Cited by 161Thyroid Disorders and TreatmentsProtein Interaction Studies and Fluorescence AnalysisGrowth Hormone and Insulin-like Growth Factors

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Increased thyroxine turnover and thyroidal function after stimulation of hepatocellular binding of thyroxine by phenobarbital

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Oppenheimer, Jack H., Bernstein, Gerald, Surks, Martin I.·1968·Journal of Clinical Investigation

DOI 10.1172/jci105831PMC PMC297295

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Abstract

Administration of phenobarbital to rats in a dosage schedule previously demonstrated to increase hepatocellular binding of thyroxine results in increased hormonal turnover, due both to increased deiodination and to fecal disposition of thyroxine iodine. The rate of biliary excretion of thyroxine iodine is roughly proportional to the hepatic content of exchangeable thyroxine. The enhanced peripheral disposition of thyroxine appears to lead to increased thyroidal function, as measured by isotopic iodine studies, and the maintenance of a normal nonradioactive serum PBI. On the other hand, thyroidectomized animals maintained on a constant replacement dose of L-thyroxine and treated with phenobarbital exhibit a marked fall in serum PBI. These findings suggest that increased thyroxine flux in phenobarbital-treated animals is secondary to primary stimulation of hepatocellular binding. Exchangeable intracellular thyroxine may thus be an important determinant of hormone turnover and, possibly, of hormonal action.

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Authors: Oppenheimer, J. H., Bernstein, G., & Surks, M. I.
Affiliations: Albert Einstein College of Medicine (US)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1968-06-01
Volume: 47
Issue: 6
Pages: 1399-1406
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci105831
PMC: PMC297295
OpenAlex: W2054942726
Cited by: 161
References: 22
Citations by year: 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 3
FWCI: 9.14
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: phenobarbital, thyroxine, deiodination, biliary excretion, iodine, thyroid function, thyroidectomy, thyroxine replacement
MeSH terms: Animals, Bile, Blood Proteins, Chlordan, Iodine, Iodine Radioisotopes, Kidney, Liver, Male, Phenobarbital, Protein Binding, Thyroid Gland, Thyroidectomy, Thyroxine, Rats

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Increased thyroxine turnover and thyroidal function after stimulation of hepatocellular binding of thyroxine by phenobarbital

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