CoChat
Sign Up
Cited by 45Diabetes Management and ResearchPancreatic function and diabetesGlycogen Storage Diseases and Myoclonus

Sympathetic control of hepatic glycogenolysis during glucopenia in man

Brodows, Robert G., Pi-Sunyer, F.Xavier, Campbell, Robert G.·1975·Metabolism
DOI 10.1016/0026-0495(75)90141-9
Open this paper in CoChat — free account

Abstract

Liver glycogen stores may be mobilized during hypoglycemia by release of adrenomedullary catecholamines, by release of norepinephrine from sympathetic nerve endings and by release of glucagon. To clarify the nature of peripheral sympathetic control of hepatic glycogenolysis during glucopenia in man, 2-deoxy-d-glucose (2 DG), a competitive inhibitor of glucose metabolism, was infused intravenously (50 mg/kg) to nine normal volunteers and four adrenalectomized patients for 20 min. In normal volunteers, the initial elevation of free fatty acids (FFA) and growth hormone (HGH) correspond with the rise in total catecholamines, with maximal levels attained at 60 min; lactate and cortisol rose at a slower rate, no change in IRI was noted. Plasma glucose levels were 148 percent of preinfusion values by 120 min and remained elevated. In adrenalectomized subjects, despite no change in plasma FFA, lactate, catecholamines and glucagon, glucose rose 20 percent by 150 min; the growth hormone and insulin responses were similar to normals; A significant increase in glucose response from 60 min onward was found in the 2 DG infusion studies when compared to cortisone administration, alone. Thus, during glucopenia, plasma glucose rose in spite of unchanged adrenomedullary catecholamine and glucagon levels. The findings indicate that the sympathetic neurotransmitter, norepinephrine, contributes to counter-regulatory events during 2 DG-induced glucopenia presumably via its release from hepatic sympathetic nerve endings,

Integrity signals

Registry

Crossref · 10.1016/0026-0495(75)90141-9

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 28 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Brodows, R. G., Pi-Sunyer, F. X., & Campbell, R. G.
Affiliations
University of Rochester Medicine (US)
ORCID
Campbell, Robert G.
Venue
Metabolism
Publisher
Elsevier BV
Published
1975-05
Volume
24
Issue
5
Pages
617-624
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(75)90141-9
OpenAlex
W2032117037
Cited by
45
References
28
Citations by year
2021: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2
FWCI
3.00
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
Keywords
hepatic glycogenolysis, glucopenia, sympathetic nervous system, norepinephrine, counterregulation, 2-deoxyglucose, adrenalectomy, catecholamines, glucagon, growth hormone, insulin, cortisol, free fatty acids, lactate, glucose metabolism
MeSH terms
Adrenal Glands, Adrenalectomy, Adult, Blood Glucose, Cushing Syndrome, Deoxyglucose, Fatty Acids, Nonesterified, Female, Humans, Hyperaldosteronism, Hypoglycemia, Liver, Liver Glycogen, Male, Middle Aged, Nerve Endings, Norepinephrine, Growth Hormone, Sympathetic Nervous System

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review