CoChat
Sign Up
Cited by 269Pancreatic function and diabetesDiabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

Influence of endogenous insulin secretion on splanchnic glucose and amino acid metabolism in man

Open access
Felig, Philip, Wahren, John·1971·Journal of Clinical Investigation
DOI 10.1172/jci106659PMC PMC442070
Open this paper in CoChat — free accountOpen PDF

Abstract

Splanchnic exchange of glucose, 20 individual amino acids, lactate, and pyruvate was studied in normal subjects in the postabsorptive state and after stimulation of endogenous insulin secretion by infusion of glucose at two dose levels. In the basal state, mean splanchnic glucose production was 3.4 mg/kg per min. A net uptake of lactate, pyruvate, and nine amino acids was observed, with alanine accounting for half of the total splanchnic-amino acid extraction. Infusion of glucose at 25 mg/kg per min for 20 min resulted in a fivefold increase in arterial insulin levels and in reversal of splanchnic glucose balance to a net uptake. Splanchnic uptake of alanine, glycine, phenylalanine, lactate, and pyruvate fell by 30-60% due to a reduction in fractional extraction of these substrates, inasmuch as their arterial concentrations did not decline.Administration of glucose at 2 mg/kg per min for 45 min resulted in a 19 mg/100 ml increase in arterial glucose concentration and a doubling of arterial insulin levels. Despite the small increment in insulin, hepatic glucose production fell by 85%. Splanchnic exchange of amino acids, lactate, and pyruvate was unaltered. Estimated total glucose utilization during the infusion was no greater than in the basal state, indicating lack of stimulation of peripheral glucose uptake. IT IS CONCLUDED THAT: (a) inhibition of hepatic glucose production associated with glucose infusion and large increments in insulin levels occurs in the absence of a decrease in the concentration of circulating gluconeogenic substrate, suggesting an hepatic rather than peripheral effect; (b) the liver is the primary target organ whereby glucose homeostasis is achieved with small increments in insulin; (c) the relatively greater sensitivity of the liver's response to insulin as compared with an effect of insulin on the peripheral tissues, may be a consequence of the higher levels of endogenous insulin in portal as compared with peripheral blood.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1172/jci106659

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Insulin modulates hepatic glycogen degradation in canines and humans, although the sensitivity of glycogenolysis and gluconeogenesis to insulin concentration may differ substantially.

    “This is evidenced by the modulating influence of insulin on hepatic glycogen degradation in both canines [109] and humans [110], although the sensitivity of glycogenolysis and gluconeogenesis to insulin concentration may differ substantially [110].”

    From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [110]

    The Discussion reports that increased insulin secretion in humans accompanied a marked reduction in splanchnic glucose production and suggests direct hepatic inhibition of gluconeogenesis. It does not identify an effect on hepatic glycogen degradation or compare the insulin sensitivities of glycogenolysis and gluconeogenesis. The canine finding is attached to a different citation in the citing sentence. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. Cerasi, E., and R. Luft. 1970. The pathogenesis of dia- betes mellitus-a proposed concept. In Pathogenesis of Diabetes Mellitus. E. Cerasi and R. Luft, editors. John Wiley & Sons, Inc., New York. 17.
  2. Snedecor, G. W. 1955. In Statistical Methods. Iowa State College Press, Ames. 5th edition. 35.

Cited by

Sorted by citations

Related

Authors
Felig, P., & Wahren, J.
Affiliations
Harvard University (US)
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1971-08-01
Volume
50
Issue
8
Pages
1702-1711
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci106659
PMC
PMC442070
OpenAlex
W2119067427
Cited by
269
References
28
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 5
FWCI
31.26
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Medical Research Council
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
endogenous insulin secretion, amino acid metabolism, hepatic glucose production, glucose infusion, insulin, lactate, pyruvate, alanine, glucose homeostasis, postabsorptive state
MeSH terms
Insulin Secretion, Adult, Alanine, Amino Acids, Blood Glucose, Catheterization, Depression, Chemical, Fasting, Female, Gluconeogenesis, Glucose, Glycine, Hepatic Veins, Homeostasis, Humans, Injections, Intravenous, Insulin, Lactates, Liver, Male, Middle Aged, Phenylalanine, Pyruvates, Secretory Rate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review