The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.
Increased thyroxine turnover and thyroidal function after stimulation of hepatocellular binding of thyroxine by phenobarbital
Open accessAbstract
Administration of phenobarbital to rats in a dosage schedule previously demonstrated to increase hepatocellular binding of thyroxine results in increased hormonal turnover, due both to increased deiodination and to fecal disposition of thyroxine iodine. The rate of biliary excretion of thyroxine iodine is roughly proportional to the hepatic content of exchangeable thyroxine. The enhanced peripheral disposition of thyroxine appears to lead to increased thyroidal function, as measured by isotopic iodine studies, and the maintenance of a normal nonradioactive serum PBI. On the other hand, thyroidectomized animals maintained on a constant replacement dose of L-thyroxine and treated with phenobarbital exhibit a marked fall in serum PBI. These findings suggest that increased thyroxine flux in phenobarbital-treated animals is secondary to primary stimulation of hepatocellular binding. Exchangeable intracellular thyroxine may thus be an important determinant of hormone turnover and, possibly, of hormonal action.
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“The effect of phenobarbital to increase T 4 and T3 metabolism has been documented in rodents (173) and humans (174,175), but effects on thyroid function are more notable in rats (172).”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [173]
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Cites
ADAPTIVE INCREASES IN DRUG-METABOLIZING ENZYMES INDUCED BY PHENOBARBITAL AND OTHER DRUGS
Conney, A. H., Davison, C., Gastel, R., & Burns, J. J. (1960) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)25856-6 · Cited by 533
Proteins Associated with the Thyroid Hormones
ROBBINS, J. J., & Rall, J. E. (1960) · Physiological Reviews · doi:10.1152/physrev.1960.40.3.415 · Cited by 349
(1957) · PubMed · Cited by 198
Sterling, K., & CHODOS, R. B. (1956) · Journal of Clinical Investigation · doi:10.1172/jci103333 · Cited by 157
Gregerman, R. I., & Crowder, S. E. (1963) · Endocrinology · doi:10.1210/endo-72-3-382 · Cited by 97
Oppenheimer, J. H., Bernstein, G. S., & Hasen, J. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105577 · Cited by 91
Self-citationCavalieri, R. R., & SEARLE, G. L. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105409 · Cited by 87
Observations concerning the binding of thyroid hormones in sera of normal subjects of varying ages.
Braverman, L. W., Dawber, N. A., & Ingbar, S. H. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105434 · Cited by 74
Freinkel, N., Ingbar, S. H., Dowling, J. T., & Fine, B. R. (1957) · Journal of Clinical Investigation · doi:10.1172/jci103406 · Cited by 64
Surks, M. I., Beckwitt, H. J., & Chidsey, C. A. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-6-789 · Cited by 52
Self-citationHepatic Accumulation of125I-Thyroxine in the Rat: Augmentation by Phenobarbital and Chlordane
Bernstein, G. S., Artz, S. A., Hasen, J., & Oppenheimer, J. H. (1968) · Endocrinology · doi:10.1210/endo-82-2-406 · Cited by 46
Self-citationDynamic Clinical Studies with Radioisotopes
Kniseley, R. W., & Tauxe, W. N. (1965) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196505000-00034 · Cited by 37
Hasen, J., BERNSTEIN, G., VOLPERT, E. M., & Oppenheimer, J. H. (1968) · Endocrinology · doi:10.1210/endo-82-1-37 · Cited by 36
Self-citationIODINE-CONTAINING COMPOUNDS OF EXTRATHYROIDAL TISSUES*
Heninger, R. W., Larson, F. C., & Albright, E. C. (1963) · Journal of Clinical Investigation · doi:10.1172/jci104861 · Cited by 32
Serum Free Thyroxine and Thyroxine Binding Proteins in Male Adolescents
Malvaux, P., Nayer, P. D., Beckers, C., SCHRIECK, H. G. V. D., & VISSCHER, M. D. (1966) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-26-4-459 · Cited by 29
Thyroxine Turnover and Transport in Active Acromegaly
Inada, M., & Sterling, K. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-7-1019 · Cited by 27
COMPARATIVE DISTRIBUTION AND FATE OF I131-LABELED THYROXINE AND TRIIODOTHYRONINE1
VanArsdel, P. P., Hogness, J. R., Williams, R. H., & Elgee, N. J. (1954) · Endocrinology · doi:10.1210/endo-55-3-332 · Cited by 25
Factors Affecting Exchange of Thyroid Hormones Between Liver and Blood
Gorman, C. A., Flock, E. V., Owen, C. A., & PARIS, J. (1966) · Endocrinology · doi:10.1210/endo-79-2-391 · Cited by 23
LETTER TO THE EDITOR: Turnover of131I-Thyroxine in Patients Subjected to Surgical Trauma1
Bernstein, G. S., Hasen, J., & Oppenheimer, J. H. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-5-741 · Cited by 23
Self-citationTHE INFLUENCE OF PROMINAL ON THE I131 UPTAKE OF THE THYROID GLAND OF THE RAT
Schwarz, F. (1955) · European Journal of Endocrinology · doi:10.1530/acta.0.0180033 · Cited by 3
FURTHER INVESTIGATIONS ON THE EFFECT OF PROMINAL ON THYROID FUNCTION OF THE RAT
Schwarz, F., Kinderen, P. J. D., Haaften, J. L., & Koopman, L. E. (1955) · European Journal of Endocrinology · doi:10.1530/acta.0.0190411 · Cited by 3
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Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928
“The effect of phenobarbital to increase T4 and T3 metabolism has been documented in rodents (173) and humans (174,175), but effects on thyroid function are more notable in rats (172).”
Surks, M. I., & Sievert, R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199512213332507 · Cited by 349
Self-citationChronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency
Arias, I. M., Gartner, L. M., Cohen, M., Ben-Ezzer, J., & Levi, A. J. (1969) · The American Journal of Medicine · doi:10.1016/0002-9343(69)90224-1 · Cited by 338
Thyroid disrupting chemicals: mechanisms and mixtures
Crofton, K. M. (2008) · International Journal of Andrology · doi:10.1111/j.1365-2605.2007.00857.x · Cited by 256
Whysner, J. A. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(96)00067-8 · Cited by 233
Metadata
- Authors
- Oppenheimer, J. H., Bernstein, G., & Surks, M. I.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1968-06-01
- Volume
- 47
- Issue
- 6
- Pages
- 1399-1406
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC297295
- OpenAlex
- W2054942726
- Cited by
- 161
- References
- 22
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- phenobarbital, thyroxine, deiodination, biliary excretion, iodine, thyroid function, thyroidectomy, thyroxine replacement
- MeSH terms
- Animals, Bile, Blood Proteins, Chlordan, Iodine, Iodine Radioisotopes, Kidney, Liver, Male, Phenobarbital, Protein Binding, Thyroid Gland, Thyroidectomy, Thyroxine, Rats
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