/physrev.00035.2013 · Cited by 833
Hormonal and growth factor responses to heavy resistance exercise protocols
Kraemer, W. J., Marchitelli, L. J., Gordon, S. E., Harman, E. A., Dziados, J. E., Mello, R. P., Frykman, P., McCurry, D., & Fleck, S. J. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.69.4.1442 · Cited by 697
High-Intensity Intermittent Exercise and Fat Loss
Boutcher, S. H. (2010) · Journal of Obesity · doi:10.1155/2011/868305 · Cited by 614
Reinhart, M. B., Huntington, C. R., Blair, L. J., Heniford, B. T., & Augenstein, V. A. (2015) · Surgical Innovation · doi:10.1177/1553350615604053 · Cited by 518
Kraemer, W. J., Gordon, S., Fleck, S. J., Marchitelli, L. J., Mello, R. P., Dziados, J. E., Friedl, K. E., Harman, E. A., Maresh, C. M., & Fry, A. C. (1991) · International Journal of Sports Medicine · doi:10.1055/s-2007-1024673 · Cited by 479
Metadata
- Authors
- Rowell, L. B., Blackmon, J. R., & Bruce, R. A.
- Affiliations
- University of Washington (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1964-08-01
- Volume
- 43
- Issue
- 8
- Pages
- 1677-1690
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC441967
- OpenAlex
- W2112073163
- Cited by
- 394
- References
- 34
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 10 · 2013: 11 · 2012: 9
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Washington State University
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Keywords
- indocyanine green clearance, hepatic blood flow, physical activity, splanchnic circulation, venous return, autologous blood transfusion, upright posture, venous reservoir
- MeSH terms
- Blood Volume, Coloring Agents, Physical Exertion, Hemodynamics, Humans, Indocyanine Green, Liver, Liver Circulation, Liver Function Tests, Male, Metabolism, Rest, Urine
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