Cited by 431Muscle metabolism and nutritionCardiovascular and exercise physiologyAmino Acid Enzymes and Metabolism

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Amino acid metabolism in exercising man

Open access

Felig, Philip, Wahren, John·1971·Journal of Clinical Investigation

Open this paper in CoChat — free account Open PDF

Abstract

Arterial concentration and net exchange across the leg and splanchnic bed of 19 amino acids were determined in healthy, postabsorptive subjects in the resting state and after 10 and 40 min of exercise on a bicycle ergometer at work intensities of 400, 800, and 1200 kg-m/min. Arterio-portal venous differences were measured in five subjects undergoing elective cholecystectomy. In the resting state significant net release from the leg was noted for 13 amino acids, and significant splanchnic uptake was observed for 10 amino acids. Peripheral release and splanchnic uptake of alanine exceeded that of all other amino acids, accounting for 35-40% of total net amino acid exchange. Alanine and other amino acids were released in small amounts (relative to net splanchnic uptake) by the extrahepatic splanchnic tissues drained by the portal vein. During exercise arterial ananine rose 20-25% with mild exertion and 60-96% at the heavier work loads. Both at rest and during exercise a direct correlation was observed between arterial alanine and arterial pyruvate levels. Net amino acid release across the exercising leg was consistently observed at all levels of work intensity only for alanine. Estimated leg alanine output increased above resting levels in proportion to the work load. Splanchnic alanine uptake during exercise exceeded that of all other amino acids and increased by 15-20% during mild and moderate exercise, primarily as a consequence of augmented fractional extraction of alanine. For all other amino acids, there was no change in arterial concentration during mild exercise. At heavier work loads, increases of 8-35% were noted for isoleucine, leucine, methionine, tyrosine, and phenylalanine, which were attributable to altered splanchnic exchange rather than augmented peripheral release. The data suggest that (a) synthesis of alanine in muscle, presumably by transamination of glucose-derived pyruvate, is increased in exercise probably as a consequence of increased availability of pyruvate and amino groups; (b) circulating alanine serves an important carrier function in the transport of amino groups from peripheral muscle to the liver, particularly during exercise; (c) a glucose-alanine cycle exists whereby alanine, synthesized in muscle, is taken up by the liver and its glucose-derived carbon skeleton is reconverted to glucose.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci106771

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Statistical methods: Applied to experiments in agriculture and biology (4th ed.).
Snedecor, G. W. (1950) · Iowa State University Press eBooks · doi:10.1037/13268-000 · Cited by 1,524
SPECTROPHOTOMETRIC STUDIES
Drabkin, D. L., & Austin, J. H. (1935) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)74965-x · Cited by 1,018
THE FREE AMINO ACIDS OF HUMAN BLOOD PLASMA
Stein, W. H., & Moore, S. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71179-4 · Cited by 935
Statistical Methods: Applied to Experiments in Agriculture and Biology.
Brownlee, K. A., Snedecor, G. W., & Cochran, W. G. (1957) · Journal of the American Statistical Association · doi:10.2307/2281404 · Cited by 906
Amino acid metabolism during prolonged starvation
Felig, P., Owen, O. E., Wahren, J., & Cahill, G. F. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106017 · Cited by 729
Glucose metabolism during leg exercise in man
Wahren, J., Felig, P., Ahlborg, G., & Jorfeldt, L. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106772 · Cited by 598
Alanine: Key Role in Gluconeogenesis
Felig, P., Pozefsk, T., Marlis, E., & Cahill, G. F. (1970) · Science · doi:10.1126/science.167.3920.1003 · Cited by 596
Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels
Pozefsky, T., Felig, P., Tobin, J. D., Soeldner, J. S., & Cahill, G. F. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106193 · Cited by 437
Control of Gluconeogenesis from Amino Acids in the Perfused Rat Liver
Mallette, L. E., Exton, J. H., & Park, C. R. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63618-x · Cited by 436
The rate of gluconeogenesis from various precursors in the perfused rat liver
Ross, B. D., Hems, R., & Krebs, H. A. (1967) · Biochemical Journal · doi:10.1042/bj1020942 · Cited by 408

Flagged first, then by citations

Show all 37 references

Research works printed but not linked: 2

Bradley, S. E. 1946. Liver function as studied by hepatic vein catheterization. In Transactions of the Fifth Con- ference on Liver Injury. Josiah Macy Jr. Foundation, New York. 38.
Miller, L. L. 1962. The role of the liver and the non- hepatic tissues in the regulation of free amino acid Amino Acid Metabolism in Exercising Man 2713 levels in the blood. In Amino Acid Pools, Proceedings of the Symposium on Free Amino Acids, City of Hope Medical Center, 1961.

Sorted by citations

Items 101–200 of 431

Effect of branched‐chain amino acid and carbohydrate supplementation on the exercise‐induced change in plasma and muscle concentration of amino acids in human subjects
Blomstrand, E., Andersson, S. K., Hassmén, P., Ekblom, B. T., & Newsholme, E. A. (1995) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1995.tb09839.x · Cited by 87
Modulation of whole body protein metabolism, during and after exercise, by variation of dietary protein
Bowtell, J. L., Leese, G., Smith, K., Watt, P., Nevill, A. M., Rooyackers, O., Wagenmakers, A. J. M., & Rennie, M. J. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.5.1744 · Cited by 87
Effects of postexercise carbohydrate-protein feedings on muscle glycogen restoration
Carrithers, J. A., Williamson, D. L., Gallagher, P. M., Godard, M. P., SCHULZE, K. E., & Trappe, S. W. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.6.1976 · Cited by 84
Plasma Glucose Metabolism During Exercise in Humans
Coggan, A. R. (1991) · Sports Medicine · doi:10.2165/00007256-199111020-00003 · Cited by 122
Does Hemodialysis Increase Protein Breakdown? Dissociation between Whole-Body Amino Acid Turnover and Regional Muscle Kinetics
LIM, V. S., Ikizler, T. A., Raj, D. S., & Flanigan, M. J. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004080624 · Cited by 83
Effect of branched‐chain amino acid supplementation on the exercise‐induced change in aromatic amino acid concentration in human muscle
Blomstrand, E., & Newsholme, E. A. (1992) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1992.tb09422.x · Cited by 82
Plasma Glucagon Levels in Exercising Man
Felig, P., Wahren, J., Hendler, R., & AHLBORG, G. (1972) · New England Journal of Medicine · doi:10.1056/nejm197207272870412 · Cited by 82
Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells
Fan, Z., Turiel, G., Ardicoglu, R., Ghobrial, M., Masschelein, E., Kocijan, T., Zhang, J., Tan, G., Fitzgerald, G., Gorski, T., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.015 · Cited by 82
Protein requirements of soccer
Lemon, P. W. R. (1994) · Journal of Sports Sciences · doi:10.1080/02640414.1994.12059274 · Cited by 81
Physical activity, protein metabolism and protein requirements
Millward, D. J., Bowtell, J. L., Pacy, P. J., & Rennie, M. J. (1994) · Proceedings of The Nutrition Society · doi:10.1079/pns19940024 · Cited by 82
Glutamine and ornithine-α-ketoglutarate but not branched-chain amino acids reduce the loss of muscle glutamine after surgical trauma
Wernerman, J., Hammarkvist, F., Ali, M. R., & Vinnars, E. (1989) · Metabolism · doi:10.1016/0026-0495(89)90144-3 · Cited by 79
Is Increased Dietary Protein Necessary or Beneficial for Individuals with a Physically Active Lifestyle?
Lemon, P. W. R. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1996.tb03913.x · Cited by 79
Disruption of bcaa metabolism in mice impairs exercise metabolism and endurance
She, P., Zhou, Y., Zhang, Z., Griffin, K., Gowda, K., & Lynch, C. J. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01248.2009 · Cited by 75
Amino Acid Metabolism During Exercise and Following Endurance Training
Hood, D. A., & Terjung, R. L. (1990) · Sports Medicine · doi:10.2165/00007256-199009010-00003 · Cited by 76
Urea and Creatinine Production and Excretion in Urine during and after Prolonged Heavy Exercise
Refsum, H. E., & Strømme, S. B. (1974) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365517409082493 · Cited by 74
Replenishment and Depletion of Citric Acid Cycle Intermediates in Skeletal Muscle.
Spydevold, Ø. S., Davis, E. J., & Bremer, J. (1976) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1976.tb11101.x · Cited by 73
Carbohydrate, fat, and protein metabolism in muscle and in the whole body after mixed meal ingestion
Elia, M., Folmer, P., Schlatmann, A., Goren, A., & Austin, S. (1988) · Metabolism · doi:10.1016/0026-0495(88)90169-2 · Cited by 70
Lactate and Glycogen Metabolism in the Lizard Dipsosaurus Dorsalis following Exhaustive Exercise
Gleeson, T. T., & Dalessio, P. M. (1989) · Journal of Experimental Biology · doi:10.1242/jeb.144.1.377 · Cited by 70
Effect of infusing branched-chain amino acid during incremental exercise with reduced muscle glycogen content
Varnier, M., Sarto, P., Martines, D., Lora, L., Carmignoto, F., Leese, G. P., & Naccarato, R. (1994) · European Journal of Applied Physiology · doi:10.1007/bf00867923 · Cited by 70
Myopathy in McArdle's Syndrome
Slonim, A. E., & Goans, P. J. (1985) · New England Journal of Medicine · doi:10.1056/nejm198502073120607 · Cited by 70
A study of plasma free amino acid levels. III. Variations during growth and aging
Armstrong, M. D., & Stave, U. (1973) · Metabolism · doi:10.1016/0026-0495(73)90070-x · Cited by 69
The regulation of uptake and output of amino acids by rat tissues
Ishikawa, E. (1976) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(76)90010-8 · Cited by 69
The Use of Fuels for Muscular Work
McGilvery, R. W. (1975) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-5523-5_1 · Cited by 68
Differential effects of insulin resistance on leucine and glucose kinetics in obesity
Caballero, B. H., & Wurtman, R. J. (1991) · Metabolism · doi:10.1016/0026-0495(91)90192-y · Cited by 71
Metabolic time-course response after resistance exercise: A metabolomics approach
Berton, R., Conceição, M. S., Libardi, C. A., Canevarolo, R. R., Gáspari, A. F., Chacon-Mikahil, M. P. T., Zeri, A. C., & Cavaglieri, C. R. (2017) · Journal of Sports Sciences · doi:10.1080/02640414.2016.1218035 · Cited by 65
Importance of intrahepatic mechanisms to gluconeogenesis from alanine during exercise and recovery
Wasserman, D. H., Williams, P. E., Lacy, D. B., Green, D. R., & Cherrington, A. D. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.254.4.e518 · Cited by 65
Determinants of ureagenesis, with particular reference to renal failure
Walser, M. (1980) · Kidney International · doi:10.1038/ki.1980.84 · Cited by 64
Hormonal Control of Gluconeogenesis
Exton, J. H. (1979) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-0734-2_7 · Cited by 64
Influence of anoxia on the energy metabolism of goldfish Carassius auratus (L.)
van den Thillart, G., Kesbeke, F., & van Waarde, A. (1976) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(76)90055-4 · Cited by 64
The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism
Yiew, N. K. H., & Finck, B. N. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00074.2022 · Cited by 64
The two-way flux of cationic amino acids across the plasma membrane of mammalian cells is largely explained by a single transport system.
White, M. F., & Christensen, H. N. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33986-3 · Cited by 63
Influence of Exercise on Protein and Amino Acid Metabolism
Rennie, M. J. (1996) · Comprehensive physiology · doi:10.1002/cphy.cp120122 · Cited by 62
The Inter-Organ Flux of Substrates in Fed and Fasted Man, as Indicated by Arterio-Venous Balance Studies
Elia, M. (1991) · Nutrition Research Reviews · doi:10.1079/nrr19910005 · Cited by 62
The adaptation in musle oxidation of leucine to dietary protein and energy intake
Sketcher, R. D., Fern, E. B., & James, W. P. T. (1974) · British Journal Of Nutrition · doi:10.1079/bjn19740041 · Cited by 60
The Relationship between Metabolic State and Total CoA Content of Rat Liver and Heart
Smith, C. M., Cano, M. L., & Potyraj, J. J. (1978) · Journal of Nutrition · doi:10.1093/jn/108.5.854 · Cited by 59
Amino Acid Flux Across the Gastrointestinal Tract and Liver of Calves
Koeln, L. L., Schlagheck, T. G., & Webb, K. E. (1993) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(93)77564-5 · Cited by 57
Absorption Kinetics of Amino Acids, Peptides, and Intact Proteins
Have, G. A. M. T., ENGELEN, M. P. K. J., Luiking, Y. C., & Deutz, N. E. P. (2007) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.17.s1.s23 · Cited by 54
Effects of thyroid states on the Cori cycle, glucose-alanine cycle, and futile cycling of glucose metabolism in rats
Huang, M., & Lardy, H. A. (1981) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(81)90254-x · Cited by 52
Influence of hyperthyroidism on splanchnic exchange of glucose and gluconeogenic precursors.
Wahren, J., Wennlund, A., Nilsson, L. H., & Felig, P. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110117 · Cited by 52
Oral glucose tolerance test: Effect of different glucose loads on splanchnic carbohydrate and substrate metabolism in healthy man
Bratusch-Marrain, P. R., Waldhäusl, W. K., Gasic, S., Korn, A., & Nowotny, P. (1980) · Metabolism · doi:10.1016/0026-0495(80)90071-2 · Cited by 52
Free amino acid levels in muscle and liver of a patient with glucagonoma syndrome
Roth, E., Mühlbacher, F., Karner, J., Hamilton, G., & Funovics, M. A. (1987) · Metabolism · doi:10.1016/0026-0495(87)90055-2 · Cited by 51
Protein Metabolism and Endurance Exercise
Evans, W. J., Fisher, E. C., Hoerr, R., & Young, V. R. (1983) · The Physician and Sportsmedicine · doi:10.1080/00913847.1983.11708585 · Cited by 51
Dietary protein requirements in athletes
Lemon, P. W. R. (1997) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(97)00007-7 · Cited by 50
Hydrogen Ion Balance during Exercise
Jones, N. L. (1980) · Clinical Science · doi:10.1042/cs0590085 · Cited by 50
Transporters at the Interface between Cytosolic and Mitochondrial Amino Acid Metabolism
Hewton, K. G., Johal, A. S., & Parker, S. J. (2021) · Metabolites · doi:10.3390/metabo11020112 · Cited by 52
Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids
Martino, M. R., Gutiérrez‐Aguilar, M., Yiew, N. K. H., Lutkewitte, A. J., Singer, J., McCommis, K. S., Ferguson, D., Liss, K. H. H., Yoshino, J., Renkemeyer, M. K., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110733 · Cited by 47
Role of xanthine oxidase in delayed lipid peroxidation in rat liver induced by acute exhausting exercise
Koyama, K., Kaya, M., Ishigaki, T., Tsujita, J., Hori, S., 清野, 哲., & Kasugai, A. (1999) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/s004210050554 · Cited by 49
[U-14C]glucose, -alanine, and -leucine oxidation in rats at rest and two intensities of running
White, T. P., & Brooks, G. A. (1981) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1981.240.2.e155 · Cited by 47
Ammonia and amino acid metabolism in skeletal muscle: human, rodent and canine models
Graham, T. E., & MacLean, D. A. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199801000-00006 · Cited by 48
Pre-exercise branched-chain amino acid administration increases endurance performance in rats
Calders, P., Pannier, J. L., Matthys, D., & Lacroix, E. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199709000-00010 · Cited by 47
Interaction of gut and liver in nitrogen metabolism during exercise
Wasserman, D. H., Geer, R. J., Williams, P. E., Becker, T., Lacy, D. B., & Abumrad, N. N. (1991) · Metabolism · doi:10.1016/0026-0495(91)90115-d · Cited by 48
The effect of stress hormones on the interorgan flux of amino acids and on the concentration of free amino acids in skeletal muscle
Wernerman, J., Brandt, R., STRANDELL, T., Allgén, L., & Vinnars, E. (1985) · Clinical Nutrition · doi:10.1016/0261-5614(85)90005-6 · Cited by 48
Glucose delivery: a modulator of glucose uptake in contracting skeletal muscle.
Schultz, T. A., Lewis, S. B., Westbie, D. K., Wallin, J. D., & Gerich, J. E. (1977) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1977.233.6.e514 · Cited by 47
Effect of carbohydrate ingestion on ammonia metabolism during exercise in humans
Snow, R. J., Carey, M. F., Stathis, C. G., Febbraio, M. A., & Hargreaves, M. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.5.1576 · Cited by 47
Ammonia as an Indicator of Exercise Stress Implications of Recent Findings to Sports Medicine
Banister, E. W., Rajendra, W., & Mutch, B. J. C. (1985) · Sports Medicine · doi:10.2165/00007256-198502010-00004 · Cited by 48
Plasma amino acid patterns in hepatocellular carcinoma
Hirayama, C., Suyama, K., Horie, Y., Tanimoto, K., & Kato, S. X. (1987) · Biochemical Medicine and Metabolic Biology · doi:10.1016/0885-4505(87)90071-5 · Cited by 46
The variable hyponatremic response to hyperglycemia.
Morán, S., & Jamison, R. L. (1985) · PubMed Central · Cited by 46
Efficiency of anaerobic work
Gladden, L. B., & Welch, H. G. (1978) · Journal of Applied Physiology · doi:10.1152/jappl.1978.44.4.564 · Cited by 44
The Effects of Dietary Protein Supplementation on Acute Changes in Muscle Protein Synthesis and Longer-Term Changes in Muscle Mass, Strength, and Aerobic Capacity in Response to Concurrent Resistance and Endurance Exercise in Healthy Adults: A Systematic Review
Hartono, F. A., Martin-Arrowsmith, P. W., Peeters, W., & Churchward‐Venne, T. A. (2022) · Sports Medicine · doi:10.1007/s40279-021-01620-9 · Cited by 50
Acute cold exposure and the metabolism of blood glucose, lactate and pyruvate, and plasma amino acids in the hind leg of the fed and fasted young ox
Bell, A. W., Gardner, J. W., Manson, W., & Thompson, G. E. (1975) · British Journal Of Nutrition · doi:10.1079/bjn19750025 · Cited by 43
Resistance exercise enhances long-term mTORC1 sensitivity to leucine
D'Hulst, G., Masschelein, E., & De Bock, K. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101615 · Cited by 42
Human splanchnic metabolism during diabetic ketoacidosis
Owen, O. E., Block, B., Patel, M. S., Boden, G., McDonough, M. T., Kreulen, T. H., Shuman, C. R., & Reichard, G. (1977) · Metabolism · doi:10.1016/0026-0495(77)90105-6 · Cited by 42
Mobilisation of Structural Proteins During Exercise
Viru, A. (1987) · Sports Medicine · doi:10.2165/00007256-198704020-00003 · Cited by 43
The Metabolic Response to Moderate Exercise in Diabetic Man Receiving Intravenous and Subcutaneous Insulin
Murray, F. T., Zinman, B., McCLEAN, P. A., Denoga, A., Albisser, A. M., LEIBEL, B. S., NAKHOODA, A. F., STOKES, E. F., & Marliss, E. B. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-44-4-708 · Cited by 42
Regulation of Extramuscular Fuel Sources During Exercise
Wasserman, D. H., & Cherrington, A. D. (1996) · Comprehensive physiology · doi:10.1002/cphy.cp120123 · Cited by 41
Lkb1 suppresses amino acid-driven gluconeogenesis in the liver
Just, P., Charawi, S., Denis, R., Savall, M., Traoré, M., Foretz, M., Bastu, S., Magassa, S., Senni, N., Sohier, P., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19490-6 · Cited by 45
Uptake and turnover of L-(13N)-glutamate in the normal human heart and in patients with coronary artery disease
Wh, K., Helus, F., Ostertag, H. J., Tillmanns, H., & K�bler, W. (1982) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/bf00256466 · Cited by 41
Blood glucose turnover during high- and low-intensity exercise
Cooper, D. M., Barstow, T. J., Bergner, A. E., & Lee, W. N. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.257.3.e405 · Cited by 41
Alanine as a gluconeogenic carrier
Snell, K. (1979) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(79)90442-0 · Cited by 41
The Kallikrein-Kinin system and muscle metabolism: Biochemical aspects
Dietze, G., WICKLMAYR, M., Böttger, I. G., Schifman, R., Geiger, R. E., Fritz, H., & Mehnert, H. (1980) · Inflammation Research · doi:10.1007/bf01971435 · Cited by 41
Blood serum branched chain amino acids and tryptophan modifications in horses competing in long‐distance rides of different length
Assenza, A., Bergero, D., Tarantola, M., Piccione, G. G., & CAOLA, G. (2004) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2004.00493.x · Cited by 40
Amino Acid Metabolism in McArdle's Syndrome
Wahren, J., Felig, P., Havel, R. J., Jorfeldt, L., Pernow, B., & Saltin, B. (1973) · New England Journal of Medicine · doi:10.1056/nejm197304122881507 · Cited by 40
Changes in plasma amino acid distribution and urine amino acids excretion during prolonged heavy exercise
Refsum, H. E., GJESSING, L. R., & Strømme, S. B. (1979) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517909106125 · Cited by 40
Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: impact of a fitness and weight loss intervention
Grapov, D., Fiehn, O., Campbell, C., Chandler, C. J., Burnett, D. J., de Souza, E. C. L., Casazza, G. A., Keim, N. L., Newman, J. W. I., Hunter, G. R., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00091.2019 · Cited by 39
Carbohydrate metabolism of goldfish (Carassius auratus L.)
van den Thillart, G., & Smit, H. (1984) · Journal of Comparative Physiology B · doi:10.1007/bf02515152 · Cited by 39
The concentrations of free amino acids in human liver tissue obtained during laparoscopic surgery
Barle, H., Ahlman, B. H. J., Nyberg, B., Andersson, K., Essén, P., & Wernerman, J. (1996) · Clinical Physiology · doi:10.1111/j.1475-097x.1996.tb00570.x · Cited by 38
Effects of intravenously administered fructose and glucose on splanchnic amino acid and carbohydrate metabolism in hypertriglyceridemic men.
Wolfe, B. M. J., Ahuja, S. P., & Marliss, E. B. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108177 · Cited by 39
Effects of prolonged physical exercise and fasting upon plasma testosterone level in rats
Guezennec, C. Y., Ferré, P., Serrurier, B., Gomez-Mérino, D., & Pesquiès, P. (1982) · European Journal of Applied Physiology · doi:10.1007/bf02334064 · Cited by 38
Effects of intrabrachial arterial infusion of pyruvate on forearm tissue metabolism
Pozefsky, T., & Tancredi, R. G. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107048 · Cited by 38
Effects of crude protein intake from forage‐only diets on muscle amino acids and glycogen levels in horses in training
Essén-Gustavsson, B., Connysson, M., & Jansson, A. (2010) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.2010.00283.x · Cited by 39
Influence of ethanol on splanchnic and skeletal muscle substrate turnover during prolonged exercise in man.
JUHLIN‐DANNFELT, A., AHLBORG, G., Hagenfeldt, L., Jorfeldt, L., & Felig, P. (1977) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1977.233.3.e195 · Cited by 36
Response to 2-Deoxy-D-glucose and to Glucagon in “Ketotic Hypoglycemia” of Childhood: Evidence for Epinephrine Deficiency and Altered Alanine Availability
Sizonenko, P. C., Paunier, L., Vallotton, M. B., Cuendet, G. S., Zahnd, G. R., & Marliss, E. B. (1973) · Pediatric Research · doi:10.1203/00006450-197312000-00007 · Cited by 37
Glutamine: a necessary nutrient for the intensive care patient
Wernerman, J., & Hammarqvist, F. (1999) · International Journal of Colorectal Disease · doi:10.1007/s003840050199 · Cited by 36
Distribution of plasma amino acids in humans during submaximal prolonged exercise
POORTMANS, J. R., Siest, G., Galteau, M. M., & Houot, O. (1974) · European Journal of Applied Physiology · doi:10.1007/bf00421572 · Cited by 36
Amino acid uptake and output by the sheep hind limb
Ballard, F. J., Filsell, O. H., & Jarrett, I. G. (1976) · Metabolism · doi:10.1016/0026-0495(76)90073-1 · Cited by 36
Plasma cysteine concentrations in infants with respiratory distress
White, C. W., Stabler, S. P., Allen, R. H., Moreland, S. G., & Rosenberg, A. A. (1994) · The Journal of Pediatrics · doi:10.1016/s0022-3476(06)80182-4 · Cited by 35
Gut proteolysis contributes essential amino acids during exercise
Williams, B., Wolfe, R. R., Bracy, D. P., & Wasserman, D. H. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.1.e85 · Cited by 35
Metabolism of Amino Acids and Ammonia
Häussinger, D., & Gerok, W. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5041-5_11 · Cited by 35
Effect of chronic supplementation with branched-chain amino acids on the performance and hepatic and muscle glycogen content in trained rats
Junior, J. A. D. A., Falavigna, G., Rogero, M. M., Pires, I. S. O., Pedrosa, R. G., de Castro, I. A., Donato, J., & Tirapegui, J. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.03.045 · Cited by 33
Hepatic amino-acid metabolism in liver cirrhosis and in the long-term course after liver transplantation
Tietge, U. J. F., Bahr, M. J., Manns, M. P., Böker, K. H. W., & Boker, K. H. W. (2003) · Transplant International · doi:10.1111/j.1432-2277.2003.tb00215.x · Cited by 33
Intestinal Amino Acid Content in Critically III Patients
Ahlman, B. H. J., Ljungqvist, O. H., Persson, B., Bindslev, L., & Wernerman, J. (1995) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607195019004272 · Cited by 33
Effects of Age, Diet and Lactation on Lipogenesis in Rat Adipose, Liver and Mammary Tissues
Farid, M. D., Baldwin, R. L., Yang, Y. T., Osborne, E., & GRICHTING, G. (1978) · Journal of Nutrition · doi:10.1093/jn/108.3.514 · Cited by 33
Alanine and glutamine kinetics at rest and during exercise in humans
Williams, B. D., Chinkes, D. L., & Wolfe, R. R. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199807000-00005 · Cited by 32
Regulation of Protein Metabolism
Munro, H. N. (1974) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.1974.tb00708.x · Cited by 32
Significance of blood taurine levels in patients with first time acute ischaemic cardiac pain
Bhatnagar, S. K., Welty, J. D., & Yusuf, A. R. A. (1990) · International Journal of Cardiology · doi:10.1016/0167-5273(90)90293-e · Cited by 31
Effects of dexmedetomidine, propofol, sevoflurane and S-ketamine on the human metabolome
Nummela, A. J., Laaksonen, L., Laitio, T. T., Kallionpää, R., Långsjö, J., Scheinin, J., Vahlberg, T. J., Koskela, H. T., Aittomäki, V., Valli, K., et al. (2021) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000001591 · Cited by 31
Replenishment of Citric Acid Cycle Intermediates by the Purine Nucleotide Cycle in Rat Skeletal Muscle
Aragón, J. J., Tornheim, K., Goodman, M. N., & Lowenstein, J. M. (1981) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152818-8.50014-1 · Cited by 30
Exercise-induced changes in amino acid levels in skeletal muscle and plasma
Ishikura, K., Ra, S., & Ohmori, H. (2013) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.2.301 · Cited by 30
Ingestion of mycoprotein, pea protein, and their blend support comparable postexercise myofibrillar protein synthesis rates in resistance-trained individuals
West, S., Monteyne, A. J., Whelehan, G., van der Heijden, I., Abdelrahman, D. R., Murton, A. J., Finnigan, T. J. A., Stephens, F. B., & Wall, B. T. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00166.2023 · Cited by 33
The effects of short intensive exercise on plasma free amino acids in standardbred trotters
Hackl, S., van den HOVEN, R., Zickl, M., Spona, J., & Zentek, J. (2008) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2007.00801.x · Cited by 29

Authors: Felig, P., & Wahren, J.
Affiliations: Karolinska Institutet (SE)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1971-12-01
Volume: 50
Issue: 12
Pages: 2703-2714
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci106771
PMC: PMC292220
OpenAlex: W2042316825
Cited by: 431
References: 37
Citations by year: 2026: 3 · 2025: 2 · 2024: 10 · 2023: 5 · 2022: 9 · 2021: 10 · 2020: 13 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 2
FWCI: 9.04
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords: amino acid metabolism, physical activity, alanine, pyruvate, glucose-alanine cycle, transamination, work intensity, cholecystectomy
MeSH terms: Abdomen, Adult, Alanine, Amino Acids, Physical Exertion, Forearm, Glucose, Humans, Lactates, Leg, Liver, Male, Methods, Muscles, Oxygen Consumption, Pyruvates, Regional Blood Flow, Rest, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Amino acid metabolism in exercising man

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks