The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Antibodies to native and denatured deoxyribonucleic acid in systemic lupus erythematosus
Open accessAbstract
The relative reactivities with native and denatured DNA of 35 lupus sera were investigated by quantitative complement fixation and precipitin studies and showed great variations. The use of purified native DNA demonstrated that, in at least 22 of these 35 sera, the anti-DNA antibodies reacted with the native form, independently of denatured contaminants. Systemic lupus sera were shown to contain three main types of DNA antibodies: those reacting only with denatured DNA, those reacting to the same extent with both forms of DNA, and those reacting preferentially with native DNA. In some instances, the latter antibodies fix complement and precipitate only with native DNA but are inhibited by the denatured form. This finding points to the importance of conformation in the antigenic structure of DNA. The simultaneous occurrence of different varieties of DNA antibodies was demonstrated in several sera. Evidence was obtained that some of these human antibodies to DNA can belong to the IgM class. Thus, DNA antibodies from systemic lupus patients differ in many respects from most of the experimentally produced antibodies capable of reacting with DNA.
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“Many test methods are available and anti-dsDNA tests, by design, detect different subpopulations of anti-dsDNA with distinct fine specificities (16,20,(22)(23)(24).”
From Anti-dsDNA Testing Specificity for Systemic Lupus Erythematosus: A Systematic Review. (2022) · cites this paper as [16]
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Citations
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Cited by
Autoantibodies to Nuclear Antigens (ANA): Their Immunobiology and Medicine
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Metadata
- Authors
- Arana, R., & Seligmann, M.
- Affiliations
- Université Paris Cité (FR)
- Venue
- Journal of Clinical Investigation
- Published
- 1967-11-01
- Volume
- 46
- Issue
- 11
- Pages
- 1867-1882
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC292937
- OpenAlex
- W1968947138
- Cited by
- 158
- References
- 42
- Citations by year
- 2021: 1 · 2018: 3 · 2015: 1
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
- Keywords
- systemic lupus erythematosus, anti-DNA antibodies, native DNA, denatured DNA, DNA conformation, antigenic structure, IgM, complement fixation, precipitating antibodies, antibody heterogeneity
- MeSH terms
- Antibodies, Complement Fixation Tests, DNA, Humans, Lupus Erythematosus, Systemic
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