Cited by 158Systemic Lupus Erythematosus ResearchSystemic Sclerosis and Related DiseasesVasculitis and related conditions

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Antibodies to native and denatured deoxyribonucleic acid in systemic lupus erythematosus

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Arana, Roberto, Seligmann, Maxime·1967·Journal of Clinical Investigation

DOI 10.1172/jci105677PMC PMC292937

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Abstract

The relative reactivities with native and denatured DNA of 35 lupus sera were investigated by quantitative complement fixation and precipitin studies and showed great variations. The use of purified native DNA demonstrated that, in at least 22 of these 35 sera, the anti-DNA antibodies reacted with the native form, independently of denatured contaminants. Systemic lupus sera were shown to contain three main types of DNA antibodies: those reacting only with denatured DNA, those reacting to the same extent with both forms of DNA, and those reacting preferentially with native DNA. In some instances, the latter antibodies fix complement and precipitate only with native DNA but are inhibited by the denatured form. This finding points to the importance of conformation in the antigenic structure of DNA. The simultaneous occurrence of different varieties of DNA antibodies was demonstrated in several sera. Evidence was obtained that some of these human antibodies to DNA can belong to the IgM class. Thus, DNA antibodies from systemic lupus patients differ in many respects from most of the experimentally produced antibodies capable of reacting with DNA.

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Immunochemical quantitation of antigens by single radial immunodiffusion
Mancini, G., Carbonara, A. O., & Heremans, J. F. (1965) · Immunochemistry · doi:10.1016/0019-2791(65)90004-2 · Cited by 9,139
A fractionating column for analysis of nucleic acids
Mandell, J. D., & Hershey, A. D. (1960) · Analytical Biochemistry · doi:10.1016/0003-2697(60)90020-8 · Cited by 1,403
Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus.
Tan, E. M., Schur, P. H., Carr, R. I., & Kunkel, H. G. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105479 · Cited by 845
Quantitative Micro-Complement Fixation and Its Use in the Study of Antigenic Structure by Specific Antigen-Antibody Inhibition
Wasserman, E., & Levine, L. (1961) · The Journal of Immunology · doi:10.4049/jimmunol.87.3.290 · Cited by 653
Immunochemical quantitation of antigens by single radial immunodiffusion
Mancini, G. (1965) · Molecular Immunology · doi:10.1016/0161-5890(65)90004-0 · Cited by 470
ANTIBODIES SPECIFIC FOR RIBONUCLEOSIDES AND RIBONUCLEOTIDES AND THEIR REACTION WITH DNA
Erlanger, B. F., & Beiser, S. M. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.52.1.68 · Cited by 447
Complement fixation with cell nuclei and DNA in lupus erythematosus
Robbins, W. C., Holman, H. R., Deicher, H., & Kunkel, H. G. (1957) · Experimental Biology and Medicine · doi:10.3181/00379727-96-23545 · Cited by 302
A DNA-Reacting Factor in Serum of a Patient with Lupus Erythematosus Diffusus.
Ceppellini, R., Polli, E., & Celada, F. (1957) · Experimental Biology and Medicine · doi:10.3181/00379727-96-23544 · Cited by 249
PRODUCTION OF ANTIBODIES TO DENATURED DEOXYRIBONUCLEIC ACID (DNA)
Plescia, O. J., Braun, W. H., & Palczuk, N. C. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.52.2.279 · Cited by 247
The Nature of an Antigenic Determinant
Kabat, E. A. (1966) · The Journal of Immunology · doi:10.4049/jimmunol.97.1.1 · Cited by 218

Show all 42 references

Research works printed but not linked: 2

Butler, V. P., S. M. Beiser, B. F. Erlanger, S. W. Tanenbaum, S. Cohen, and A. Bendich. 1962. Pu- rine-specific antibodies which react with deoxyri- bonucleic acid (DNA). Proc. NatI. Acad. Sci. 48: 1597.
Tanenbaum, S. W., and S. M. Beiser. 1963. Py- rimidine-specific antibodies which react with de- oxyribonucleic acid (DNA). Proc. NatI. Acad. Sci. 49: 662.

Items 101–155 of 155

Micro-hemagglutination tests for detection of native and single-strand DNA antibodies and circulating DNA antigen
Inami, Y. H., Nakamura, R. M., & Tan, E. M. (1973) · Journal of Immunological Methods · doi:10.1016/0022-1759(73)90024-0 · Cited by 10
Immunosuppression — Agents, Procedures, Speculations and Prognosis
Camiener, G. W., & Wechter, W. J. (1972) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7081-8_2 · Cited by 11
Antipolynucleotide antibodies: The rheumatic connection
Koffler, D., Miller, T. E., & Faiferman, I. (1983) · Human Pathology · doi:10.1016/s0046-8177(83)80285-8 · Cited by 9
Anti-sDNA antibody purified from sera of human patients with systemic lupus erythematosus—II
Manak, R. C., & Voss, E. W. (1978) · Immunochemistry · doi:10.1016/0161-5890(78)90039-1 · Cited by 9
ANTI‐DNA ANTIBODIES: THE CHOICE OF ASSAYS FOR ROUTINE DIAGNOSTIC WORK
Sarvas, H. O., Gripenberg, M., & Leirisalo‐Repo, M. (1985) · Acta Pathologica Microbiologica Scandinavica Section C Immunology · doi:10.1111/j.1699-0463.1985.tb02915.x · Cited by 9
Evidence for infectious etiologies in connective tissue disorders
Nardo, J. M., & Norton, W. L. (1971) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(71)90002-3 · Cited by 9
The fine specificity of IgG antiguanosine antibodies in systemic lupus erythematosus
Yee, W. S., & Weisbart, R. H. (1985) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(85)90117-5 · Cited by 8
Serum and cerebrospinal fluid antibodies to single-stranded and double-stranded nucleic acids in neurological diseases
Allinquant, B., Giraud, V., Piciotti, M., & Schuller, E. (1982) · Journal of Neuroimmunology · doi:10.1016/0165-5728(82)90042-x · Cited by 8
Antibodies to Nuclear and Other Intracellular Antigens in the Connective Tissue Diseases
Alarcón-Segovia, D. (1983) · Clinics in Rheumatic Diseases · doi:10.1016/s0307-742x(21)00450-1 · Cited by 7
Clinico‐Laboratory Aspects of Anti‐Nuclear and Anti‐Native DIMA Antibody Tests
Webb, J. B. (1978) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1978.tb04787.x · Cited by 7
Nephritis in systemic lupus erythematosus
Pollak, V. E., & Kant, K. S. (1981) · La Ricerca in Clinica e in Laboratorio · doi:10.1007/bf02886682 · Cited by 7
Mechanisms of Antinuclear Antibody Production in the Rheumatic Diseases
Pisetsky, D. S. (1987) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(21)00934-0 · Cited by 6
Immune Deposit Diseases Or Of Mink and Mice.
Williams, R. C. (1968) · Arthritis & Rheumatism · doi:10.1002/art.1780110409 · Cited by 6
Antibodies to nucleic acids in systemic lupus erythematosus and rheumatoid arthritis patients and their relatives
Adamashvili, I. M., Makarova, O. V., Kvachadze, I. M., Трубников, В. И., & Zamchuk, L. A. (1983) · Immunology Letters · doi:10.1016/0165-2478(83)90027-5 · Cited by 6
Corticosteroid Therapy of the Collagen Vascular Disorders
Yount, W. J., Utsinger, P. D., Puritz, E. M., & Ortbals, D. W. (1973) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)32234-9 · Cited by 6
Anti-Nucleic Acid Antibodies in SLE—Clinical and Pathological Significance
Hughes, G. R. V. (1975) · Clinics in Rheumatic Diseases · doi:10.1016/s0307-742x(21)00142-9 · Cited by 6
Antinuclear Antibodies
Lorincz, L. L., Soltani, K., & Bernstein, J. E. (1981) · International Journal of Dermatology · doi:10.1111/j.1365-4362.1981.tb02003.x · Cited by 6
The metabolism of nucleic acids in mice.
Chia, D., Dorsch, C. A., Levy, L., & Barnett, E. V. (1979) · PubMed · Cited by 5
Temporary breakdown of immunological tolerance to dsDNA and nucleohistone antigens in rabbits infected with rinderpest virus
Imaoka, K., KANAI, Y., Yoshikawa, Y., & Yamanouchi, K. (1990) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1990.tb05483.x · Cited by 5
Monoclonal Autoantibody Directed Toward Histone and Capable of Inducing LE Cell Formation
Miller, M. M., Goto, R. M., Phillips, M. L., Klotz, J. L., Clark, S. D., & Teplitz, R. L. (1983) · Hybridoma · doi:10.1089/hyb.1983.2.201 · Cited by 5
Equilibrium theory for the binding of bivalent antibodies to regularly spaced sites on a DNA molecule
Wiegel, F. W., & Goldstein, B. (1987) · Biopolymers · doi:10.1002/bip.360260210 · Cited by 5
Antigens and Immunogens
McDuffie, F. C. (1981) · Springer eBooks · doi:10.1007/978-1-4615-7228-2_2 · Cited by 4
Binding of anti-DNA antibodies to oxidatively damaged DNA in spouses and relatives of patients with systemic lupus erythematosus
Blount, S., Lunec, J., Griffiths, H. R., Herbert, K. E., & Isenberg, D. A. (1994) · Immunology Letters · doi:10.1016/0165-2478(94)90123-6 · Cited by 4
The deoxyribonucleic acid (DNA) skin test in systemic lupus erythematosus.
Johansson, E., Kiistala, U., Niemi, K., Halme, H., & Lassus, A. (1975) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1975.tb06518.x · Cited by 4
Current status of laboratory tests for detection of antibody to DNA
Nakamura, R. M., & Tucker, E. S. (1981) · Clinical Immunology Newsletter · doi:10.1016/s0197-1859(81)80042-8 · Cited by 4
Operationally defined single‐ and double‐stranded DNA antigens in the Farr assay: diagnostic value
COUTURE, F., Beaulieu, A. D., Raptis, L. H., & Ménard, H. A. (1979) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1979.tb00880.x · Cited by 4
Effect of incomplete double strandedness of test DNA on DNA binding results.
Medof, M. E. (1982) · PubMed · Cited by 4
A modified technique of preparing mouse-liver nuclei for the detection of antinuclear antibodies (ANA) by immunofluorescence
Yantorno, C., Riera, C. M., Risemberg, A., & Strussberg, A. (1974) · Journal of Immunological Methods · doi:10.1016/0022-1759(74)90110-0 · Cited by 3
DNA and anti-DNA antibodies in mink with Aleutian disease
Vs, S., Nn, P., & Dv, B. (1975) · Bulletin of Experimental Biology and Medicine · doi:10.1007/bf00789279 · Cited by 3
Fluorescent nucleotides: Application in a fluorescence immune assay
Kardost, R. R. P., & Voss, E. W. (1982) · Molecular Immunology · doi:10.1016/0161-5890(82)90258-9 · Cited by 3
Localization of anti-nuclear antibodies on human metaphase chromosomes
Fritzler, M. J., Watson, J. I., & Church, R. B. (1974) · Journal of Immunological Methods · doi:10.1016/0022-1759(74)90042-8 · Cited by 3
LE CELLS IN BIOPSIES OF POSITIVE DEOXYRIBONUCLEIC ACID SKIN TESTS
Ores, R. O., & Mandel, E. H. (1971) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1971.tb14210.x · Cited by 3
Prozone-like phenomenon found in chemiluminescent enzyme immunoassay using magnetic particles for measurement of serum anti-single stranded DNA antibody titers: Definition and management
OBARA, T., Toyomaki, K., Uegaki, Y., Kikuchi, Y., Arai, J., Kuroda, K., & Suwabe, A. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.06.022 · Cited by 2
Calibration of target amounts of DNA in hybridization experiments using monoclonal anti-nucleoside antibodies
Traincard, F., Sakamoto, H., Rouyre, S., Mazié, J. C., & Guesdon, J. (1989) · Molecular and Cellular Probes · doi:10.1016/0890-8508(89)90034-0 · Cited by 2
The ultrastructural localization of antigens in ehrlich ascites tumor cells against antinuclear factors in lupus erytematosus sera by peroxidase-labelled antibody method
MACHIDA, M., & Hoshino, M. (1971) · Cellular and Molecular Life Sciences · doi:10.1007/bf02145895 · Cited by 2
Evidence for the presence of double-stranded polynucleotides in the neutrophil inclusions of circulating neutrophils and those which form in the presence of SLE sera
Hurd, E. R. (1981) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(81)90156-2 · Cited by 2
Characteristic differences in inhibitory effects of oligodeoxyribonucleotides from DNA on human systemic lupus erythematodes (SLE) sera and rabbit anti-DNA sera.
Wakizaka, A., & Okuhara, E. (1977) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.122.161 · Cited by 2
Antinuclear Antibody Subsets
Tuffanelli, D. L. (1983) · Dermatologic Clinics · doi:10.1016/s0733-8635(18)31007-6 · Cited by 2
Novel monoclonal antibodies to double stranded DNA that require Ca2+ or Mg2+ for their binding
Imaoka, K., & Kanai, Y. (1992) · Immunology Letters · doi:10.1016/0165-2478(92)90024-i · Cited by 1
Historia de los anticuerpos antinucleares
Gamarra, A. I., Méndez, P. P. H., Rojas, A. L., Rojas, C., Rondón, F., Sánchez, Á., & Suárez, J. F. R. (2002) · Cited by 1
Immunological Mechanisms in the Pathogenesis of Systemic Lupus Erythematosus
Whaley, K., & Buchanan, W. W. (1970) · Scottish Medical Journal · doi:10.1177/003693307001500706 · Cited by 1
Vergleichende Untersuchung zum Nachweis antinukleärer Faktoren
Helmke, K., Schäfer, B., & Federlin, K. (1978) · Verhandlungen der Deutschen Gesellschaft für Innere Medizin · doi:10.1007/978-3-642-85453-8_337 · Cited by 1
Zellkernantigene bei systemischen Autoimmunkrankheiten: Molekulare Charakteristika und klinische Bedeutung
Reimer, G. (1988) · Springer eBooks · doi:10.1007/978-3-642-73581-3_2 · Cited by 1
Nineteenth rheumatism review. Part‐III
(1970) · Arthritis & Rheumatism · doi:10.1002/art.1780130503 · Cited by 1
Studies on Measurement of Anti-DNA Antibodies in SLE Sera using Millipore Filter Radioimmunoassay.
Kobayashi, J. (1980) · Juntendō Igaku/Juntendo igaku · doi:10.14789/pjmj.26.170
La saga des auto-anticorps
Youinou, P. (2002) · Immuno-analyse & Biologie Spécialisée · doi:10.1016/s0923-2532(02)01171-7
Detection of anti-nuclear, anti-single stranded DNA, and antilymphocyte antibody in normal population, medical stuffs of SLE clinic and non-SLE clinic
Sarai, T., Nakamura, Z., Sakamoto, K., Miyawaki, S., & Ofuji, T. (1982) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.5.26
Clinical significance of anti-double stranded DNA antibodies and anti-single stranded DNA antibodies in autoimmune hepatitis and other chronic liver diseases.
TSUCHIYA, K. (1989) · Kanzo · doi:10.2957/kanzo.30.603
Beziehung zwischen Krankheitsverlauf und ANF-Serologie bei Patienten mit Lupus erythematodes disseminatus, rheumatoider Arthritis und Sklerodermie
Scheuermann, R. H., Helmke, K., & Federlin, K. (1979) · Verhandlungen der Deutschen Gesellschaft für Innere Medizin · doi:10.1007/978-3-642-85454-5_354
Radioimmunologische Bestimmung von Anti-DNS-Antikörpern bei Lupus Erythematodes
Heicke, B., Lemmel, E. ‐., & Botzenhardt, U. (1975) · Verhandlungen der Deutschen Gesellschaft für Innere Medizin · doi:10.1007/978-3-642-85450-7_323
Contribution to the 25 congress of the Japanese Society of Nephrology 招請講演 II： Treatment of lupus nephritis
Pollak, V. E. (1983) · 日本腎臓学会誌 · doi:10.14842/jpnjnephrol1959.25.776
Studies on immunological aberration and its pathogenetic roles in patients with systemic lupus erythematosus
Nakamura, Z. (1981) · Okayama Igakkai Zasshi (Journal of Okayama Medical Association) · doi:10.4044/joma1947.93.3-4_191
Detection of antibodies to denatured DNA by radioimmunoassay: Part I: Comparison of methods
Sarai, T. (1981) · Okayama Igakkai Zasshi (Journal of Okayama Medical Association) · doi:10.4044/joma1947.93.1-2_165
The role of nucleosome-induced neutrophil activation in systemic lupus erythematosus
Rönnefarth, V. M. (2007)
Antibodies to DNA Epiphenomena or Pathogens?
Hahn, B. H. (1985) · Springer eBooks · doi:10.1007/978-1-4613-2493-5_8

Authors: Arana, R., & Seligmann, M.
Affiliations: Université Paris Cité (FR)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1967-11-01
Volume: 46
Issue: 11
Pages: 1867-1882
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci105677
PMC: PMC292937
OpenAlex: W1968947138
Cited by: 158
References: 42
Citations by year: 2021: 1 · 2018: 3 · 2015: 1
FWCI: 6.23
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
Keywords: systemic lupus erythematosus, anti-DNA antibodies, native DNA, denatured DNA, DNA conformation, antigenic structure, IgM, complement fixation, precipitating antibodies, antibody heterogeneity
MeSH terms: Antibodies, Complement Fixation Tests, DNA, Humans, Lupus Erythematosus, Systemic

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Antibodies to native and denatured deoxyribonucleic acid in systemic lupus erythematosus

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