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Cited by 868Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressBioactive Compounds and Antitumor Agents

Oxygen metabolism and the toxic properties of phagocytes

KLEBANOFF, SEYMOUR J.·1980·Annals of Internal Medicine
DOI 10.7326/0003-4819-93-3-480
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Abstract

The products of oxygen reduction (superoxide anion, hydrogen peroxide, hydroxyl radicals) and excitation (singlet oxygen) have been implicated in the toxic properties of phagocytes (neutrophils, eosinophils, and mononuclear phagocytes). Enzymes that potentiate (such as peroxidase) or limit (such as catalase, superoxide dismutase) the toxicity of these agents contribute to the complexity of the oxygen-dependent antimicrobial systems of phagocytes. These toxic systems are dormant when the phagocyte is at rest but are activated when the need arises and directed to the destruction of invading microorganisms and other foreign cells. Occasionally, the toxic systems are directed against normal host cells and in this way contribute to the pathogenesis of disease.

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Crossref · 10.7326/0003-4819-93-3-480

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  • Thiocyanate is present at levels of 20-120 μM in serum and extracellular fluid and 800-806 mM in saliva, with the wide range attributed to smoking.

    “Thiocyanate is present at levels of 20-120 µM in serum and extracellular fluid and 800–806 mM in saliva (the wide range is attributed to smoking) [167,168].”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [168]

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Authors
KLEBANOFF, S. J.
Affiliations
Seattle. Washington
Corresponding author
KLEBANOFF, SEYMOUR J.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1980-09-01
Volume
93
Issue
3
Pages
480-489
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-93-3-480
OpenAlex
W1965340455
Cited by
868
References
86
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 7 · 2016: 8 · 2015: 17 · 2014: 12 · 2013: 11 · 2012: 16
FWCI
2.23
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords
oxygen metabolism, phagocytes, reactive oxygen species, superoxide, hydrogen peroxide, hydroxyl radicals, singlet oxygen, neutrophils, eosinophils, mononuclear phagocytes, superoxide dismutase, catalase, peroxidase, host cell damage, pathogenesis
MeSH terms
Blood Bactericidal Activity, Cytoplasmic Granules, Humans, Hydrogen Peroxide, Peroxidase, Neutrophils, Oxidation-Reduction, Oxygen, Oxygen Consumption, Peroxidases, Phagocytes, Phagocytosis, Superoxides

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