Cited by 158Systemic Lupus Erythematosus ResearchSystemic Sclerosis and Related DiseasesVasculitis and related conditions

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Antibodies to native and denatured deoxyribonucleic acid in systemic lupus erythematosus

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Arana, Roberto, Seligmann, Maxime·1967·Journal of Clinical Investigation

DOI 10.1172/jci105677PMC PMC292937

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Abstract

The relative reactivities with native and denatured DNA of 35 lupus sera were investigated by quantitative complement fixation and precipitin studies and showed great variations. The use of purified native DNA demonstrated that, in at least 22 of these 35 sera, the anti-DNA antibodies reacted with the native form, independently of denatured contaminants. Systemic lupus sera were shown to contain three main types of DNA antibodies: those reacting only with denatured DNA, those reacting to the same extent with both forms of DNA, and those reacting preferentially with native DNA. In some instances, the latter antibodies fix complement and precipitate only with native DNA but are inhibited by the denatured form. This finding points to the importance of conformation in the antigenic structure of DNA. The simultaneous occurrence of different varieties of DNA antibodies was demonstrated in several sera. Evidence was obtained that some of these human antibodies to DNA can belong to the IgM class. Thus, DNA antibodies from systemic lupus patients differ in many respects from most of the experimentally produced antibodies capable of reacting with DNA.

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Authors: Arana, R., & Seligmann, M.
Affiliations: Université Paris Cité (FR)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1967-11-01
Volume: 46
Issue: 11
Pages: 1867-1882
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci105677
PMC: PMC292937
OpenAlex: W1968947138
Cited by: 158
References: 42
Citations by year: 2021: 1 · 2018: 3 · 2015: 1
FWCI: 6.23
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
Keywords: systemic lupus erythematosus, anti-DNA antibodies, native DNA, denatured DNA, DNA conformation, antigenic structure, IgM, complement fixation, precipitating antibodies, antibody heterogeneity
MeSH terms: Antibodies, Complement Fixation Tests, DNA, Humans, Lupus Erythematosus, Systemic

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Antibodies to native and denatured deoxyribonucleic acid in systemic lupus erythematosus

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