The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.
Increased thyroxine turnover and thyroidal function after stimulation of hepatocellular binding of thyroxine by phenobarbital
Open accessAbstract
Administration of phenobarbital to rats in a dosage schedule previously demonstrated to increase hepatocellular binding of thyroxine results in increased hormonal turnover, due both to increased deiodination and to fecal disposition of thyroxine iodine. The rate of biliary excretion of thyroxine iodine is roughly proportional to the hepatic content of exchangeable thyroxine. The enhanced peripheral disposition of thyroxine appears to lead to increased thyroidal function, as measured by isotopic iodine studies, and the maintenance of a normal nonradioactive serum PBI. On the other hand, thyroidectomized animals maintained on a constant replacement dose of L-thyroxine and treated with phenobarbital exhibit a marked fall in serum PBI. These findings suggest that increased thyroxine flux in phenobarbital-treated animals is secondary to primary stimulation of hepatocellular binding. Exchangeable intracellular thyroxine may thus be an important determinant of hormone turnover and, possibly, of hormonal action.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The effect of phenobarbital to increase T 4 and T3 metabolism has been documented in rodents (173) and humans (174,175), but effects on thyroid function are more notable in rats (172).”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [173]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
ADAPTIVE INCREASES IN DRUG-METABOLIZING ENZYMES INDUCED BY PHENOBARBITAL AND OTHER DRUGS
Conney, A. H., Davison, C., Gastel, R., & Burns, J. J. (1960) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)25856-6 · Cited by 533
Proteins Associated with the Thyroid Hormones
ROBBINS, J. J., & Rall, J. E. (1960) · Physiological Reviews · doi:10.1152/physrev.1960.40.3.415 · Cited by 349
(1957) · PubMed · Cited by 198
Sterling, K., & CHODOS, R. B. (1956) · Journal of Clinical Investigation · doi:10.1172/jci103333 · Cited by 157
Gregerman, R. I., & Crowder, S. E. (1963) · Endocrinology · doi:10.1210/endo-72-3-382 · Cited by 97
Oppenheimer, J. H., Bernstein, G. S., & Hasen, J. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105577 · Cited by 91
Self-citationCavalieri, R. R., & SEARLE, G. L. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105409 · Cited by 87
Observations concerning the binding of thyroid hormones in sera of normal subjects of varying ages.
Braverman, L. W., Dawber, N. A., & Ingbar, S. H. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105434 · Cited by 74
Freinkel, N., Ingbar, S. H., Dowling, J. T., & Fine, B. R. (1957) · Journal of Clinical Investigation · doi:10.1172/jci103406 · Cited by 64
Surks, M. I., Beckwitt, H. J., & Chidsey, C. A. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-6-789 · Cited by 52
Self-citation
Cited by
Sorted by citations
Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928
“The effect of phenobarbital to increase T4 and T3 metabolism has been documented in rodents (173) and humans (174,175), but effects on thyroid function are more notable in rats (172).”
Surks, M. I., & Sievert, R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199512213332507 · Cited by 349
Self-citationChronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency
Arias, I. M., Gartner, L. M., Cohen, M., Ben-Ezzer, J., & Levi, A. J. (1969) · The American Journal of Medicine · doi:10.1016/0002-9343(69)90224-1 · Cited by 338
Thyroid disrupting chemicals: mechanisms and mixtures
Crofton, K. M. (2008) · International Journal of Andrology · doi:10.1111/j.1365-2605.2007.00857.x · Cited by 256
Whysner, J. A. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(96)00067-8 · Cited by 233
Metadata
- Authors
- Oppenheimer, J. H., Bernstein, G., & Surks, M. I.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1968-06-01
- Volume
- 47
- Issue
- 6
- Pages
- 1399-1406
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC297295
- OpenAlex
- W2054942726
- Cited by
- 161
- References
- 22
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- phenobarbital, thyroxine, deiodination, biliary excretion, iodine, thyroid function, thyroidectomy, thyroxine replacement
- MeSH terms
- Animals, Bile, Blood Proteins, Chlordan, Iodine, Iodine Radioisotopes, Kidney, Liver, Male, Phenobarbital, Protein Binding, Thyroid Gland, Thyroidectomy, Thyroxine, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
